Selected Topics in “Systems Biology and Bioinformatics” - 2019: genetics

Genetics research at the "Centenary of human population genetics" conference and SBB-2019

Authors: Tatiana V. Tatarinova, Ludmila E. Tabikhanova, Gilda Eslami, Haihua Bai and Yuriy L. Orlov

Positive selection in admixed populations from Ethiopia

In the process of adaptation of humans to their environment, positive or adaptive selection has played a main role. Positive selection has, however, been under-studied in African populations, despite their div...

Authors: Sandra Walsh, Luca Pagani, Yali Xue, Hafid Laayouni, Chris Tyler-Smith and Jaume Bertranpetit

The medieval Mongolian roots of Y-chromosomal lineages from South Kazakhstan

The majority of the Kazakhs from South Kazakhstan belongs to the 12 clans of the Senior Zhuz. According to traditional genealogy, nine of these clans have a common ancestor and constitute the Uissun tribe. The...

Authors: Maxat Zhabagin, Zhaxylyk Sabitov, Pavel Tarlykov, Inkar Tazhigulova, Zukhra Junissova, Dauren Yerezhepov, Rakhmetolla Akilzhanov, Elena Zholdybayeva, Lan-Hai Wei, Ainur Akilzhanova, Oleg Balanovsky and Elena Balanovska

Analyzing a putative enhancer of optic disc morphology

Genome-wide association studies have identified the CDC7-TGFBR3 intergenic region on chromosome 1 to be strongly associated with optic disc area size. The mechanism of its function remained unclear until new data...

Authors: Vladimir Babenko, Roman Babenko and Yuri Orlov

The story of the lost twins: decoding the genetic identities of the Kumhar and Kurcha populations from the Indian subcontinent

The population structure of the Indian subcontinent is a tapestry of extraordinary diversity characterized by the amalgamation of autochthonous and immigrant ancestries and rigid enforcement of sociocultural s...

Authors: Ranajit Das, Vladimir A. Ivanisenko, Anastasia A. Anashkina and Priyanka Upadhyai

Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia

N-acetyltransferase 2 plays a crucial role in the metabolism of a wide range of xenobiotics, including many drugs, carcinogens, and other chemicals in the human environment. The article presents for the first ...

Authors: Roza Pavlovna Tiis, Ludmila Pavlovna Osipova, Daria Veniaminovna Lichman, Elena Nikolaevna Voronina and Maxim Leonidovich Filipenko

Disruptive natural selection by male reproductive potential prevents underexpression of protein-coding genes on the human Y chromosome as a self-domestication syndrome

In population ecology, the concept of reproductive potential denotes the most vital indicator of chances to produce and sustain a healthy descendant until his/her reproductive maturity under the best condition...

Authors: Mikhail Ponomarenko, Maxim Kleshchev, Petr Ponomarenko, Irina Chadaeva, Ekaterina Sharypova, Dmitry Rasskazov, Semyon Kolmykov, Irina Drachkova, Gennady Vasiliev, Natalia Gutorova, Elena Ignatieva, Ludmila Savinkova, Anton Bogomolov, Ludmila Osadchuk, Alexandr Osadchuk and Dmitry Oshchepkov

Molecular and cytological analysis of widely-used Gal4 driver lines for Drosophila neurobiology

The Drosophila central nervous system (CNS) is a convenient model system for the study of the molecular mechanisms of conserved neurobiological processes. The manipulation of gene activity in specific cell types ...

Authors: Anna A. Ogienko, Evgeniya N. Andreyeva, Evgeniya S. Omelina, Anastasiya L. Oshchepkova and Alexey V. Pindyurin

Amyloid-β peptides slightly affect lifespan or antimicrobial peptide gene expression in Drosophila melanogaster

Beta-amyloid peptide (Aβ) is the key protein in the pathogenesis of Alzheimer’s disease, the most common age-related neurodegenerative disorder in humans. Aβ peptide induced pathological phenotypes in differen...

Authors: Mikhail V. Shaposhnikov, Nadezhda V. Zemskaya, Lyubov А. Koval, Natalya R. Minnikhanova, Olga I. Kechko, Vladimir A. Mitkevich, Alexander A. Makarov and Alexey А. Moskalev

Genotypes diversity of env gene of Bovine leukemia virus in Western Siberia

This study describes the biodiversity and properties of Bovine leukemia virus in Western Siberia. This paper explores the effect of different genotypes of the env gene of the cattle leukemia virus on hematologica...

Authors: Natalia Blazhko, Sultan Vyshegurov, Alexander Donchenko, Kirill Shatokhin, Valeria Ryabinina, Kirill Plotnikov, Alevtina Khodakova and Sergey Pashkovskiy