Citation Impact
2.567 - 2-year Impact Factor
2.917 - 5-year Impact Factor
1.138 - Source Normalized Impact per Paper (SNIP)
1.008 - SCImago Journal Rank (SJR)
Usage
638,571 Downloads
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Volume 6 Supplement 1
Edited by Joan E Bailey-Wilson, Laura Almasy, Mariza de Andrade, Julia Bailey, Heike Bickeböller, Heather J Cordell, E Warwick Daw, Lynn Goldin, Ellen L Goode, Courtney Gray-McGuire, Wayne Hening, Gail Jarvik, Brion S Maher, Nancy Mendell, Andrew D Paterson, John Rice, Glen Satten, Brian Suarez, Veronica Vieland, Marsha Wilcox, Heping Zhang, Andreas Ziegler and Jean W MacCluer
Genetic Analysis Workshop 14: Microsatellite and single-nucleotide polymorphism. Go to conference site.
Noordwijkerhout, The Netherlands7-10 September 2004
Page 1 of 4
Citation: BMC Genetics 2005 6(Suppl 1):S1
The data provided to the Genetic Analysis Workshop 14 (GAW 14) was the result of a collaboration among several different groups, catalyzed by Elizabeth Pugh from The Center for Inherited Disease Research (CIDR...
Citation: BMC Genetics 2005 6(Suppl 1):S2
The Genetic Analysis Workshop 14 simulated dataset was designed 1) To test the ability to find genes related to a complex disease (such as alcoholism). Such a disease may be given a variety of definitions by d...
Citation: BMC Genetics 2005 6(Suppl 1):S3
We analyzed 143 pedigrees (364 nuclear families) in the Collaborative Study on the Genetics of Alcoholism (COGA) data provided to the participants in the Genetic Analysis Workshop 14 (GAW14) with the goal of c...
Citation: BMC Genetics 2005 6(Suppl 1):S4
The feasibility of effectively analyzing high-density single nucleotide polymorphism (SNP) maps in whole genome scans of complex traits is not known. The purpose of this study was to compare variance component...
Citation: BMC Genetics 2005 6(Suppl 1):S5
Dense SNP maps can be highly informative for linkage studies. But when parental genotypes are missing, multipoint linkage scores can be inflated in regions with substantial marker-marker linkage disequilibrium...
Citation: BMC Genetics 2005 6(Suppl 1):S6
We performed linkage and linkage disequilibrium (LD) mapping analyses to compare the power between microsatellite and single nucleotide polymorphism (SNP) markers. Chromosome-wide analyses were performed for a...
Citation: BMC Genetics 2005 6(Suppl 1):S7
Both theoretical and applied studies have proven that the utility of single nucleotide polymorphism (SNP) markers in linkage analysis is more powerful and cost-effective than current microsatellite marker assa...
Citation: BMC Genetics 2005 6(Suppl 1):S8
Alcoholism is a complex disease. There have been many reports on significant comorbidity between alcoholism and schizophrenia. For the genetic study of complex diseases, association analysis has been recommend...
Citation: BMC Genetics 2005 6(Suppl 1):S9
The efficacy of linkage studies using microsatellites and single-nucleotide polymorphisms (SNPs) was evaluated. Analyzed data were supplied by the Collaborative Study on the Genetics of Alcoholism (COGA). Alco...
Citation: BMC Genetics 2005 6(Suppl 1):S10
We performed multipoint linkage analysis of the electrophysiological trait ECB21 on chromosome 4 in the full pedigrees provided by the Collaborative Study on the Genetics of Alcoholism (COGA). Three Markov cha...
Citation: BMC Genetics 2005 6(Suppl 1):S11
Using the dataset provided for Genetic Analysis Workshop 14 by the Collaborative Study on the Genetics of Alcoholism, we performed genome-wide linkage analysis of age at onset of alcoholism to compare the util...
Citation: BMC Genetics 2005 6(Suppl 1):S12
We compared linkage analysis results for an alcoholism trait, ALDX1 (DSM-III-R and Feigner criteria) using a nonparametric linkage analysis method, which takes into account allele sharing among several affecte...
Citation: BMC Genetics 2005 6(Suppl 1):S13
Recent studies have suggested that a high-density single nucleotide polymorphism (SNP) marker set could provide equivalent or even superior information compared with currently used microsatellite (STR) marker ...
Citation: BMC Genetics 2005 6(Suppl 1):S14
Alcohol dependence is a serious public health problem. We studied data from families participating in the Collaborative Study on the Genetics of Alcoholism (COGA) and made available to participants in the Gene...
Citation: BMC Genetics 2005 6(Suppl 1):S15
The central issue for Genetic Analysis Workshop 14 (GAW14) is the question, which is the better strategy for linkage analysis, the use of single-nucleotide polymorphisms (SNPs) or microsatellite markers? To an...
Citation: BMC Genetics 2005 6(Suppl 1):S16
The Collaborative Study on the Genetics of Alcoholism (COGA) is a large-scale family study designed to identify genes that affect the risk for alcoholism and alcohol-related phenotypes. We performed genome-wid...
Citation: BMC Genetics 2005 6(Suppl 1):S17
The objective of this study is to evaluate the efficacy of a model-free linkage statistics for finding evidence of linkage using two different maps and to illustrate how the comparison of results from several ...
Citation: BMC Genetics 2005 6(Suppl 1):S18
Multivariate phenotypes underlie complex traits. Thus, instead of using the end-point trait, it may be statistically more powerful to use a multivariate phenotype correlated to the end-point trait for detectin...
Citation: BMC Genetics 2005 6(Suppl 1):S19
Genome-wide linkage analysis using microsatellite markers has been successful in the identification of numerous Mendelian and complex disease loci. The recent availability of high-density single-nucleotide pol...
Citation: BMC Genetics 2005 6(Suppl 1):S20
Three variants of the confidence set inference (CSI) procedure were proposed and applied to both the simulated and the Collaborative Study on the Genetics of Alcoholism (COGA) data. For each of the two applica...
Citation: BMC Genetics 2005 6(Suppl 1):S21
Study design strategies are of critical importance in the search for genes underlying complex diseases. Two important design choices in planning gene mapping studies are the analytic strategy to be used, which...
Citation: BMC Genetics 2005 6(Suppl 1):S22
The simultaneous testing of a large number of hypotheses in a genome scan, using individual thresholds for significance, inherently leads to inflated genome-wide false positive rates. There exist various appro...
Citation: BMC Genetics 2005 6(Suppl 1):S23
Using the simulated data of Problem 2 for Genetic Analysis Workshop 14 (GAW14), we investigated the ability of three bootstrap-based resampling estimators (a shrinkage, an out-of-sample, and a weighted estimat...
Citation: BMC Genetics 2005 6(Suppl 1):S24
Several simulation studies have suggested that a high-density single-nucleotide polymorphisms (SNPs) marker set may be as useful as a traditional microsatellites (MS) marker set in performing whole-genome link...
Citation: BMC Genetics 2005 6(Suppl 1):S25
Single-nucleotide polymorphisms (SNPs) are a class of attractive genetic markers for population genetic studies and for identifying genetic variations underlying complex traits. However, the usefulness and eff...
Citation: BMC Genetics 2005 6(Suppl 1):S26
Using the Genetic Analysis Workshop 14 (GAW14) simulated dataset, we compare microsatellite and single-nucleotide polymorphism (SNP) markers in terms of two measures of information content, the traditional ent...
Citation: BMC Genetics 2005 6(Suppl 1):S27
There is currently a great interest in using single-nucleotide polymorphisms (SNPs) in genetic linkage and association studies because of the abundance of SNPs as well as the availability of high-throughput ge...
Citation: BMC Genetics 2005 6(Suppl 1):S28
There is growing evidence that a map of dense single-nucleotide polymorphisms (SNPs) can outperform a map of sparse microsatellites for linkage analysis. There is also argument as to whether a clustered SNP ma...
Citation: BMC Genetics 2005 6(Suppl 1):S29
A thorough genetic mapping study was performed to identify predisposing genes for alcoholism dependence using the Collaborative Study on the Genetics of Alcoholism (COGA) data. The procedure comprised whole-ge...
Citation: BMC Genetics 2005 6(Suppl 1):S30
Complex disease mapping usually involves a combination of linkage and association techniques. Linkage analysis can scan the entire genome in a few hundred tests. Association tests may involve an even greater n...
Citation: BMC Genetics 2005 6(Suppl 1):S31
Increasingly, single-nucleotide polymorphism (SNP) markers are being used in preference to microsatellite markers. However, methods developed for microsatellites may be problematic when applied to SNP markers....
Citation: BMC Genetics 2005 6(Suppl 1):S32
Covariate-based linkage analyses using a conditional logistic model as implemented in LODPAL can increase the power to detect linkage by minimizing disease heterogeneity. However, each additional covariate ana...
Citation: BMC Genetics 2005 6(Suppl 1):S33
We used the LOKI software to generate multipoint identity-by-descent matrices for a microsatellite map (with 31 markers) and two single-nucleotide polymorphism (SNP) maps to examine information content across ...
Citation: BMC Genetics 2005 6(Suppl 1):S34
We have developed a simulation-based approach to the analysis of shared homozygous chromosomal segments and have applied it to data on allele sharing among alcoholics in a single Collaborative Study on the Gen...
Citation: BMC Genetics 2005 6(Suppl 1):S35
The basic idea of affected-sib-pair (ASP) linkage analysis is to test whether the inheritance pattern of a marker deviates from Mendelian expectation in a sample of ASPs. The test depends on an assumed Mendeli...
Citation: BMC Genetics 2005 6(Suppl 1):S36
In this paper, we applied the nonparametric linkage regression approach to the Caucasian genome scan data from the Collaborative Study on the Genetics of Alcoholism to search for regions of the genome that exh...
Citation: BMC Genetics 2005 6(Suppl 1):S37
We have developed a recursive-partitioning (RP) algorithm for identifying phenotype and covariate groupings that interact with the evidence for linkage. This data-mining approach for detecting gene × environme...
Citation: BMC Genetics 2005 6(Suppl 1):S38
The main goal of this paper is to couple the Haseman-Elston method with a simple yet effective Bayesian factor-screening approach. This approach selects markers by considering a set of multigenic models that i...
Citation: BMC Genetics 2005 6(Suppl 1):S39
The purposes of this study were 1) to examine the performance of a new multimarker regression approach for model-free linkage analysis in comparison to a conventional multipoint approach, and 2) to determine t...
Citation: BMC Genetics 2005 6(Suppl 1):S40
We combined the results of whole-genome linkage and association analyses to determine which markers were most strongly associated with Kofendrerd Personality Disorder. Using replicate 1 from the Genetic Analys...
Citation: BMC Genetics 2005 6(Suppl 1):S41
In order to detect linkage of the simulated complex disease Kofendrerd Personality Disorder across studies from multiple populations, we performed a genome scan meta-analysis (GSMA). Using the 7-cM microsatell...
Citation: BMC Genetics 2005 6(Suppl 1):S42
We present a meta-analysis procedure for genome-wide linkage studies (MAGS). The MAGS procedure combines genome-wide linkage results across studies with possibly distinct marker maps. We applied the MAGS proce...
Citation: BMC Genetics 2005 6(Suppl 1):S43
The calculation of multipoint likelihoods is computationally challenging, with the exact calculation of multipoint probabilities only possible on small pedigrees with many markers or large pedigrees with few m...
Citation: BMC Genetics 2005 6(Suppl 1):S44
We evaluate a method for the incorporation of covariates into linkage analysis using the Genetic Analysis Workshop 14 simulated data. Focusing on a randomly chosen replicate (42) we investigated the effect of ...
Citation: BMC Genetics 2005 6(Suppl 1):S45
For linkage analysis in affected sibling pairs, we propose a regression model to incorporate information from a disease-associated single-nucleotide polymorphism located under the linkage peak. This model can ...
Citation: BMC Genetics 2005 6(Suppl 1):S46
In this paper we investigate the power of finding linkage to a disease locus through analysis of the disease-related traits. We propose two family-based gene-model-free linkage statistics. Both involve conside...
Citation: BMC Genetics 2005 6(Suppl 1):S47
Many investigators of complexly inherited familial traits bypass classical segregation analysis to perform model-free genome-wide linkage scans. Because model-based or parametric linkage analysis may be the mo...
Citation: BMC Genetics 2005 6(Suppl 1):S48
The purpose of these analyses was to determine if incorporating or adjusting for covariates in genetic analyses helped or hindered in genetic analyses, specifically heritability and linkage analyses. To study ...
Citation: BMC Genetics 2005 6(Suppl 1):S49
In the Haseman-Elston approach the squared phenotypic difference is regressed on the proportion of alleles shared identical by descent (IBD) to map a quantitative trait to a genetic marker. In applications the...
Citation: BMC Genetics 2005 6(Suppl 1):S50
Citation Impact
2.567 - 2-year Impact Factor
2.917 - 5-year Impact Factor
1.138 - Source Normalized Impact per Paper (SNIP)
1.008 - SCImago Journal Rank (SJR)
Usage
638,571 Downloads
221 Altmetric Mentions
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