Splawski I, Shen J, Timothy KW, Lehmann MH, Priori S, Robinson JL, et al. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation. 2000;102:1178–85.
Article
CAS
PubMed
Google Scholar
Dekker JM, Schouten EG, Klootwijk P, Pool J, Kromhout D. Association between QT interval and coronary heart disease in middle-aged and elderly men. The Zutphen study. Circulation. 1994;90:779–85.
Article
CAS
PubMed
Google Scholar
Schouten EG, Dekker JM, Meppelink P, Kok FJ, Vandenbroucke JP, Pool J. QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation. 1991;84:1516–23.
Article
CAS
PubMed
Google Scholar
Algra A, Tijssen JG, Roelandt JR, Pool J, Lubsen J. QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation. 1991;83:1888–94.
Article
CAS
PubMed
Google Scholar
Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP. hERG K(+) channels: structure, function, and clinical significance. Physiol Rev. 2012;92:1393–478.
Article
CAS
PubMed
Google Scholar
Hardy AB, Fox JEM, Giglou PR, Wijesekara N, Bhattacharjee A, Sultan S, et al. Characterization of erg K+ channels in alpha- and beta-cells of mouse and human islets. J Biol Chem. 2009;284:30441–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rogers GJ, Tolhurst G, Ramzan A, Habib AM, Parker HE, Gribble FM, et al. Electrical activity-triggered glucagon-like peptide-1 secretion from primary murine L-cells. J Physiol. 2011;589:1081–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rosati B, Marchetti P, Crociani O, Lecchi M, Lupi R, Arcangeli A, et al. Glucose- and arginine-induced insulin secretion by human pancreatic beta-cells: the role of HERG K(+) channels in firing and release. FASEB J Off Publ Fed Am Soc Exp Biol. 2000;14:2601–10.
CAS
Google Scholar
Hyltén-Cavallius L, Iepsen EW, Wewer Albrechtsen NJ, Svendstrup M, Lubberding AF, Hartmann B, et al. Patients with long QT syndrome due to impaired hERG-encoded Kv11.1 Potassium Channel have exaggerated endocrine pancreatic and incretin function associated with reactive hypoglycemia. Circulation. 2017;
Mühlbauer E, Bazwinsky I, Wolgast S, Klemenz A, Peschke E. Circadian changes of ether-a-go-go-related-gene (erg) potassium channel transcripts in the rat pancreas and beta-cell. Cell Mol Life Sci CMLS. 2007;64:768–80.
Article
PubMed
Google Scholar
Torekov SS, Iepsen E, Christiansen M, Linneberg A, Pedersen O, Holst JJ, et al. KCNQ1 long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia. Diabetes. 2014;63:1315–25.
Article
CAS
PubMed
Google Scholar
Hyltén-Cavallius L, Iepsen EW, Christiansen M, Graff C, Linneberg A, Pedersen O, et al. Glucose ingestion causes cardiac repolarization disturbances in type 1 long QT syndrome patients and healthy subjects. Heart Rhythm. 2017;
Johansen NB, Hansen A-LS, Jensen TM, Philipsen A, Rasmussen SS, Jørgensen ME, et al. Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care. BMC Public Health. 2012;12:1078.
Article
PubMed
PubMed Central
Google Scholar
Glümer C, Jørgensen T, Borch-Johnsen K. Inter99 study. Prevalences of diabetes and impaired glucose regulation in a Danish population: the Inter99 study. Diabetes Care. 2003;26:2335–40.
Article
PubMed
Google Scholar
Orskov C, Jeppesen J, Madsbad S, Holst JJ. Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. J Clin Invest. 1991;87:415–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Orskov C, Rabenhøj L, Wettergren A, Kofod H, Holst JJ. Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes. 1994;43:535–9.
Article
CAS
PubMed
Google Scholar
Deacon CF, Mannucci E, Ahrén B. Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis. Diabetes Obes Metab. 2012;14:762–7.
Article
CAS
PubMed
Google Scholar
Fridericia LS. The duration of systole in an electrocardiogram in normal humans and in patients with heart disease. 1920. Ann. Noninvasive Electrocardiol. Off. J. Int. Soc. Holter noninvasive Electrocardiol. Inc. 2003;8:343–51.
CAS
Google Scholar
Bezzina CR, Verkerk AO, Busjahn A, Jeron A, Erdmann J, Koopmann TT, et al. A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization. Cardiovasc Res. 2003;59:27–36.
Article
CAS
PubMed
Google Scholar
Anson BD, Ackerman MJ, Tester DJ, Will ML, Delisle BP, Anderson CL, et al. Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels. Am J Physiol Heart Circ Physiol. 2004;286:H2434–41.
Article
CAS
PubMed
Google Scholar
Paavonen KJ, Chapman H, Laitinen PJ, Fodstad H, Piippo K, Swan H, et al. Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG). Cardiovasc Res. 2003;59:603–11.
Article
CAS
PubMed
Google Scholar
Newton-Cheh C, Guo C-Y, Larson MG, Musone SL, Surti A, Camargo AL, et al. Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham heart study. Circulation. 2007;116:1128–36.
Article
CAS
PubMed
Google Scholar
Pfeufer A, Jalilzadeh S, Perz S, Mueller JC, Hinterseer M, Illig T, et al. Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study. Circ Res. 2005;96:693–701.
Article
CAS
PubMed
Google Scholar
Marjamaa A, Newton-Cheh C, Porthan K, Reunanen A, Lahermo P, Väänänen H, et al. Common candidate gene variants are associated with QT interval duration in the general population. J Intern Med. 2009;265:448–58.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gouas L, Nicaud V, Berthet M, Forhan A, Tiret L, Balkau B, et al. Association of KCNQ1, KCNE1, KCNH2 and SCN5A polymorphisms with QTc interval length in a healthy population. Eur J Hum Genet EJHG. 2005;13:1213–22.
Article
CAS
PubMed
Google Scholar
Justesen JM, Allin KH, Sandholt CH, Borglykke A, Krarup NT, Grarup N, et al. Interactions of lipid genetic risk scores with estimates of metabolic health in a Danish population. Circ Cardiovasc Genet. 2015;8:465–72.
Article
CAS
PubMed
Google Scholar
Mahendran Y, Jonsson A, Have CT, Allin KH, Witte DR, Jørgensen ME, et al. Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels. Diabetologia. 2017;60:873–8.
Article
CAS
PubMed
Google Scholar
Andersson EA, Pilgaard K, Pisinger C, Harder MN, Grarup N, Faerch K, et al. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. Diabetologia. 2010;53:1908–16.
Article
CAS
PubMed
Google Scholar
Walker JN, Ramracheya R, Zhang Q, Johnson PRV, Braun M, Rorsman P. Regulation of glucagon secretion by glucose: paracrine, intrinsic or both? Diabetes Obes Metab. 2011;13(Suppl 1):95–105.
Article
CAS
PubMed
Google Scholar
Unger RH, Orci L. Paracrinology of islets and the paracrinopathy of diabetes. Proc Natl Acad Sci U S A. 2010;107:16009–12.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rorsman P, Berggren PO, Bokvist K, Ericson H, Möhler H, Ostenson CG, et al. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature. 1989;341:233–6.
Article
CAS
PubMed
Google Scholar
Ishihara H, Maechler P, Gjinovci A, Herrera P-L, Wollheim CB. Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol. 2003;5:330–5.
Article
CAS
PubMed
Google Scholar