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  1. As an alternative to direct DNA sequencing of PCR products, random PCR-RFLP is an efficient technique to discriminate between species. The PCR-RFLP-method is an inexpensive tool in forensic science, even if th...

    Authors: Ina Pfeiffer, Joachim Burger and Bertram Brenig
    Citation: BMC Genetics 2004 5:30
  2. Locus heterogeneity poses a major difficulty in mapping genes that influence complex genetic traits. A widely used approach to deal with this problem involves modeling linkage data in terms of finite mixture d...

    Authors: Shili Lin and Swati Biswas
    Citation: BMC Genetics 2004 5:29
  3. Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused b...

    Authors: Virginia Kaklamani, Lisa Baddi, Diana Rosman, Junjian Liu, Nathan Ellis, Carole Oddoux, Harry Ostrer, Yu Chen, Habibul Ahsan, Kenneth Offit and Boris Pasche
    Citation: BMC Genetics 2004 5:28
  4. Recent advances in the understanding of the maternal and paternal heritage of south and southwest Asian populations have highlighted their role in the colonization of Eurasia by anatomically modern humans. Fur...

    Authors: Mait Metspalu, Toomas Kivisild, Ene Metspalu, Jüri Parik, Georgi Hudjashov, Katrin Kaldma, Piia Serk, Monika Karmin, Doron M Behar, M Thomas P Gilbert, Phillip Endicott, Sarabjit Mastana, Surinder S Papiha, Karl Skorecki, Antonio Torroni and Richard Villems
    Citation: BMC Genetics 2004 5:26
  5. A frequent observation in molecular evolution is that amino-acid substitution rates show an index of dispersion (that is, ratio of variance to mean) substantially larger than one. This observation has been ter...

    Authors: Claus O Wilke
    Citation: BMC Genetics 2004 5:25
  6. The main genomic region controlling the predisposition to type 1 diabetes is the Human Leukocyte Antigens (HLA) class II of the major histocompatibility complex. Association with different HLA types depends al...

    Authors: Mourad Aribi, Soraya Moulessehoul, Ahmed-Bakir Benabadji and Mohammed Kendoucitani
    Citation: BMC Genetics 2004 5:24
  7. A large number of microsatellites have been extensively used to comprehend the genetic diversity of different global groups. This paper entails polymorphism at 15 STR in four predominant and endogamous populat...

    Authors: Revathi Rajkumar and VK Kashyap
    Citation: BMC Genetics 2004 5:23
  8. Cystic Fibrosis is a pleiotropic disease in humans with primary morbidity and mortality associated with a lung disease phenotype. However, knockout in the mouse of cftr, the gene whose mutant alleles are responsi...

    Authors: J Craig Cohen, Lennart KA Lundblad, Jason HT Bates, Michael Levitzky and Janet E Larson
    Citation: BMC Genetics 2004 5:21
  9. Polymorphisms were investigated within the ZmPox3 maize peroxidase gene, possibly involved in lignin biosynthesis because of its colocalization with a cluster of QTL related to lignin content and cell wall digest...

    Authors: Carine Guillet-Claude, Christelle Birolleau-Touchard, Domenica Manicacci, Peter M Rogowsky, Joan Rigau, Alain Murigneux, Jean-Pierre Martinant and Yves Barrière
    Citation: BMC Genetics 2004 5:19
  10. Age-related macular degeneration (AMD) is a complex disorder that is responsible for the majority of central vision loss in older adults living in developed countries. Phenotypic and genetic heterogeneity comp...

    Authors: Silke Schmidt, William K Scott, Eric A Postel, Anita Agarwal, Elizabeth R Hauser, Monica A De La Paz, John R Gilbert, Daniel E Weeks, Michael B Gorin, Jonathan L Haines and Margaret A Pericak-Vance
    Citation: BMC Genetics 2004 5:18
  11. There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD). Most studies have included predominantly men and the asso...

    Authors: Debbie A Lawlor, Ian NM Day, Tom R Gaunt, Lesley J Hinks, Patricia J Briggs, Matthew Kiessling, Nick Timpson, George Davey Smith and Shah Ebrahim
    Citation: BMC Genetics 2004 5:17
  12. Molecular characterization of cattle breeds is important for the prevention of germplasm erosion by cross breeding. The Indian zebu cattle have their significant role in evolution of present day cattle breeds and...

    Authors: Muralidhar Metta, Sriramana Kanginakudru, Narasimharao Gudiseva and Javaregowda Nagaraju
    Citation: BMC Genetics 2004 5:16
  13. Hormones frequently guide animal development via the induction of cascades of gene activities, whose products further amplify an initial hormonal stimulus. In Drosophila the transformation of the larva into the p...

    Authors: Yuri B Schwartz, Tatiana Boykova, Elena S Belyaeva, Michael Ashburner and Igor F Zhimulev
    Citation: BMC Genetics 2004 5:15
  14. Monozygotic twin pairs who are genetically identical would be potentially useful in gene expression study for specific traits as cases and controls, because there would be much less gene expression variation w...

    Authors: Ying T Mak, Geeta Hampson, Jon N Beresford and Tim D Spector
    Citation: BMC Genetics 2004 5:14
  15. Drosophila mojavensis has been a model system for genetic studies of ecological adaptation and speciation. However, despite its use for over half a century, no linkage map has been produced for this species or it...

    Authors: Regina Staten, Sheri Dixon Schully and Mohamed AF Noor
    Citation: BMC Genetics 2004 5:12
  16. The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers.

    Authors: Ji-Rong Long, Lan-Juan Zhao, Peng-Yuan Liu, Yan Lu, Volodymyr Dvornyk, Hui Shen, Yong-Jun Liu, Yuan-Yuan Zhang, Dong-Hai Xiong, Peng Xiao and Hong-Wen Deng
    Citation: BMC Genetics 2004 5:11
  17. At the turn of the 19th century the first observations of a female-biased sex ratio in broods and populations of the head louse, Pediculus humanus capitis, had been reported. A study by Buxton in 1940 on the sex ...

    Authors: M Alejandra Perotti, Silvia S Catalá, Analía del V Ormeño, Monika Żelazowska, Szczepan M Biliński and Henk R Braig
    Citation: BMC Genetics 2004 5:10
  18. For a diploid organism such as human, the two alleles of a particular gene can be expressed at different levels due to X chromosome inactivation, gene imprinting, different local promoter activity, or mRNA sta...

    Authors: Chunming Ding, Esther Maier, Adelbert A Roscher, Andreas Braun and Charles R Cantor
    Citation: BMC Genetics 2004 5:8
  19. A major boost to the cystic fibrosis disease research was given by the generation of various mouse models using gene targeting in embryonal stem cells. Moreover, the introduction of the same mutation on differ...

    Authors: Nikoletta Charizopoulou, Silke Jansen, Martina Dorsch, Frauke Stanke, Julia R Dorin, Hans-Jürgen Hedrich and Burkhard Tümmler
    Citation: BMC Genetics 2004 5:6
  20. The incidence of Type 1 diabetes (T1DM) is increasing fast in many populations. The reasons for this are not known, although an increase in the penetrance of the diabetes-associated alleles, through changes in...

    Authors: Janne Pitkäniemi, Päivi Onkamo, Jaakko Tuomilehto and Elja Arjas
    Citation: BMC Genetics 2004 5:5
  21. Public SNP databases are frequently used to choose SNPs for candidate genes in the association and linkage studies of complex disorders. However, their utility for such studies of diseases with ethnic-dependen...

    Authors: Volodymyr Dvornyk, Ji-Rong Long, Dong-Hai Xiong, Peng-Yuan Liu, Lan-Juan Zhao, Hui Shen, Yuan-Yuan Zhang, Yong-Jun Liu, Sonia Rocha-Sanchez, Peng Xiao, Robert R Recker and Hong-Wen Deng
    Citation: BMC Genetics 2004 5:4
  22. Rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) are complex multifactorial diseases caused by environmental influences and an unknown number of predisposing genes. The present study was under...

    Authors: Bianca Miterski, Susanne Drynda, Gundula Böschow, Wolfram Klein, Joachim Oppermann, Jörn Kekow and Jörg Thomas Epplen
    Citation: BMC Genetics 2004 5:2
  23. The genus Morus, known as mulberry, is a dioecious and cross-pollinating plant that is the sole food for the domesticated silkworm, Bombyx mori. Traditional methods using morphological traits for classification a...

    Authors: Arvind K Awasthi, GM Nagaraja, GV Naik, Sriramana Kanginakudru, K Thangavelu and Javaregowda Nagaraju
    Citation: BMC Genetics 2004 5:1
  24. There is substantial evidence for a significant genetic component to the risk for alcoholism. However, susceptibility loci or genes for alcohol dependence remain largely unknown. To identify susceptibility loc...

    Authors: Jennie Z Ma, Dong Zhang, Randolph T Dupont, Michael Dockter, Robert C Elston and Ming D Li
    Citation: BMC Genetics 2003 4(Suppl 1):S104

    This article is part of a Supplement: Volume 4 Supplement 1

  25. Atherogenic dyslipidemia (AD) is a common feature in persons with premature coronary heart disease. While several linkage studies have been carried out to dissect the genetic etiology of lipid levels, few have...

    Authors: Agustin G Yip, Qianli Ma, Marsha Wilcox, Carolien I Panhuysen, John Farrell, Lindsay A Farrer and Diego F Wyszynski
    Citation: BMC Genetics 2003 4(Suppl 1):S100

    This article is part of a Supplement: Volume 4 Supplement 1

  26. Insulin resistance, obesity, dyslipidemia, and high blood pressure characterize the metabolic syndrome. In an effort to explore the utility of different multivariate methods of data reduction to better underst...

    Authors: Lisa J Martin, Kari E North, Tom Dyer, John Blangero, Anthony G Comuzzie and Jeff Williams
    Citation: BMC Genetics 2003 4(Suppl 1):S95

    This article is part of a Supplement: Volume 4 Supplement 1

  27. For analyzing longitudinal familial data we adopted a log-linear form to incorporate heterogeneity in genetic variance components over the time, and additionally a serial correlation term in the genetic effect...

    Authors: Julia MP Soler and John Blangero
    Citation: BMC Genetics 2003 4(Suppl 1):S87

    This article is part of a Supplement: Volume 4 Supplement 1

  28. A genome-wide linkage analysis was conducted on systolic blood pressure using a score statistic. The randomly selected Replicate 34 of the simulated data was used. The score statistic was applied to the sibshi...

    Authors: Kai Wang and Yingwei Peng
    Citation: BMC Genetics 2003 4(Suppl 1):S77

    This article is part of a Supplement: Volume 4 Supplement 1

  29. This Genetic Analysis Workshop 13 contribution presents a linkage analysis of hypertension in the Framingham data based on the posterior probability of linkage, or PPL. We dichotomized the phenotype, coding in...

    Authors: Mark W Logue, Rhinda J Goedken and Veronica J Vieland
    Citation: BMC Genetics 2003 4(Suppl 1):S75

    This article is part of a Supplement: Volume 4 Supplement 1

  30. Our Markov chain Monte Carlo (MCMC) methods were used in linkage analyses of the Framingham Heart Study data using all available pedigrees. Our goal was to detect and map loci associated with covariate-adjuste...

    Authors: Andrew W George, Saonli Basu, Na Li, Joseph H Rothstein, Solveig K Sieberts, William Stewart, Ellen M Wijsman and Elizabeth A Thompson
    Citation: BMC Genetics 2003 4(Suppl 1):S71

    This article is part of a Supplement: Volume 4 Supplement 1

  31. In the analysis of complex traits such as fasting plasma glucose levels, researchers often adjust the trait for some important covariates before assessing gene susceptibility, and may at times encounter confou...

    Authors: Chien-Hsiun Chen, Chee Jen Chang, Wei-Shiung Yang, Chun-Liang Chen and Cathy SJ Fann
    Citation: BMC Genetics 2003 4(Suppl 1):S65

    This article is part of a Supplement: Volume 4 Supplement 1

  32. We report tree-based association analysis as applied to the two Framingham cohorts and to the first replication of the simulated data obtained from the Genetic Analysis Workshop 13. For this analysis, familial...

    Authors: Elizabeth J Atkinson and Mariza de Andrade
    Citation: BMC Genetics 2003 4(Suppl 1):S63

    This article is part of a Supplement: Volume 4 Supplement 1

  33. We performed a bivariate analysis on cholesterol and triglyceride levels on data from the Framingham Heart Study using a new score statistic developed for the detection of potential pleiotropic, or cluster, ge...

    Authors: Xuyang Zhang and Kai Wang
    Citation: BMC Genetics 2003 4(Suppl 1):S62

    This article is part of a Supplement: Volume 4 Supplement 1

  34. Methods to handle missing data have been an area of statistical research for many years. Little has been done within the context of pedigree analysis. In this paper we present two methods for imputing missing ...

    Authors: Brooke Fridley, Kari Rabe and Mariza de Andrade
    Citation: BMC Genetics 2003 4(Suppl 1):S42

    This article is part of a Supplement: Volume 4 Supplement 1

  35. Several different approaches can be used to examine generational and temporal trends in family studies. The measurement of offspring and parents can be made over a short period of time with parents and offspri...

    Authors: Rasika A Mathias, Marie-Hélène Roy-Gagnon, Cristina M Justice, George J Papanicolaou, Yu Ti Fan, Elizabeth W Pugh and Alexander F Wilson
    Citation: BMC Genetics 2003 4(Suppl 1):S36

    This article is part of a Supplement: Volume 4 Supplement 1

  36. To evaluate linkage evidence for body mass index (BMI) using both cross-sectional and longitudinal data, we performed genome-wide multipoint linkage analyses on subjects who had complete data at four selected ...

    Authors: Xiaohui Li, Dai Wang, Kai Yang, Xiuqing Guo, Ying-chao Lin, Carlos G Samayoa and Huiying Yang
    Citation: BMC Genetics 2003 4(Suppl 1):S35

    This article is part of a Supplement: Volume 4 Supplement 1

  37. The Framingham Heart Study is a very successful longitudinal research for cardiovascular diseases. The completion of a 10-cM genome scan in Framingham families provided an opportunity to evaluate linkage using...

    Authors: Dai Wang, Xiaohui Li, Ying-Chao Lin, Kai Yang, Xiuqing Guo and Huiying Yang
    Citation: BMC Genetics 2003 4(Suppl 1):S28

    This article is part of a Supplement: Volume 4 Supplement 1

  38. We compare two methods to detect genetic linkage by using serial observations of systolic blood pressure in pedigree data from the Framingham Heart Study focusing on chromosome 17. The first method is a varian...

    Authors: Mariza de Andrade and Curtis Olswold
    Citation: BMC Genetics 2003 4(Suppl 1):S17

    This article is part of a Supplement: Volume 4 Supplement 1

  39. Problem 1 of the Genetic Analysis Workshop 13(GAW13) contains longitudinal data of cardiovascular measurements from 330 pedigrees. The longitudinal data complicates the phenotype definition because multiple me...

    Authors: Susan L Slager and Stephen J Iturria
    Citation: BMC Genetics 2003 4(Suppl 1):S13

    This article is part of a Supplement: Volume 4 Supplement 1

  40. We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP...

    Authors: Martyn C Byng, Sheila A Fisher, Cathryn M Lewis and John C Whittaker
    Citation: BMC Genetics 2003 4(Suppl 1):S4

    This article is part of a Supplement: Volume 4 Supplement 1

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