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  1. Substantial gene substitution effects on milk production traits have formerly been reported for alleles at the K232A and the promoter VNTR loci in the bovine acylCoA-diacylglycerol-acyltransferase 1 (DGAT1) gene ...

    Authors: Christa Kuehn, Christian Edel, Rosemarie Weikard and Georg Thaller
    Citation: BMC Genetics 2007 8:62
    Content type: Research article Published on:

  2. Use of anti-hyperlipidemic medications compromises genetic analysis because of altered lipid profiles. We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid va...

    Authors: Jun Wu, Michael A Province, Hilary Coon, Steven C Hunt, John H Eckfeldt, Donna K Arnett, Gerardo Heiss, Cora E Lewis, R Curtis Ellison, Dabeeru C Rao, Treva Rice and Aldi T Kraja
    Citation: BMC Genetics 2007 8:60
    Content type: Research article Published on:

  3. With the advent of "omics" (e.g. genomics, transcriptomics, proteomics and phenomics), studies can produce enormous amounts of data. Managing this diverse data and integrating with other biological data are ma...

    Authors: Sanjiv V Bhave, Cheryl Hornbaker, Tzu L Phang, Laura Saba, Razvan Lapadat, Katherina Kechris, Jeanette Gaydos, Daniel McGoldrick, Andrew Dolbey, Sonia Leach, Brian Soriano, Allison Ellington, Eric Ellington, Kendra Jones, Jonathan Mangion, John K Belknap…
    Citation: BMC Genetics 2007 8:59
    Content type: Database Published on:

  4. Genome-wide association studies are a promising new tool for deciphering the genetics of complex diseases. To choose the proper sample size and genotyping platform for such studies, power calculations that tak...

    Authors: Robert J Klein
    Citation: BMC Genetics 2007 8:58
    Content type: Research article Published on:

  6. In cattle, the gene coding for the melanocortin receptor 1 (MC1R) is known to be the main regulator of the switch between the two coat colour pigments: eumelanin (black pigment) and phaeomelanin (red pigment). So...

    Authors: Beatriz Gutiérrez-Gil, Pamela Wiener and John L Williams
    Citation: BMC Genetics 2007 8:56
    Content type: Research article Published on:

  7. Improving pork quality can be done by increasing intramuscular fat (IMF) content. This trait is influenced by quantitative trait loci (QTL) sought out in different pig populations. Considering the high IMF con...

    Authors: Marie-Pierre Sanchez, Nathalie Iannuccelli, Benjamin Basso, Jean-Pierre Bidanel, Yvon Billon, Gilles Gandemer, Hélène Gilbert, Catherine Larzul, Christian Legault, Juliette Riquet, Denis Milan and Pascale Le Roy
    Citation: BMC Genetics 2007 8:55
    Content type: Research article Published on:

  8. Rapid means to discover and enumerate unknown mutations in the exons of human genes on a pangenomic scale are needed to discover the genes carrying inherited risk for common diseases or the genes in which soma...

    Authors: Per O Ekstrøm, Jens Bjørheim and William G Thilly
    Citation: BMC Genetics 2007 8:54
    Content type: Methodology article Published on:

  9. Infectious Salmon Anaemia (ISA) is a viral disease affecting farmed Atlantic salmon (Salmo salar) worldwide. The identification of Quantitative Trait Loci (QTL) affecting resistance to the disease could improve o...

    Authors: Thomas Moen, Anna K Sonesson, Ben Hayes, Sigbjørn Lien, Hege Munck and Theo HE Meuwissen
    Citation: BMC Genetics 2007 8:53
    Content type: Research article Published on:

  10. The sickle (βs) mutation in the beta-globin gene (HBB) occurs on five "classical" βs haplotype backgrounds in ethnic groups of African ancestry. Strong selection in favour of the βs allele – a consequence of prot...

    Authors: Neil Hanchard, Abier Elzein, Clare Trafford, Kirk Rockett, Margaret Pinder, Muminatou Jallow, Rosalind Harding, Dominic Kwiatkowski and Colin McKenzie
    Citation: BMC Genetics 2007 8:52
    Content type: Research article Published on:

  11. Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting abil...

    Authors: Nicholas J Timpson, Jon Heron, Ian NM Day, Susan M Ring, Linda M Bartoshuk, Jeremy Horwood, Pauline Emmett and George Davey-Smith
    Citation: BMC Genetics 2007 8:51
    Content type: Research article Published on:

  16. The mesolimbic structures of the brain are important in the anticipation and perception of reward. Moreover, many drugs of addiction elicit their response in these structures. The M5 muscarinic receptor (M5R) ...

    Authors: Richard JL Anney, Mehrnoush Lotfi-Miri, Craig A Olsson, Sophie C Reid, Sheryl A Hemphill and George C Patton
    Citation: BMC Genetics 2007 8:46
    Content type: Research article Published on:

  17. The glaucomas are a common but incompletely understood group of diseases. DBA/2J mice develop a pigment liberating iris disease that ultimately causes elevated intraocular pressure (IOP) and glaucoma. We have ...

    Authors: Gareth R Howell, Richard T Libby, Jeffrey K Marchant, Lawriston A Wilson, Ioan M Cosma, Richard S Smith, Michael G Anderson and Simon WM John
    Citation: BMC Genetics 2007 8:45
    Content type: Research article Published on:

  18. Genome wide linkage scans have often been successful in the identification of genetic regions containing susceptibility genes for a disease. Meta analysis is used to synthesize information and can even deliver...

    Authors: Albert Rosenberger, Manu Sharma, Bertram Müller-Myhsok, Thomas Gasser and Heike Bickeböller
    Citation: BMC Genetics 2007 8:44
    Content type: Research article Published on:

  19. Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, includin...

    Authors: Sarah E Harris, Helen Fox, Alan F Wright, Caroline Hayward, John M Starr, Lawrence J Whalley and Ian J Deary
    Citation: BMC Genetics 2007 8:43
    Content type: Research article Published on:

  21. Copy number polymorphisms caused by genomic rearrangements like deletions, make a significant contribution to the genomic differences between two individuals and may add to disease predisposition. Therefore, g...

    Authors: Kerstin Wagner, Ewa Grzybowska, Dorota Butkiewicz, Jolanta Pamula-Pilat, Wioletta Pekala, Karolina Tecza, Kari Hemminki and Asta Försti
    Citation: BMC Genetics 2007 8:41
    Content type: Methodology article Published on:

  23. A variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development. Fifteen Skts loci for skin tumour susceptibility have been mapped so far by...

    Authors: Kyoko Fujiwara, Jun Igarashi, Natsumi Irahara, Makoto Kimura and Hiroki Nagase
    Citation: BMC Genetics 2007 8:39
    Content type: Research article Published on:

  25. The current genetic structure of Iberian populations has presumably been affected by the complex orography of its territory, the different people and civilizations that settled there, its ancient and complex h...

    Authors: Rosario Calderón, Rosa Lodeiro, Tito A Varela, José Fariña, Beatriz Ambrosio, Evelyne Guitard, Antonio González-Martín and Jean M Dugoujon
    Citation: BMC Genetics 2007 8:37
    Content type: Research article Published on:

  26. The maximum likelihood estimator of D' – a standard measure of linkage disequilibrium – is biased toward disequilibrium, and the bias is particularly evident in small samples and rare haplotypes.

    Authors: Paola Sebastiani and María M Abad-Grau
    Citation: BMC Genetics 2007 8:36
    Content type: Methodology article Published on:

  27. To test whether epithelial sodium channel (ENaC) genes' variants contribute to salt sensitive hypertension in Dahl rats, we screened ENaC α, β, and γ genes entire coding regions, intron-exon junctions, and the...

    Authors: Marlene F Shehata, Frans HH Leenen and Frédérique Tesson
    Citation: BMC Genetics 2007 8:35
    Content type: Research article Published on:

  29. The chemokine receptor CCR7 is a key organizer of the immune system. Gene targeting in mice revealed that Ccr7-deficient animals are severely impaired in the induction of central and peripheral tolerance. Due ...

    Authors: Daniel Kahlmann, Ana Clara Marques Davalos-Misslitz, Lars Ohl, Frauke Stanke, Torsten Witte and Reinhold Förster
    Citation: BMC Genetics 2007 8:33
    Content type: Research article Published on:

  30. Our group has previously identified a quantitative trait locus (QTL) affecting fat and protein percentages on bovine chromosome 6, and refined the QTL position to a 420-kb interval containing six genes. Studie...

    Authors: Hanne Gro Olsen, Heidi Nilsen, Ben Hayes, Paul R Berg, Morten Svendsen, Sigbjørn Lien and Theo Meuwissen
    Citation: BMC Genetics 2007 8:32
    Content type: Research article Published on:

  31. Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes. Functional assignments of archaeal DNA replication genes have been...

    Authors: Brian R Berquist, Priya DasSarma and Shiladitya DasSarma
    Citation: BMC Genetics 2007 8:31
    Content type: Research article Published on:

  33. The giant panda (Ailuropoda melanoleuca) is one of the most endangered animals due to habitat fragmentation and loss. Although the captive breeding program for this species is now nearly two decades old, research...

    Authors: Liang Zhu, Xiang-Dong Ruan, Yun-Fa Ge, Qiu-Hong Wan and Sheng-Guo Fang
    Citation: BMC Genetics 2007 8:29
    Content type: Research article Published on:

  34. Cell motility is an essential feature of the pathogenesis and morbidity of amoebiasis caused by Entamoeba histolytica. As motility depends on cytoskeletal organisation and regulation, a study of the molecular com...

    Authors: Mehreen Zaki, Jason King, Klaus Fütterer and Robert H Insall
    Citation: BMC Genetics 2007 8:28
    Content type: Research article Published on:

  35. The cat has one common blood group with two major serotypes, blood type A that is dominant to type B. A rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood type ...

    Authors: Barbara Bighignoli, Tirri Niini, Robert A Grahn, Niels C Pedersen, Lee V Millon, Michele Polli, Maria Longeri and Leslie A Lyons
    Citation: BMC Genetics 2007 8:27
    Content type: Research article Published on:

  36. Congenital fibrosis of the extraocular muscles types 1 and 3 (CFEOM1/CFEOM3) are autosomal dominant strabismus disorders that appear to result from maldevelopment of ocular nuclei and nerves. We previously rep...

    Authors: Wai-Man Chan, Caroline Andrews, Laryssa Dragan, Douglas Fredrick, Linlea Armstrong, Christopher Lyons, Michael T Geraghty, David G Hunter, Ahmad Yazdani, Elias I Traboulsi, Jan WR Pott, Nicholas J Gutowski, Sian Ellard, Elizabeth Young, Frank Hanisch, Feray Koc…
    Citation: BMC Genetics 2007 8:26
    Content type: Research article Published on:

  37. Multiple sclerosis (MS) is consistently associated with particular HLA-DRB1-DQB1 haplotypes. However, existing evidence suggests that variation at these loci does not entirely explain association of the HLA regio...

    Authors: Maria Giovanna Marrosu, Raffaele Murru, Gianna Costa, Maria Cristina Melis, Marcella Rolesu, Lucia Schirru, Elisabetta Solla, Stefania Cuccu, Maria Antonietta Secci, Michael B Whalen, Eleonora Cocco, Maura Pugliatti, Stefano Sotgiu, Giulio Rosati and Francesco Cucca
    Citation: BMC Genetics 2007 8:25
    Content type: Research article Published on:

  38. In an effort to locate susceptibility genes for type 1 diabetes (T1D) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined...

    Authors: Sergey Nejentsev, Luc J Smink, Deborah Smyth, Rebecca Bailey, Christopher E Lowe, Felicity Payne, Jennifer Masters, Lisa Godfrey, Alex Lam, Oliver Burren, Helen Stevens, Sarah Nutland, Neil M Walker, Anne Smith, Rebecca Twells, Bryan J Barratt…
    Citation: BMC Genetics 2007 8:24
    Content type: Research article Published on:

  40. The ability for serially homologous structures to acquire a separate identity has been primarily investigated for structures dependent on Hox gene input but is still incompletely understood in other systems. T...

    Authors: Antónia Monteiro, Bin Chen, Lauren C Scott, Lindsey Vedder, H Joop Prijs, Alan Belicha-Villanueva and Paul M Brakefield
    Citation: BMC Genetics 2007 8:22
    Content type: Research article Published on:

  41. Differentiating genetically between populations is valuable for admixture and population stratification detection and in understanding population history. This is easy to achieve for major continental populati...

    Authors: Jennifer B Listman, Robert T Malison, Atapol Sughondhabirom, Bao-Zhu Yang, Ryan L Raaum, Nuntika Thavichachart, Kittipong Sanichwankul, Henry R Kranzler, Sookjaroen Tangwonchai, Apiwat Mutirangura, Todd R Disotell and Joel Gelernter
    Citation: BMC Genetics 2007 8:21
    Content type: Research article Published on:

  43. Requirements for successful implementation of multivariate animal threshold models including phenotypic and genotypic information are not known yet. Here simulated horse data were used to investigate the prope...

    Authors: Kathrin F Stock, Ottmar Distl and Ina Hoeschele
    Citation: BMC Genetics 2007 8:19
    Content type: Research article Published on:

  44. Hexaploid wheat (Triticum aestivum L.) possesses a large genome that contains 1.6 × 1010 bp of DNA. Isolation of a large number of gene sequences from complex gene families with a high level of gene sequence iden...

    Authors: Xiu-Qiang Huang and Sylvie Cloutier
    Citation: BMC Genetics 2007 8:18
    Content type: Methodology article Published on:

  45. DGAT2 is a promising candidate gene for obesity because of its function as a key enzyme in fat metabolism and because of its localization on chromosome 11q13, a linkage region for extreme early onset obesity dete...

    Authors: Susann Friedel, Kathrin Reichwald, André Scherag, Harald Brumm, Anne-Kathrin Wermter, Hans-Rudolf Fries, Kerstin Koberwitz, Martin Wabitsch, Thomas Meitinger, Matthias Platzer, Heike Biebermann, Anke Hinney and Johannes Hebebrand
    Citation: BMC Genetics 2007 8:17
    Content type: Research article Published on:

  46. The long bone abnormality (lbab) mouse is a new autosomal recessive mutant characterized by overall smaller body size with proportionate dwarfing of all organs and shorter long bones. Previous linkage analysis ha...

    Authors: Yan Jiao, Jian Yan, Feng Jiao, HongBin Yang, Leah Rae Donahue, Xinmin Li, Bruce A Roe, John Stuart and Weikuan Gu
    Citation: BMC Genetics 2007 8:16
    Content type: Research article Published on:

  47. Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans. In ...

    Authors: Bianca Haase, Marcus G Doherr, Torsten Seuberlich, Cord Drögemüller, Gaudenz Dolf, Petra Nicken, Katrin Schiebel, Ute Ziegler, Martin H Groschup, Andreas Zurbriggen and Tosso Leeb
    Citation: BMC Genetics 2007 8:15
    Content type: Research article Published on:

  48. The definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association.

    Authors: Viviana Romero, Charles E Larsen, Jonathan S Duke-Cohan, Edward A Fox, Tatiana Romero, Olga P Clavijo, Dolores A Fici, Zaheed Husain, Ingrid Almeciga, Dennis R Alford, Zuheir L Awdeh, Joaquin Zuñiga, Lama El-Dahdah, Chester A Alper and Edmond J Yunis
    Citation: BMC Genetics 2007 8:14
    Content type: Research article Published on:

  49. Cigarette smoking and chemical occupational exposure are the main known risk factors for bladder transitional cell carcinoma (TCC). Oxidative DNA damage induced by carcinogens present in these exposures requir...

    Authors: Sei Chung Sak, Jennifer H Barrett, Alan B Paul, D Timothy Bishop and Anne E Kiltie
    Citation: BMC Genetics 2007 8:13
    Content type: Research article Published on:

  50. India has experienced several waves of migration since the Middle Paleolithic. It is believed that the initial demic movement into India was from Africa along the southern coastal route, approximately 60,000–8...

    Authors: Faisal Khan, Atul Kumar Pandey, Manorma Tripathi, Sudha Talwar, Prakash S Bisen, Minal Borkar and Suraksha Agrawal
    Citation: BMC Genetics 2007 8:12
    Content type: Research article Published on:
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