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Table 1 Association of variants (rs36210421 and rs1805123) with QT interval and metabolic changes in INTER99 cohort (n = 5487)

From: Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

  rs36210421 (MAF = 0.031) C > A rs1805123 (MAF = 0.22) T > G GRS
Trait β (95% CI) P β (95% CI) P β (95% CI) P
QTcF (ms) − 2.4 (− 4.31 – (− 0.47)) 0.016 −2.12 (− 2.91 – (− 1.33) 1.3E-07 −2.3 (− 3.05– (− 1.54) 2.2e-9
Fasting Glucose (mmol/L) 0.06 (− 0.02 – 0.14) 0.12 −0.01 (− 0.05–0.02) 0.84 −0.002 (− 0.03–0.03) 0.42
Glucose 30 min (mmol/L) 0.11 (− 0.07–0.29) 0.32 0.007 (− 0.07–0.08) 0.66 0.02 (−0.05–0.095) 0.43
Glucose 120 min (mmol/L) 0.05 (− 0.17–0.26) 0.76 −0.06 (− 0.15–0.03) 0.73 −0.05 (− 0.14–0.035) 0.88
Fasting Insulin (pmol/L) 0.57 (−2.07–3.22) 0.60 0.34 (− 0.75–1.44) 0.87 0.40 (− 0.64–1.45) 0.73
Insulin 30 min (pmol/L) 10.41 (− 7.90–28.72) 0.12 0.91 (− 6.67–8.49) 0.82 2.23 (− 4.77–9.67) 0.41
Insulin 120 min (pmol/L) 5.21 (− 15.8–26.22) 0.34 −6.86 (− 15.53–1.81) 0.32 −5.44 (− 13.71–2.84) 0.57
  1. QTcF interval measured in milliseconds. β and P values were adjusted for age, sex and BMI. B and 95% is the effect size estimate using untransformed values. The P values were obtained from the inverse normal transformation. GRS is the additive effect of both SNPs on QT interval. β, 95% and P values adjusted for age, sex and BMI. P values < 0.05 are in bold