| |
rs36210421 (MAF = 0.031) C > A
|
rs1805123 (MAF = 0.22) T > G
|
GRS
|
|---|
|
Trait
|
β (95% CI)
|
P
|
β (95% CI)
|
P
|
β (95% CI)
|
P
|
|---|
|
QTcF (ms)
|
− 2.4 (− 4.31 – (− 0.47))
|
0.016
|
−2.12 (− 2.91 – (− 1.33)
|
1.3E-07
|
−2.3 (− 3.05– (− 1.54)
|
2.2e-9
|
|
Fasting Glucose (mmol/L)
|
0.06 (− 0.02 – 0.14)
|
0.12
|
−0.01 (− 0.05–0.02)
|
0.84
|
−0.002 (− 0.03–0.03)
|
0.42
|
|
Glucose 30 min (mmol/L)
|
0.11 (− 0.07–0.29)
|
0.32
|
0.007 (− 0.07–0.08)
|
0.66
|
0.02 (−0.05–0.095)
|
0.43
|
|
Glucose 120 min (mmol/L)
|
0.05 (− 0.17–0.26)
|
0.76
|
−0.06 (− 0.15–0.03)
|
0.73
|
−0.05 (− 0.14–0.035)
|
0.88
|
|
Fasting Insulin (pmol/L)
|
0.57 (−2.07–3.22)
|
0.60
|
0.34 (− 0.75–1.44)
|
0.87
|
0.40 (− 0.64–1.45)
|
0.73
|
|
Insulin 30 min (pmol/L)
|
10.41 (− 7.90–28.72)
|
0.12
|
0.91 (− 6.67–8.49)
|
0.82
|
2.23 (− 4.77–9.67)
|
0.41
|
|
Insulin 120 min (pmol/L)
|
5.21 (− 15.8–26.22)
|
0.34
|
−6.86 (− 15.53–1.81)
|
0.32
|
−5.44 (− 13.71–2.84)
|
0.57
|
- QTcF interval measured in milliseconds. β and P values were adjusted for age, sex and BMI. B and 95% is the effect size estimate using untransformed values. The P values were obtained from the inverse normal transformation. GRS is the additive effect of both SNPs on QT interval. β, 95% and P values adjusted for age, sex and BMI. P values < 0.05 are in bold
