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Table 2 Association of unweighted genetic risk score with metabolic and incretin levels in ADDTION-PRO cohort (N = 1324)

From: Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

Trait Median (inter- quartile range) Beta (95% CI) P
GRS (n) 0 (n = 708) 1(n = 523) 2(n = 93)
Gender (male/female) 375/333 269/254 48/45 −0.01 (− 0.05, 0.04) 0.222
Age, years 67.15(62.35–72.17) 65.94 (61.64–70.96) 66.12 (61.69–70.75) − 0.79 (− 1.39, − 0.19) 0.005
BMI, kg/m2 26.88 (24.16–29.94) 26.35 (23.86–29.23) 27.73 (25.17–30.05) − 0.16 (− 0.55, 0.24) 0.443
Fasting glucose (mmol/L) 5.90 (5.56–6.40) 5.90 (5.56–6.37) 5.97 (5.56–6.47) − 0.00 (− 0.07, 0.06) 0.848
Glucose 30 min (mmol/L) 9.22 (8.10–10.30) 9.02 (7.99–10.10) 9.12 (8.10–10.03) − 0.09 (− 0.24, 0.05) 0.251
Glucose 120 min (mmol/L) 6.47 (5.25–7.99) 6.24 (5.25–7.60) 6.40 (5.20–7.70) −0.07 (− 0.26, 0.12) 0.818
Glucose AUC30min (mmol/L x min) 227.78 (205.50–247.6205) 224.73 (204.89–243.04) 226.26 (206.42–246.09) − 1.35 (− 4.23, 1.53) 0.424
Glucose AUC120min (mmol/L x min) 924.43 (828.73–1054.57) 915.71 (822.63–1030.16) 930.97 (818.05–1050.00) −8.32 (− 23.67, 7.03) 0.364
Glucose iAUC30min (mmol/L x min) 47.30 (36.62–61.04) 45.00 (33.00–59.51) 44.25 (35.09–56.46) − 1.38 (− 3.11, 0.36) 0.123
Glucose iAUC120min (mmol/L x min) 221.26 (141.00–306.71) 205.50 (129.00–296.03) 212.11 (131.23–306.00) −8.14 (− 19.59, 3.32) 0.206
Fasting Insulin (pmol/L) 39 (25–59) 35 (25–50) 38 (23–58) − 3.77 (− 6.36, − 1.18) 0.004
Insulin 30 min (pmol/L) 223 (153–334) 213 (144.5–292.5) 227 (144–335) − 8.16 (− 23.59, 7.27) 0.255
Insulin 120 min (pmol/L) 190 (115–328.5) 175 (105.5–299.5) 211 (112–294) − 5.05 (− 26.61, 16.51) 0.460
Insulin AUC30min (pmol/L x min) 4020.0 (2722.5–5842.5) 3750.0 (2602.5–5197.5) 3930 (2535–5790) − 173.04 (− 422.51, 76.43) 0.152
Insulin AUC120min (pmol/L x min) 23,535.0 (16,252.5–33,592.5) 21,832.5 (14,985.0–32,415.0) 22,080.0 (17,055.0–37,785.0) − 727.72 (− 2335.91, 880.47) 0.202
Insulin iAUC30min (pmol/L x min) 2685.0 (1755.0–4132.5) 2535.0 (1680.0–3577.5) 2700 (1770–4260) −68.56 (− 287.60, 150.49) 0.551
Insulin iAUC120min (pmol/L x min) 19,215.0 (12,570.0–26,977.5) 17,572.5 (11,700.0–26,505.0) 17,505.0 (13,020.0–27,840.0) − 309.86 (− 1765.61, 1145.89) 0.408
Fasting GLP1 (pmol/L) 12 (8–16) 12 (9–16) 12 (9–15.5) − 0.03 (− 0.55, 0.49) 0.846
GLP1 30 min (pmol/L) 27 (19–41) 27 (19–38) 28 (20–38.5) − 1.16 (− 3.59, 1.28) 0.562
GLP1 120 min (pmol/L) 20 (14–27) 19 (14–27) 21 (16–25) 0.15 (− 1.05, 1.36) 0.989
GLP1 AUC30min, pmol/L x min 615 (450–825) 600 (435–795) 645 (450–810) − 0.87 (− 3.06, 1.37) 0.443
GLP1 AUC120min (pmol/L x min) 2775 (2070–3825) 2715 (1980–3667.5) 2835 (2175–3825) − 0.62 (− 2.65, 1.44) 0.551
GLP1 iAUC30min (pmol/L x min) 225 (120–420) 210 (120–360) 225 (120–405) − 17.25 (− 52.33, 17.83) 0.946
GLP1 iAUC120min (pmol/L x min) 1305 (735–2310) 1200 (750–2077.5) 1387.5 (810–2055) −59.67 (− 230.38, 111.04) 0.929
Fasting GIP (pmol/L) 9 (7–12) 9 (6–12) 8 (6–11) −0.60 (− 1.16, − 0.04) 0.041
GIP 30 min (pmol/L) 51 (38–66) 47 (36–64) 48 (36–61) − 1.96 (− 4.10, 0.19) 0.044
GIP 120 min (pmol/L) 45 (33–59) 44 (33–59) 45 (32–60) 0.06 (− 1.78, 1.89) 0.958
GIP AUC30min (pmol/L) 900 (697.5–1170) 840 (660–1125) 855 (645–1080) − 1.77 (− 3.37, − 0.14) 0.033
GIP AUC120min (pmol/L x min) 5280 (4035–6675) 4957.5 (3915–6532.5) 5055 (3960–6345) − 1.08 (− 2.58, 0.45) 0.165
GIP iAUC30min (pmol/L x min) 615 (435–840) 585 (420–780) 585 (390–750) −19.21 (− 49.69, 11.27) 0.215
GIP iAUC120min (pmol/L x min) 4050 (2970–5407.5) 3960 (2895–5212.5) 3960 (3000–5025) −52.62 (− 233.80, 128.57) 0.527
Fasting glucagon (pmol/L) 10 (7–14) 9 (7–13) 9 (6–13.5) −1.08 (− 1.78, − 0.38) 0.005
Glucagon 30 min (pmol/L) 9 (6–12) 8 (6–11) 8.5 (6.0–12.0) −0.69 (− 1.37, − 0.02) 0. 056
Glucagon 120 min (pmol/L) 6 (4–8) 5 (4–7) 6 (4–8) − 0.36 (− 0.79, 0.07) 0.229
Glucagon AUC30min (pmol/L x min) 285 (210–390) 255 (195–360) 270 (195–375) −2.27 (− 4.21, − 0.29) 0.025
Glucagon AUC120min (pmol/L x min) 930 (690–1335) 855 (630–1185) 915 (630–1215) − 1.85 (− 3.78, 0.12) 0.066
Glucagon iAUC30min (pmol/L x min) −15 (−45–0) − 15 (− 45–15) 0 (− 45–30) 6.32 (0.87, 11.77) 0.011
Glucagon iAUC120min (pmol/L x min) −255 (− 510 - -67.5) − 240 (− 442.5 - -45) − 135 (− 420–30) 57.86 (18.95, 96.76) 0.003
  1. β, 95% and P values adjusted for age, sex and BMI. B and 95% is the effect size estimate using untransformed values. The P values were obtained from the inverse normal transformed dependent variable incretin traits and independent variable as GRS and covariates. P values < 0.05 are in bold. AUC Area under the curve. iAUC Incremental AUC. Linear regression analyses adjusted for age, sex, body mass index and the first three genome-wide principal components. AUC30min and AUC120min were log transformed and beta values given in percentage