Fig. 1

Consistent allelic imbalance is observed for rs907091 in IKZF3 and rs11609 in IQGAP1. ASE analyses for (a) rs11052877 in CD69, (b) rs907091 in IKZF3, and (c) rs11609 in IQGAP1 were performed in samples from whole blood from MS patients heterozygous for the indicated SNPs. Each bar represents five replicate measurements. Data are presented as the normalized change in Ct between the two alleles (nΔCt). nΔCt values above zero represents lower expression of the MS risk allele, whereas nΔCt values below zero represent higher expression of the MS risk allele. Error bars represent the standard error of the mean. Unpaired Student’s t-tests were used to compare each column with the gDNA measurement, P-values <0.05 were considered significant and are indicated with an asterisk. A > B = allele A expressed higher than B, A < B = allele A expressed lower than B