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  1. Alcohol dependence is a typical example of a complex trait that is governed by several genes and for which the mode of inheritance is unknown. We analyzed the microsatellite markers and the Affymetrix single-n...

    Authors: Konstantin Strauch, Robert Fürst, Franz Rüschendorf, Christine Windemuth, Johannes Dietter, Antonia Flaquer, Max P Baur and Thomas F Wienker
    Citation: BMC Genetics 2005 6(Suppl 1):S162
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  3. We report the results of statistical genetic analyses of data from the Collaborative Study on the Genetics of Alcoholism prepared for the Genetic Analysis Workshop 14 to detect and characterize maternally inhe...

    Authors: Loren R Lease, Deidre A Winnier, Jeff T Williams, Thomas D Dyer, Laura Almasy and Michael C Mahaney
    Citation: BMC Genetics 2005 6(Suppl 1):S158
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  4. P300 amplitude is an electrophysiological quantitative trait that is correlated with both alcoholism and smoking status. Using the Collaborative Study on the Genetics of Alcoholism data, we performed model-fre...

    Authors: Jocelyn F Bautista, Shannon RE Quade, Antonio R Parrado and Katrina AB Goddard
    Citation: BMC Genetics 2005 6(Suppl 1):S156
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  5. The overlap of 94 single-nucleotide polymorphisms (SNP) among the 4,720 and 11,120 SNPs contained in the linkage panels of Illumina and Affymetrix, respectively, allows an assessment of the discrepancy rate pr...

    Authors: Brian K Suarez, Chelsea Taylor, Sarah Bertelsen, Laura J Bierut, Gerald Dunn, Carol H Jin, John SK Kauwe, Andrew D Paterson and Anthony L Hinrichs
    Citation: BMC Genetics 2005 6(Suppl 1):S152
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  6. Two factors impacting robustness of the original transmission disequilibrium test (TDT) are: i) missing parental genotypes and ii) undetected genotype errors. While it is known that independently these factors...

    Authors: Sandra Barral, Chad Haynes, Mark A Levenstien and Derek Gordon
    Citation: BMC Genetics 2005 6(Suppl 1):S150
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  7. Genomic screens generally employ a single-locus strategy for linkage analysis, but this may have low power in the presence of epistasis. Ordered subsets analysis (OSA) is a method for conditional linkage analy...

    Authors: Svati H Shah, Michael A Schmidt, Hao Mei, William K Scott, Elizabeth R Hauser and Silke Schmidt
    Citation: BMC Genetics 2005 6(Suppl 1):S148
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  8. Complex diseases are generally thought to be under the influence of multiple, and possibly interacting, genes. Many association methods have been developed to identify susceptibility genes assuming a single-ge...

    Authors: Yan Meng, Qianli Ma, Yi Yu, John Farrell, Lindsay A Farrer and Marsha A Wilcox
    Citation: BMC Genetics 2005 6(Suppl 1):S146
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  9. Complex diseases are multifactorial in nature and can involve multiple loci with gene × gene and gene × environment interactions. Research on methods to uncover the interactions between those genes that confer...

    Authors: Guy N Brock, Brion S Maher, Toby H Goldstein, Margaret E Cooper and Mary L Marazita
    Citation: BMC Genetics 2005 6(Suppl 1):S144
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  10. The simulated dataset of the Genetic Analysis Workshop 14 provided affection status and the presence or absence of 12 traits. It was determined that all affected individuals must have traits E, F and H (EFH ph...

    Authors: Nathan Pankratz, Ellen Edenberg and Tatiana Foroud
    Citation: BMC Genetics 2005 6(Suppl 1):S142
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  11. Previous genome scan linkage analyses of the disease Kofendrerd Personality Disorder (KPD) with microsatellites led to detect some regions on chromosomes 1, 3, 5, and 9 that were identical for the three popula...

    Authors: Marie-Hélène Dizier, Emmanuelle Génin, Marie Claude Babron and Catherine Bourgain
    Citation: BMC Genetics 2005 6(Suppl 1):S140
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  12. We consider a new Bayesian approach for heterogeneity that can take into account categorical covariates, if available. We use the Genetic Analysis Workshop 14 simulated data to first compare the Bayesian appro...

    Authors: Swati Biswas, Shili Lin and Donald A Berry
    Citation: BMC Genetics 2005 6(Suppl 1):S138
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  14. In genome-wide genetic studies with a large number of markers, balancing the type I error rate and power is a challenging issue. Recently proposed false discovery rate (FDR) approaches are promising solutions ...

    Authors: Qiong Yang, Jing Cui, Irmarie Chazaro, L Adrienne Cupples and Serkalem Demissie
    Citation: BMC Genetics 2005 6(Suppl 1):S134
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  15. We applied the alternating decision trees (ADTrees) method to the last 3 replicates from the Aipotu, Danacca, Karangar, and NYC populations in the Problem 2 simulated Genetic Analysis Workshop dataset. Using i...

    Authors: Kuang-Yu Liu, Jennifer Lin, Xiaobo Zhou and Stephen TC Wong
    Citation: BMC Genetics 2005 6(Suppl 1):S132
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  16. Genome-wide association will soon be available to use as an adjunct to traditional linkage analysis. We studied alcoholism in 119 families collected by the Collaborative Study on the Genetics of Alcoholism and...

    Authors: Xiaofeng Zhu, Richard Cooper, Donghui Kan, Guichan Cao and Xiaodong Wu
    Citation: BMC Genetics 2005 6(Suppl 1):S128
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  17. We explored the evidence for a quantitative trait locus (QTL)-specific genotype × alcoholism interaction for an evoked electroencephalogram theta band oscillation (ERP) phenotype on a region of chromosome 7 in...

    Authors: Lisa J Martin, Christy L Avery, Jeff T Williams and Kari E North
    Citation: BMC Genetics 2005 6(Suppl 1):S123
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  18. We used a maximum-likelihood based multipoint linkage approach implemented in SOLAR to examine simultaneously linkage for three electrophysiological endophenotypes from the Collaborative Study of the Genetics ...

    Authors: Diane M Warren, Thomas D Dyer, Charles P Peterson, Michael C Mahaney, John Blangero and Laura Almasy
    Citation: BMC Genetics 2005 6(Suppl 1):S117
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  19. Due to the recent gains in the availability of single-nucleotide polymorphism data, genome-wide association testing has become feasible. It is hoped that this additional data may confirm the presence of diseas...

    Authors: Amy Murphy, Matthew B McQueen, Jessica Su, Peter Kraft, Ross Lazarus, Nan M Laird, Christoph Lange and Kristel Van Steen
    Citation: BMC Genetics 2005 6(Suppl 1):S115
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  20. Variance component analysis provides an efficient method for performing linkage analysis for quantitative traits. However, type I error of variance components-based likelihood ratio testing may be affected whe...

    Authors: Alfonso Buil, Thomas D Dyer, Laura Almasy and John Blangero
    Citation: BMC Genetics 2005 6(Suppl 1):S111
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  22. We studied a trend test for genetic association between disease and the number of risk alleles using case-control data. When the data are sampled from families, this trend test can be adjusted to take into acc...

    Authors: Xin Tian, Jungnam Joo, Gang Zheng and Jing-Ping Lin
    Citation: BMC Genetics 2005 6(Suppl 1):S107
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  23. We examine the efficiency of a number of schemes to select cases from nuclear families for case-control association analysis using the Genetic Analysis Workshop 14 simulated dataset. We show that with this sim...

    Authors: Rachael M Moore, Tracy Pinel, Jing Hua Zhao, Ruth March and Ansar Jawaid
    Citation: BMC Genetics 2005 6(Suppl 1):S105
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  24. For mapping complex disease traits, linkage studies are often followed by a case-control association strategy in order to identify disease-associated genes/single-nucleotide polymorphisms (SNPs). Substantial e...

    Authors: Chunyu Liu, L Adrienne Cupples and Josée Dupuis
    Citation: BMC Genetics 2005 6(Suppl 1):S103
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  25. In this paper, different strategies to test for association in samples with related individuals designed for linkage studies are compared. Because no independent controls are available, a family-based associat...

    Authors: Catherine Bourgain
    Citation: BMC Genetics 2005 6(Suppl 1):S98
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  26. Genome scans using dense single-nucleotide polymorphism (SNP) data have recently become a reality. It is thought that the increase in information content for linkage analysis as a result of the denser scans wi...

    Authors: Matthew B McQueen, Amy Murphy, Peter Kraft, Jessica Su, Ross Lazarus, Nan M Laird, Christoph Lange and Kristel Van Steen
    Citation: BMC Genetics 2005 6(Suppl 1):S96
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  27. Genotype data from the Illumina Linkage III SNP panel (n = 4,720 SNPs) and the Affymetrix 10 k mapping array (n = 11,120 SNPs) were used to test the effects of linkage disequilibrium (LD) between SNPs in a linkag...

    Authors: Sarah Shaw Murray
    Citation: BMC Genetics 2005 6(Suppl 1):S85
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  28. Most linkage programs assume linkage equilibrium among multiple linked markers. This assumption may lead to bias for tightly linked markers where strong linkage disequilibrium (LD) exists. We used simulated da...

    Authors: Qiqing Huang, Sanjay Shete, Michael Swartz and Christopher I Amos
    Citation: BMC Genetics 2005 6(Suppl 1):S83
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  29. The haplotypes of the X chromosome are accessible to direct count in males, whereas the diplotypes of the females may be inferred knowing the haplotype of their sons or fathers. Here, we investigated: 1) the p...

    Authors: Fabio Marroni, Chiara Toni, Benedetto Pennato, Ya-Yu Tsai, Pryia Duggal, Joan E Bailey-Wilson and Silvano Presciuttini
    Citation: BMC Genetics 2005 6(Suppl 1):S77
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  30. We compared seven different tagging single-nucleotide polymorphism (SNP) programs in 10 regions with varied amounts of linkage disequilibrium (LD) and physical distance. We used the Collaborative Studies on th...

    Authors: Priya Duggal, Elizabeth M Gillanders, Rasika A Mathias, Grace P Ibay, Alison P Klein, Agnes B Baffoe-Bonnie, Liang Ou, Ian P Dusenberry, Ya-Yu Tsai, Peter S Chines, Betty Q Doan and Joan E Bailey-Wilson
    Citation: BMC Genetics 2005 6(Suppl 1):S73
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  31. Our goal was to compare methods for tagging single-nucleotide polymorphisms (tagSNPs) with respect to the power to detect disease association under differing haplotype-disease association models. We were also ...

    Authors: Kelly M Burkett, Mercedeh Ghadessi, Brad McNeney, Jinko Graham and Denise Daley
    Citation: BMC Genetics 2005 6(Suppl 1):S71
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  32. It is generally assumed that the detection of disease susceptibility genes via fine-mapping association study is facilitated by consideration of marker haplotypes. In this study, we compared the performance of...

    Authors: Dushanthi Pinnaduwage and Laurent Briollais
    Citation: BMC Genetics 2005 6(Suppl 1):S65
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  33. There is great interest in the use of computationally intensive methods for fine mapping of marker data. In this paper we develop methods based upon ideas originally proposed 100 years ago in the context of sp...

    Authors: John Molitor, Keyan Zhao and Paul Marjoram
    Citation: BMC Genetics 2005 6(Suppl 1):S63
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  34. We developed a new marker-reordering algorithm to find the best order of fine-mapping markers for multipoint linkage analysis. The algorithm searches for the best order of fine-mapping markers such that the su...

    Authors: Gyungah Jun, Yeunjoo Song, Sudha K Iyengar and Robert C Elston
    Citation: BMC Genetics 2005 6(Suppl 1):S61
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  35. Using the Genetic Analysis Workshop 14 simulated datasets we carried out nonparametric linkage analyses and applied a log-linear method for analysis of case-parent-triad data with stratification on parental ma...

    Authors: Joseph Beyene, Jun Yan and Celia MT Greenwood
    Citation: BMC Genetics 2005 6(Suppl 1):S59
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  36. The information content of a continuous variable exceeds that of its categorical counterpart. The parameterization of a model may diminish the benefit of using a continuous variable. We explored the use of con...

    Authors: Kevin R Viel, Diane M Warren, Alfonso Buil, Thomas D Dyer, Tom E Howard and Laura Almasy
    Citation: BMC Genetics 2005 6(Suppl 1):S57
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  37. For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to thr...

    Authors: Albert Rosenberger, Nico Janicke, Karola Köhler, Katrin Korb, Bettina Kulle and Heike Bickeböller
    Citation: BMC Genetics 2005 6(Suppl 1):S55
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  38. For linkage analysis in affected sibling pairs, we propose a regression model to incorporate information from a disease-associated single-nucleotide polymorphism located under the linkage peak. This model can ...

    Authors: Jeanine J Houwing-Duistermaat, Hae-Won Uh, Jeremie JP Lebrec, Hein Putter and Li Hsu
    Citation: BMC Genetics 2005 6(Suppl 1):S46
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  39. The purposes of this study were 1) to examine the performance of a new multimarker regression approach for model-free linkage analysis in comparison to a conventional multipoint approach, and 2) to determine t...

    Authors: Mathew J Barber, Eleanor Wheeler and Heather J Cordell
    Citation: BMC Genetics 2005 6(Suppl 1):S40
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  40. We have developed a recursive-partitioning (RP) algorithm for identifying phenotype and covariate groupings that interact with the evidence for linkage. This data-mining approach for detecting gene × environme...

    Authors: Wei Xu, Chelsea Taylor, Justin Veenstra, Shelley B Bull, Mary Corey and Celia MT Greenwood
    Citation: BMC Genetics 2005 6(Suppl 1):S38
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  41. The basic idea of affected-sib-pair (ASP) linkage analysis is to test whether the inheritance pattern of a marker deviates from Mendelian expectation in a sample of ASPs. The test depends on an assumed Mendeli...

    Authors: Pei-Ying Shih, Tao Wang, Chao Xing, Moumita Sinha, Yeunjoo Song and Robert C Elston
    Citation: BMC Genetics 2005 6(Suppl 1):S36
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  42. A thorough genetic mapping study was performed to identify predisposing genes for alcoholism dependence using the Collaborative Study on the Genetics of Alcoholism (COGA) data. The procedure comprised whole-ge...

    Authors: Hsin-Chou Yang, Chien-Ching Chang, Chin-Yu Lin, Chun-Liang Chen, Chin-Yu Lin and Cathy SJ Fann
    Citation: BMC Genetics 2005 6(Suppl 1):S30
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  43. There is currently a great interest in using single-nucleotide polymorphisms (SNPs) in genetic linkage and association studies because of the abundance of SNPs as well as the availability of high-throughput ge...

    Authors: Shuang Wang, Song Huang, Nianjun Liu, Liang Chen, Cheongeun Oh and Hongyu Zhao
    Citation: BMC Genetics 2005 6(Suppl 1):S28
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  44. Single-nucleotide polymorphisms (SNPs) are a class of attractive genetic markers for population genetic studies and for identifying genetic variations underlying complex traits. However, the usefulness and eff...

    Authors: Nianjun Liu, Liang Chen, Shuang Wang, Cheongeun Oh and Hongyu Zhao
    Citation: BMC Genetics 2005 6(Suppl 1):S26
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  45. Using the simulated data of Problem 2 for Genetic Analysis Workshop 14 (GAW14), we investigated the ability of three bootstrap-based resampling estimators (a shrinkage, an out-of-sample, and a weighted estimat...

    Authors: Long Yang Wu, Sophia SF Lee, Haijiang Steven Shi, Lei Sun and Shelley B Bull
    Citation: BMC Genetics 2005 6(Suppl 1):S24
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  46. We compared linkage analysis results for an alcoholism trait, ALDX1 (DSM-III-R and Feigner criteria) using a nonparametric linkage analysis method, which takes into account allele sharing among several affecte...

    Authors: Ayse Ulgen and Wentian Li
    Citation: BMC Genetics 2005 6(Suppl 1):S13
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  47. We performed multipoint linkage analysis of the electrophysiological trait ECB21 on chromosome 4 in the full pedigrees provided by the Collaborative Study on the Genetics of Alcoholism (COGA). Three Markov cha...

    Authors: Weiva Sieh, Saonli Basu, Audrey Q Fu, Joseph H Rothstein, Paul A Scheet, William CL Stewart, Yun J Sung, Elizabeth A Thompson and Ellen M Wijsman
    Citation: BMC Genetics 2005 6(Suppl 1):S11
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  48. Alcoholism is a complex disease. There have been many reports on significant comorbidity between alcoholism and schizophrenia. For the genetic study of complex diseases, association analysis has been recommend...

    Authors: Junghyun Namkung, Youngchul Kim and Taesung Park
    Citation: BMC Genetics 2005 6(Suppl 1):S9
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  49. We performed linkage and linkage disequilibrium (LD) mapping analyses to compare the power between microsatellite and single nucleotide polymorphism (SNP) markers. Chromosome-wide analyses were performed for a...

    Authors: Hsiu-Fen Lin, Suh-Hang Hank Juo and Rong Cheng
    Citation: BMC Genetics 2005 6(Suppl 1):S7
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  50. The feasibility of effectively analyzing high-density single nucleotide polymorphism (SNP) maps in whole genome scans of complex traits is not known. The purpose of this study was to compare variance component...

    Authors: Helen Kim, Carolyn M Hutter, Stephanie A Monks and Karen L Edwards
    Citation: BMC Genetics 2005 6(Suppl 1):S5
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

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