Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372(9648):1502–17.
Article
CAS
PubMed
Google Scholar
Gourraud PA, Harbo HF, Hauser SL, Baranzini SE. The genetics of multiple sclerosis: an up-to-date review. Immunol Rev. 2012;248(1):87–103.
Article
PubMed
Google Scholar
Jersild C, Svejgaard A, Fog T. HL-A antigens and multiple sclerosis. Lancet. 1972;1(7762):1240–1.
Article
CAS
PubMed
Google Scholar
International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011;476(7359):214–9.
International Multiple Sclerosis Genetics Consortium, Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013;45(11):1353–60.
Article
Google Scholar
International Multiple Sclerosis Genetics Consortium. Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. Am J Hum Genet. 2013;92(6):854–65.
Article
Google Scholar
Cookson W, Liang L, Abecasis G, Moffatt M, Lathrop M. Mapping complex disease traits with global gene expression. Nat Rev Genet. 2009;10(3):184–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, Reynolds AP, Sandstrom R, Qu H, Brody J, et al. Systematic localization of common disease-associated variation in regulatory DNA. Science. 2012;337(6099):1190–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Disanto G, Kjetil Sandve G, Ricigliano VA, Pakpoor J, Berlanga-Taylor AJ, Handel AE, Kuhle J, Holden L, Watson CT, Giovannoni G, et al. DNase hypersensitive sites and association with multiple sclerosis. Hum Mol Genet. 2014;23(4):942–8.
Article
CAS
PubMed
Google Scholar
GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 2015;348(6235):648–60.
Article
PubMed Central
Google Scholar
Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Sci Transl Med. 2015;7(287):287ra274.
Google Scholar
Ratzer R, Sondergaard HB, Christensen JR, Bornsen L, Borup R, Sorensen PS, Sellebjerg F. Gene expression analysis of relapsing-remitting, primary progressive and secondary progressive multiple sclerosis. Mult Scler. 2013;19(14):1841–8.
Article
CAS
PubMed
Google Scholar
Lo HS, Wang Z, Hu Y, Yang HH, Gere S, Buetow KH, Lee MP. Allelic variation in gene expression is common in the human genome. Genome Res. 2003;13(8):1855–62.
CAS
PubMed
PubMed Central
Google Scholar
Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2015;518(7539):337–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lappalainen T, Sammeth M, Friedlander MR, t Hoen PA, Monlong J, Rivas MA, Gonzalez-Porta M, Kurbatova N, Griebel T, Ferreira PG, et al. Transcriptome and genome sequencing uncovers functional variation in humans. Nature. 2013;501(7468):506–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Myhr KM, Grytten N, Aarseth J. The Norwegian multiple sclerosis registry and biobank. Acta Neurol Scand. 2012;126(s195):20–3.
Article
Google Scholar
Berg-Hansen P, Moen SM, Harbo HF, Celius EG. High prevalence and no latitude gradient of multiple sclerosis in Norway. Mult Scler. 2014;20(13):1780–2.
Article
CAS
PubMed
Google Scholar
Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O’Donnell CJ, de Bakker PI. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics. 2008;24(24):2938–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Riva A, Kohane IS. SNPper: retrieval and analysis of human SNPs. Bioinformatics. 2002;18(12):1681–5.
Article
CAS
PubMed
Google Scholar
Bos SD, Page CM, Andreassen BK, Elboudwarej E, Gustavsen MW, Briggs F, Quach H, Leikfoss IS, Bjolgerud A, Berge T, et al. Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis. PLoS One. 2015;10(3):e0117403.
Article
PubMed
PubMed Central
Google Scholar
Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9(7):671–5.
Article
CAS
PubMed
Google Scholar
Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S. IQGAP1: Insights into the function of a molecular puppeteer. Mol Immunol. 2015;65(2):336–49.
Article
CAS
PubMed
Google Scholar
Neel NF, Sai J, Ham AJ, Sobolik-Delmaire T, Mernaugh RL, Richmond A. IQGAP1 is a novel CXCR2-interacting protein and essential component of the “chemosynapse”. PLoS One. 2011;6(8):e23813.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bamidele AO, Kremer KN, Hirsova P, Clift IC, Gores GJ, Billadeau DD, Hedin KE. IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes. J Cell Biol. 2015;210(2):257–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chu H, Awasthi A, White 2nd GC, Chrzanowska-Wodnicka M, Malarkannan S. Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. J Immunol. 2008;181(5):3373–83.
Article
CAS
PubMed
PubMed Central
Google Scholar
Awasthi A, Samarakoon A, Chu H, Kamalakannan R, Quilliam LA, Chrzanowska-Wodnicka M, White GC, 2nd, Malarkannan S. Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. J Exp Med. 2010;207(9):1923–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Briggs FB, Leung LJ, Barcellos LF. Annotation of functional variation within non-MHC MS susceptibility loci through bioinformatics analysis. Genes Immun. 2014;15(7):466–76.
Article
CAS
PubMed
Google Scholar
Cortes M, Wong E, Koipally J, Georgopoulos K. Control of lymphocyte development by the Ikaros gene family. Curr Opin Immunol. 1999;11(2):167–71.
Article
CAS
PubMed
Google Scholar
John LB, Ward AC. The Ikaros gene family: transcriptional regulators of hematopoiesis and immunity. Mol Immunol. 2011;48(9-10):1272–8.
Article
CAS
PubMed
Google Scholar
Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, et al. Aiolos regulates B cell activation and maturation to effector state. Immunity. 1998;9(4):543–53.
Article
CAS
PubMed
Google Scholar
Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P. Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice. J Immunol. 2003;170(4):1699–706.
Article
CAS
PubMed
Google Scholar
Cariappa A, Tang M, Parng C, Nebelitskiy E, Carroll M, Georgopoulos K, Pillai S. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity. 2001;14(5):603–15.
Article
CAS
PubMed
Google Scholar
Narvi E, Nera KP, Terho P, Mustonen L, Granberg J, Lassila O. Aiolos controls gene conversion and cell death in DT40 B cells. Scand J Immunol. 2007;65(6):503–13.
Article
CAS
PubMed
Google Scholar
Kurreeman FA, Stahl EA, Okada Y, Liao K, Diogo D, Raychaudhuri S, Freudenberg J, Kochi Y, Patsopoulos NA, Gupta N, et al. Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12. Am J Hum Genet. 2012;90(3):524–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cai X, Qiao Y, Diao C, Xu X, Chen Y, Du S, Liu X, Liu N, Yu S, Chen D, et al. Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population. PLoS One. 2014;9(10):e108661.
Article
PubMed
PubMed Central
Google Scholar
Marinho S, Custovic A, Marsden P, Smith JA, Simpson A. 17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. Ann Allergy Asthma Immunol. 2012;108(6):402–411.e409.
Article
CAS
PubMed
Google Scholar
Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Li H, Rasmussen A, Williams AH, et al. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet. 2012;90(4):648–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Qiu R, Zhang H, Zhao H, Li J, Guo C, Gong Y, Liu Q. Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population. Scand J Rheumatol. 2013;42(6):469–72.
Article
CAS
PubMed
Google Scholar