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  2. High-density genetic marker data, especially sequence data, imply an immense multiple testing burden. This can be ameliorated by filtering genetic variants, exploiting or accounting for correlations between va...

    Authors: Stefanie Friedrichs, Dörthe Malzahn, Elizabeth W. Pugh, Marcio Almeida, Xiao Qing Liu and Julia N. Bailey
    Citation: BMC Genetics 2016 17(Suppl 2):S8
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  3. Empirical studies and evolutionary theory support a role for rare variants in the etiology of complex traits. Given this motivation and increasing affordability of whole-exome and whole-genome sequencing, meth...

    Authors: Stephanie A. Santorico and Audrey E. Hendricks
    Citation: BMC Genetics 2016 17(Suppl 2):S6
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  4. We currently have the ability to quantify transcript abundance of messenger RNA (mRNA), genome-wide, using microarray technologies. Analyzing genotype, phenotype and expression data from 20 pedigrees, the memb...

    Authors: Rita M. Cantor and Heather J. Cordell
    Citation: BMC Genetics 2016 17(Suppl 2):S3
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  5. This paper summarizes the contributions from the Population-Based Association group at the Genetic Analysis Workshop 19. It provides an overview of the new statistical approaches tried out by group members in ...

    Authors: Justo Lorenzo Bermejo
    Citation: BMC Genetics 2016 17(Suppl 2):S2
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  6. In the analysis of current genomic data, application of machine learning and data mining techniques has become more attractive given the rising complexity of the projects. As part of the Genetic Analysis Works...

    Authors: Inke R. König, Jonathan Auerbach, Damian Gola, Elizabeth Held, Emily R. Holzinger, Marc-André Legault, Rui Sun, Nathan Tintle and Hsin-Chou Yang
    Citation: BMC Genetics 2016 17(Suppl 2):S1
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  7. The transformer (tra) is a sex determining switch in different orders of insects, including Diptera, as in the family Tephritidae. The lifelong autoregulatory loop of tra female-specific splicing can be reset by ...

    Authors: Kamoltip Laohakieat, Nidchaya Aketarawong, Siriwan Isasawin, Siripong Thitamadee and Sujinda Thanaphum
    Citation: BMC Genetics 2016 17:34
    Content type: Research article Published on:

  8. Genetic factors play an important role in hearing loss, contributing to approximately 60 % of cases of congenital hearing loss. Autosomal dominant deafness accounts for approximately 20 % of cases of hereditar...

    Authors: Yongyi Yuan, Xue Gao, Bangqing Huang, Jingqiao Lu, Guojian Wang, Xi Lin, Yan Qu and Pu Dai
    Citation: BMC Genetics 2016 17:33
    Content type: Research article Published on:

  9. The existence of moderate to high levels of linkage disequilibrium (LD) between genetic markers and quantitative trait loci (QTL) affecting traits of interest is fundamental for the success of genome-wide asso...

    Authors: Patrícia Biegelmeyer, Claudia C. Gulias-Gomes, Alexandre R. Caetano, Juan P. Steibel and Fernando F. Cardoso
    Citation: BMC Genetics 2016 17:32
    Content type: Research article Published on:

  10. The genetic variants identified by Genome-wide association study (GWAS) can only account for a small proportion of the total heritability for complex disease. The existence of gene-gene joint effects which con...

    Authors: Jing Xu, Zhongshang Yuan, Jiadong Ji, Xiaoshuai Zhang, Hongkai Li, Xuesen Wu, Fuzhong Xue and Yanxun Liu
    Citation: BMC Genetics 2016 17:31
    Content type: Methodology article Published on:

  12. Despite the emergence of stereotactic body radiotherapy (SBRT) for treatment of medically inoperable early-stage non-small-cell lung cancer patients, the molecular effects of focal exposure of limited lung vol...

    Authors: Bu-Yeo Kim, Hee Jin, Yoon-Jin Lee, Ga-Young Kang, Jaeho Cho and Yun-Sil Lee
    Citation: BMC Genetics 2016 17:29
    Content type: Research article Published on:

  14. Piglet birth weight variability, a trait also known as the within-litter homogeneity of birth weight, reflects the sow’s prolificacy, because it is positively genetically correlated with preweaning mortality b...

    Authors: Xuemin Wang, Xiaolei Liu, Dadong Deng, Mei Yu and Xiaoping Li
    Citation: BMC Genetics 2016 17(Suppl 1):S15
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  15. Genome variability of host genome and cancer cells play critical role in diversity of response to existing therapies and overall success in treating oncological diseases. In chronic myeloid leukemia targeted t...

    Authors: Alexander V. Lavrov, Ekaterina Y. Chelysheva, Svetlana A. Smirnikhina, Oleg A. Shukhov, Anna G. Turkina, Elmira P. Adilgereeva and Sergey I. Kutsev
    Citation: BMC Genetics 2016 17(Suppl 1):S14
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  16. The hypothalamus has an important role in the onset and maintenance of hypertension and stress responses. Rats with inherited stress-induced arterial hypertension (ISIAH), reproducing the human stress-sensitiv...

    Authors: Leonid O. Klimov, Nikita I. Ershov, Vadim M. Efimov, Arcady L. Markel and Olga E. Redina
    Citation: BMC Genetics 2016 17(Suppl 1):S13
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  17. The renal function plays a leading role in long-term control of arterial pressure. The comparative analysis of renal cortex transcriptome in ISIAH rats with inherited stress-induced arterial hypertension and n...

    Authors: Larisa A. Fedoseeva, Marina A. Ryazanova, Nikita I. Ershov, Arcady L. Markel and Olga E. Redina
    Citation: BMC Genetics 2016 17(Suppl 1):S12
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  18. Seed dormancy is an adaptive trait employed by flowering plants to avoid harsh environmental conditions for the continuity of their next generations. In cereal crops, moderate seed dormancy could help prevent ...

    Authors: Risper Auma Magwa, Hu Zhao and Yongzhong Xing
    Citation: BMC Genetics 2016 17:28
    Content type: Research article Published on:

  19. Increasing evidence suggests the involvement of epigenetic processes in the development of schizophrenia and bipolar disorder, and recent reviews have focused on findings in post-mortem brain tissue. A systema...

    Authors: Nina Teroganova, Leah Girshkin, Catherine M. Suter and Melissa J. Green
    Citation: BMC Genetics 2016 17:27
    Content type: Research article Published on:

  20. Copy number variation (CNV) is an important source of genetic variability associated with phenotypic variation and disease susceptibility. Comprehensive genome-wide CNV maps provide valuable information for ge...

    Authors: Shinji Sasaki, Toshio Watanabe, Shota Nishimura and Yoshikazu Sugimoto
    Citation: BMC Genetics 2016 17:26
    Content type: Research article Published on:

  21. The cultivated peanut (Arachis hypogaea L.) is an important oil and food crop in the world. Pod- and kernel-related traits are direct factors involved in determining the yield of the peanut. However, the genetic ...

    Authors: Weigang Chen, Yongqing Jiao, Liangqiang Cheng, Li Huang, Boshou Liao, Mei Tang, Xiaoping Ren, Xiaojing Zhou, Yuning Chen and Huifang Jiang
    Citation: BMC Genetics 2016 17:25
    Content type: Research article Published on:

  22. Groupers (Epinephelus spp.) have been widely cultivated in China and South-East Asian countries. As a novel hybrid offspring crossed between E. fuscogutatus♀ and E. lanceolatus♂, Hulong grouper exhibits significa...

    Authors: Ying Sun, Chuan-Yu Guo, Deng-Dong Wang, Xiao Feng Li, Ling Xiao, Xinhui Zhang, Xinxin You, Qiong Shi, Guo-Jun Hu, Chao Fang, Hao-Ran Lin and Yong Zhang
    Citation: BMC Genetics 2016 17:24
    Content type: Research article Published on:

  23. Studies of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are crucial to the development of therapeutics in clinical medicine. Such data provide information that may ...

    Authors: Aisha N. Iskakova, Aliya A. Romanova, Akbota M. Aitkulova, Nurgul S. Sikhayeva, Elena V. Zholdybayeva and Erlan M. Ramanculov
    Citation: BMC Genetics 2016 17:23
    Content type: Research article Published on:

  25. Metagenomics allows us to acquire the potential resources from both cultivatable and uncultivable microorganisms in the environment. Here, shotgun metagenome sequencing was used to investigate microbial commun...

    Authors: Xian Zhang, Jiaojiao Niu, Yili Liang, Xueduan Liu and Huaqun Yin
    Citation: BMC Genetics 2016 17:21
    Content type: Research article Published on:

  26. Arterial stiffness is an independent predictor of cardiovascular outcomes in hypertensive patients including myocardial infarction, fatal stroke, cerebral micro-bleeds which predicts cerebral hemorrhage in hyp...

    Authors: Julius L. Decano, Khristine A. Pasion, Nicole Black, Nicholas J. Giordano, Victoria L. Herrera and Nelson Ruiz-Opazo
    Citation: BMC Genetics 2016 17:19
    Content type: Research article Published on:

  27. Methods for parentage control in cattle have changed since their initial implementation in the late 1950’s from blood group typing to more current single nucleotide polymorphism determination. In the early 199...

    Authors: Bertram Brenig and Ekkehard Schütz
    Citation: BMC Genetics 2016 17:18
    Content type: Research article Published on:

  28. The oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences...

    Authors: Polina R. Butovskaya, Oleg E. Lazebny, Evgeniya M. Sukhodolskaya, Vasily A. Vasiliev, Daria A. Dronova, Juliya N. Fedenok, Aracelli Rosa, Elena N. Peletskaya, Alexey P. Ryskov and Marina L. Butovskaya
    Citation: BMC Genetics 2016 17:17
    Content type: Research article Published on:

  29. The serotonin 2A receptor is widely implicated in genetic association studies and remains an important drug target for psychiatric, neurological, and cardiovascular cond...

    Authors: Cara L. Ruble, Ryan M. Smith, John Calley, Leanne Munsie, David C. Airey, Yuan Gao, Joo Heon Shin, Thomas M. Hyde, Richard E. Straub, Daniel R. Weinberger and Laura K. Nisenbaum
    Citation: BMC Genetics 2016 17:16
    Content type: Research article Published on:

  30. In animal breeding, genetic variance for complex traits is often estimated using linear mixed models that incorporate information from single nucleotide polymorphism (SNP) markers using a realized genomic rela...

    Authors: Pernille Sarup, Just Jensen, Tage Ostersen, Mark Henryon and Peter Sørensen
    Citation: BMC Genetics 2016 17:11
    Content type: Research article Published on:

  31. The prevalence of Type 2 Diabetes (T2D) mellitus in the past decades, has reached epidemic proportions. Several lines of evidence support the role of genetic variation in the pathogenesis of T2D and insulin re...

    Authors: Hanifa J. Abu-Toamih Atamni, Richard Mott, Morris Soller and Fuad A. Iraqi
    Citation: BMC Genetics 2016 17:10
    Content type: Research article Published on:

  32. Microsatellites or simple sequence repeats (SSRs) are DNA sequences consisting of 1–6 bp tandem repeat motifs present in the genome. SSRs are considered to be one of the most powerful tools in genetic studies....

    Authors: Sonali Sachin Ranade, Yao-Cheng Lin, Yves Van de Peer and María Rosario García-Gil
    Citation: BMC Genetics 2015 16:149
    Content type: Research article Published on:

  34. African Americans experience disproportionately higher prevalence of type 2 diabetes and related risk factors. Little research has been done on the association of ADIPOQ gene on type 2 diabetes, plasma adiponecti...

    Authors: Sharon K. Davis, Ruihua Xu, Samson Y. Gebreab, Pia Riestra, Amadou Gaye, Rumana J. Khan, James G. Wilson and Aurelian Bidulescu
    Citation: BMC Genetics 2015 16:147
    Content type: Research article Published on:

  35. The use of information across populations is an attractive approach to increase the accuracy of genomic prediction for numerically small populations. However, accuracies of across population genomic prediction...

    Authors: S. van den Berg, M. P. L. Calus, T. H. E. Meuwissen and Y. C. J. Wientjes
    Citation: BMC Genetics 2015 16:146
    Content type: Research article Published on:

  36. In mammals, multigenerational environmental effects have been documented by either epidemiological studies in human or animal experiments in rodents. Whether such phenomena also occur in birds for more than on...

    Authors: Jean-Michel Brun, Marie-Dominique Bernadet, Alexis Cornuez, Sophie Leroux, Loys Bodin, Benjamin Basso, Stéphane Davail, Mathilde Jaglin, Michel Lessire, Xavier Martin, Nadine Sellier, Mireille Morisson and Frédérique Pitel
    Citation: BMC Genetics 2015 16:145
    Content type: Research article Published on:

  38. Etl4lacZ (Enhancer trap locus 4) and SktGt (Sickle tail) are lacZ reporter gene integrations into the same locus on mouse chromosome 2 targeting a gene that is expressed in the notochord of early embryos and in m...

    Authors: Katrin Serth, Anja Beckers, Karin Schuster-Gossler, Maria N. Pavlova, Julia Müller, Mariel C. Paul, Richard Reinhardt and Achim Gossler
    Citation: BMC Genetics 2015 16:143
    Content type: Research article Published on:

  39. Premature flowering or bolting is an undesirable characteristic that causes severe sugar yield losses and interferes with harvesting. Vernalization is a prerequisite for the floral induction, achieved by expos...

    Authors: Chiara Broccanello, Piergiorgio Stevanato, Filippo Biscarini, Dario Cantu and Massimo Saccomani
    Citation: BMC Genetics 2015 16:142
    Content type: Research article Published on:

  40. Asthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions in recent years, their mechanisms have yet to be explored. Several genome-wide association studi...

    Authors: Gustavo N. O. Costa, Frank Dudbridge, Rosemeire L. Fiaccone, Thiago M. da Silva, Jackson S. Conceição, Agostino Strina, Camila A. Figueiredo, Wagner C. S. Magalhães, Maira R. Rodrigues, Mateus H. Gouveia, Fernanda S. G. Kehdy, Andrea R. V. R. Horimoto, Bernardo Horta, Esteban G. Burchard, Maria Pino-Yanes, Blanca Del Rio Navarro…
    Citation: BMC Genetics 2015 16:141
    Content type: Research article Published on:

  41. The establishment of the bisexual fertile fish hybrid lineage including the allodiploid and allotetraploid hybrids, from interspecific hybridization of red crucian carp (Carassius auratus red var. 2n = 100, 2n = ...

    Authors: Chun Zhang, Lihai Ye, Yiyi Chen, Jun Xiao, Yanhong Wu, Min Tao, Yamei Xiao and Shaojun Liu
    Citation: BMC Genetics 2015 16:140
    Content type: Research article Published on:

  42. Adaption to cold temperatures, especially those below freezing, is essential for animal survival in cold environments. Freezing is also used for many medical, scientific, and industrial purposes. Natural freez...

    Authors: Jian-Ping Hu, Xiao-Ying Xu, Li-Ying Huang, Li-shun Wang and Ning-Yuan Fang
    Citation: BMC Genetics 2015 16:139
    Content type: Research article Published on:

  43. Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ...

    Authors: Sharon M. Lutz, Michael H. Cho, Kendra Young, Craig P. Hersh, Peter J. Castaldi, Merry-Lynn McDonald, Elizabeth Regan, Manuel Mattheisen, Dawn L. DeMeo, Margaret Parker, Marilyn Foreman, Barry J. Make, Robert L. Jensen, Richard Casaburi, David A. Lomas, Surya P. Bhatt…
    Citation: BMC Genetics 2015 16:138
    Content type: Research article Published on:

  44. Human intestinal schistosomiasis caused by Schistosoma mansoni and urinary schistosomiasis caused by Schistosoma haematobium are endemic in Ethiopia. Although schistosomes look morphologically uniform, there is v...

    Authors: Mulugeta Aemero, Jérôme Boissier, Deborah Climent, Hélène Moné, Gabriel Mouahid, Nega Berhe and Berhanu Erko
    Citation: BMC Genetics 2015 16:137
    Content type: Research article Published on:

  45. Located in the Pacific Ocean between Australia and New Zealand, the unique population isolate of Norfolk Island has been shown to exhibit increased prevalence of metabolic disorders (type-2 diabetes, cardiovas...

    Authors: M. C. Benton, R. A. Lea, D. Macartney-Coxson, C. Bellis, M. A. Carless, J. E. Curran, M. Hanna, D. Eccles, G. K. Chambers, J. Blangero and L. R. Griffiths
    Citation: BMC Genetics 2015 16:136
    Content type: Research article Published on:

  46. Identification of genetic variants that are associated with fatty acid composition in beef will enhance our understanding of host genetic influence on the trait and also allow for more effective improvement of...

    Authors: Liuhong Chen, Chinyere Ekine-Dzivenu, Michael Vinsky, John Basarab, Jennifer Aalhus, Mike E. R. Dugan, Carolyn Fitzsimmons, Paul Stothard and Changxi Li
    Citation: BMC Genetics 2015 16:135
    Content type: Research article Published on:

  47. Genetic variance that is not captured by single nucleotide polymorphisms (SNPs) is due to imperfect linkage disequilibrium (LD) between SNPs and quantitative trait loci (QTLs), and the extent of LD between SNP...

    Authors: Yoshinobu Uemoto, Shinji Sasaki, Takatoshi Kojima, Yoshikazu Sugimoto and Toshio Watanabe
    Citation: BMC Genetics 2015 16:134
    Content type: Research article Published on:

  48. Individuals with dyslipidemia often develop type 2 diabetes, and diabetic patients often have dyslipidemia. It remains to be determined whether there are genetic connections between the 2 disorders.

    Authors: Qian Wang, Andrew T. Grainger, Ani Manichaikul, Emily Farber, Suna Onengut-Gumuscu and Weibin Shi
    Citation: BMC Genetics 2015 16:133
    Content type: Research article Published on:

  49. The genetic structure of human populations is the outcome of the combined action of different processes such as demographic dynamics and natural selection. Several efforts toward the characterization of popula...

    Authors: Silvia Parolo, Antonella Lisa, Davide Gentilini, Anna Maria Di Blasio, Simona Barlera, Enrico B. Nicolis, Giorgio B. Boncoraglio, Eugenio A. Parati and Silvia Bione
    Citation: BMC Genetics 2015 16:132
    Content type: Research article Published on:

  50. Fish are remarkably diverse in repertoires of visual opsins by gene duplications. Differentiation of their spatiotemporal expression patterns and absorption spectra enables fine-tuning of feature detection in ...

    Authors: Taro Tsujimura, Ryoko Masuda, Ryuichi Ashino and Shoji Kawamura
    Citation: BMC Genetics 2015 16:130
    Content type: Research article Published on:
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