Table 1 Association of variants (rs36210421 and rs1805123) with QT interval and metabolic changes in INTER99 cohort (n = 5487)

QTcF (ms)

− 2.4 (− 4.31 – (− 0.47))

0.016

−2.12 (− 2.91 – (− 1.33)

1.3E-07

−2.3 (− 3.05– (− 1.54)

2.2e-9

Fasting Glucose (mmol/L)

0.06 (− 0.02 – 0.14)

0.12

−0.01 (− 0.05–0.02)

0.84

−0.002 (− 0.03–0.03)

0.42

Glucose 30 min (mmol/L)

0.11 (− 0.07–0.29)

0.32

0.007 (− 0.07–0.08)

0.66

0.02 (−0.05–0.095)

0.43

Glucose 120 min (mmol/L)

0.05 (− 0.17–0.26)

0.76

−0.06 (− 0.15–0.03)

0.73

−0.05 (− 0.14–0.035)

0.88

Fasting Insulin (pmol/L)

0.57 (−2.07–3.22)

0.60

0.34 (− 0.75–1.44)

0.87

0.40 (− 0.64–1.45)

0.73

Insulin 30 min (pmol/L)

10.41 (− 7.90–28.72)

0.12

0.91 (− 6.67–8.49)

0.82

2.23 (− 4.77–9.67)

0.41

Insulin 120 min (pmol/L)

5.21 (− 15.8–26.22)

0.34

−6.86 (− 15.53–1.81)

0.32

−5.44 (− 13.71–2.84)

0.57