Skip to main content

Articles

Page 42 of 50

  1. Genomic imprinting, which is also known as the parent-of-origin effect, is a mechanism that only expresses one copy of a gene pair depending upon the parental origin. Although many chromosomal regions in the h...

    Authors: Sanjay Shete and Robert Yu
    Citation: BMC Genetics 2005 6(Suppl 1):S161
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  2. Genetic Analysis Workshop 14 provided re-genotyped single-nucleotide polymorphism (SNP) data. Specifically, both Center for Inherited Disease Research (CIDR) and Affymetrix genotyped the same 11,560 SNPs from ...

    Authors: Nathan L Tintle, Kwangmi Ahn, Nancy Role Mendell, Derek Gordon and Stephen J Finch
    Citation: BMC Genetics 2005 6(Suppl 1):S154
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  3. Using model-based two-locus methods for mapping genes, we analyzed the family data from the Collaborative Study on the Genetics of Alcoholism. Microsatellite data from 143 families ascertained through having t...

    Authors: Chih-Chieh Wu and Sanjay Shete
    Citation: BMC Genetics 2005 6(Suppl 1):S149
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  4. Alcoholism is a serious public health problem. It has both genetic and environmental causes. In an effort to gain understanding of the underlying genetic susceptibility to alcoholism, a long-term study has bee...

    Authors: Catherine T Falk
    Citation: BMC Genetics 2005 6(Suppl 1):S131
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  5. The problem of estimating haplotype frequencies from population data has been considered by numerous investigators, resulting in a wide variety of possible algorithmic and statistical solutions. We propose a r...

    Authors: Kevin C Cartier and Daniel Baechle
    Citation: BMC Genetics 2005 6(Suppl 1):S129
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  7. Recently, alcohol-related traits have been shown to have a genetic component. Here, we study the association of specific genetic measures in one of the three sets of electrophysiological measures in families w...

    Authors: Ao Yuan, Victor Apprey, Jules P Harrell, Robert E Taylor and George E Bonney
    Citation: BMC Genetics 2005 6(Suppl 1):S126
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  8. Genetic maps based on single-nucleotide polymorphisms (SNP) are increasingly being used as an alternative to microsatellite maps. This study compares linkage results for both types of maps for a neurophysiolog...

    Authors: Gerald Dunn, Anthony L Hinrichs, Sarah Bertelsen, Carol H Jin, John SK Kauwe, Brian K Suarez and Laura J Bierut
    Citation: BMC Genetics 2005 6(Suppl 1):S122
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  9. In this paper we apply two novel quantitative trait linkage statistics based on the posterior probability of linkage (PPL) to chromosome 4 from the GAW 14 COGA dataset. Our approaches are advantageous since th...

    Authors: Christopher W Bartlett and Veronica J Vieland
    Citation: BMC Genetics 2005 6(Suppl 1):S121
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  10. A genetic analysis of age of onset of alcoholism was performed on the Collaborative Study on the Genetics of Alcoholism data released for Genetic Analysis Workshop 14. Our study illustrates an application of t...

    Authors: Victor Apprey, Joseph Afful, Jules P Harrell, Robert E Taylor and George E Bonney
    Citation: BMC Genetics 2005 6(Suppl 1):S119
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  11. Multivariate linkage analysis using several correlated traits may provide greater statistical power to detect susceptibility genes in loci whose effects are too small to be detected in univariate analysis. In ...

    Authors: Heping Zhang, Xiaoyun Zhong and Yuanqing Ye
    Citation: BMC Genetics 2005 6(Suppl 1):S118
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  12. Genetic components significantly contribute to the susceptibilities of alcoholism and its endophenotypes, such as event-related potential measures and electroencephalogram. An endophenotype is a correlated tra...

    Authors: Jing-Ping Lin and Colin Wu
    Citation: BMC Genetics 2005 6(Suppl 1):S114
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  13. Complex diseases are often reported along with disease-related traits (DRT). Sometimes investigators consider both disease and DRT phenotypes separately and sometimes they consider individuals as affected if t...

    Authors: Fei Ji, Dayoung Lee and Nancy Role Mendell
    Citation: BMC Genetics 2005 6(Suppl 1):S113
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  14. We compared the results of quantitative linkage analysis using single-nucleotide polymorphisms and microsatellite markers and introduced a new screening test for multivariate quantitative linkage analysis usin...

    Authors: Mariza de Andrade, Curtis L Olswold, Joshua P Slusser, Larry A Tordsen, Elizabeth J Atkinson, Kari G Rabe and Susan L Slager
    Citation: BMC Genetics 2005 6(Suppl 1):S112
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  15. Assigning haplotypes in a case-control study is a challenging problem. We proposed a method to quantify the information loss due to missing phase information. We determined which individuals were responsible f...

    Authors: Hae-Won Uh, Jeanine J Houwing-Duistermaat, Hein Putter and Hans C van Houwelingen
    Citation: BMC Genetics 2005 6(Suppl 1):S108
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  16. We report the analysis results of the Genetic Analysis Workshop 14 simulated microsatellite marker dataset, using replicate 50 from the Danacaa population. We applied several methods for association analysis o...

    Authors: Rachid El Galta, Li Hsu and Jeanine J Houwing-Duistermaat
    Citation: BMC Genetics 2005 6(Suppl 1):S101
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  17. This study, part of the Genetic Analysis Workshop 14 (GAW14), explored real Collaborative Study on the Genetics of Alcoholism data for linkage and association mapping between genetic polymorphisms (microsatell...

    Authors: Aldi T Kraja, Ingrid B Borecki and Michael A Province
    Citation: BMC Genetics 2005 6(Suppl 1):S94
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  18. We studied several methods for selecting single-nucleotide polymorphisms (SNPs) in a disease association study. Two major categories for analytical strategy are the univariate and the set selection approaches....

    Authors: Jungnam Joo, Xin Tian, Gang Zheng, Jing-Ping Lin and Nancy L Geller
    Citation: BMC Genetics 2005 6(Suppl 1):S93
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  19. Most methods for testing association in the presence of linkage, using family-based studies, have been developed for continuous traits. FBAT (family-based association tests) is one of few methods appropriate f...

    Authors: Gudrun Jonasdottir, Juni Palmgren and Keith Humphreys
    Citation: BMC Genetics 2005 6(Suppl 1):S92
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  20. Linkage analysis based on identity-by-descent allele-sharing can be used to identify a chromosomal region harboring a quantitative trait locus (QTL), but lacks the resolution required for gene identification. ...

    Authors: Lorena M Havill, Thomas D Dyer, Dawn K Richardson, Michael C Mahaney and John Blangero
    Citation: BMC Genetics 2005 6(Suppl 1):S91
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  21. We conducted genome-wide linkage scans using both microsatellite and single-nucleotide polymorphism (SNP) markers. Regions showing the strongest evidence of linkage to alcoholism susceptibility genes were iden...

    Authors: Yen-Feng Chiu, Su-Yun Liu and Ya-Yu Tsai
    Citation: BMC Genetics 2005 6(Suppl 1):S89
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  22. We applied three approaches for the identification of polymorphisms explaining the linkage evidence to the Genetic Analysis Workshop 14 simulated data: 1) the genotype-IBD sharing test (GIST); 2) an approach s...

    Authors: Ming-Huei Chen, Paul Van Eerdewegh and Josée Dupuis
    Citation: BMC Genetics 2005 6(Suppl 1):S88
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  23. Genetic Analysis Workshop 14 simulated data have been analyzed with MASC(marker association segregation chi-squares) in which we implemented a bootstrap procedure to provide the variation intervals of paramete...

    Authors: Mathieu Bourgey, Anne-Louise Leutenegger, Emmanuelle Cousin, Catherine Bourgain, Marie-Claude Babron and Françoise Clerget-Darpoux
    Citation: BMC Genetics 2005 6(Suppl 1):S87
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  24. This paper explores the decay of linkage disequilibrium (LD) on the autosomes and chromosome X. The extent of marker-marker LD is important for both linkage and association studies. The analysis of the Caucasi...

    Authors: Miranda E Cox, Joel K Campbell and Carl D Langefeld
    Citation: BMC Genetics 2005 6(Suppl 1):S81
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  25. Haplotype data contain signatures of ancestral alleles and increased information for mapping genes associated with complex traits. The motivation of this paper is to test the feasibility of a recently develope...

    Authors: Dajun Qian
    Citation: BMC Genetics 2005 6(Suppl 1):S79
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  26. Haplotype-based methods have become increasingly popular in the last decade because shared lengths in haplotypes can be used for disease localization. In this contribution, we propose a novel linkage-based hap...

    Authors: Andre Kleensang, Daniel Franke, Inke R König and Andreas Ziegler
    Citation: BMC Genetics 2005 6(Suppl 1):S75
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  27. Both haplotype-based and locus-based methods have been proposed as the most powerful methods to employ when fine mapping by association. Although haplotype-based methods utilize more information, they may lose...

    Authors: Keith Humphreys and Mark M Iles
    Citation: BMC Genetics 2005 6(Suppl 1):S74
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  28. Haplotypes, the combination of closely linked alleles that fall on the same chromosome, show great promise for studying the genetic components of complex diseases. However, when only multilocus genotype data a...

    Authors: Andrew S Allen and Glen A Satten
    Citation: BMC Genetics 2005 6(Suppl 1):S69
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  29. We used the FBAT (family-based association test) software to test for association between 300 individual single-nucleotide polymorphisms and P1 (a latent trait of Kofendred Personality Disorder) in 100 simulat...

    Authors: Ming-Hsi Wang, Mitchell Guo and Yin Y Shugart
    Citation: BMC Genetics 2005 6(Suppl 1):S68
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  30. We present a new method for fine-mapping a disease susceptibility locus using a case-control design. The new method, termed the weighted average (WA) statistic, averages the Cochran-Armitage (CA) trend test st...

    Authors: Kijoung Song, Mohammed S Orloff, Qing Lu and Robert C Elston
    Citation: BMC Genetics 2005 6(Suppl 1):S67
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  31. By analyzing a "pseudo-trait," a trait not linked or associated with any of the markers tested, the distribution of the test statistic under the null hypothesis can provide the critical value for the appropria...

    Authors: George J Papanicolaou, Cristina M Justice, Illija M Kovac, Alexa JM Sorant and Alexander F Wilson
    Citation: BMC Genetics 2005 6(Suppl 1):S54
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  32. In the Haseman-Elston approach the squared phenotypic difference is regressed on the proportion of alleles shared identical by descent (IBD) to map a quantitative trait to a genetic marker. In applications the...

    Authors: Daniel Franke, André Kleensang, Robert C Elston and Andreas Ziegler
    Citation: BMC Genetics 2005 6(Suppl 1):S50
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  33. The purpose of these analyses was to determine if incorporating or adjusting for covariates in genetic analyses helped or hindered in genetic analyses, specifically heritability and linkage analyses. To study ...

    Authors: Julia N Bailey
    Citation: BMC Genetics 2005 6(Suppl 1):S49
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  34. In this paper we investigate the power of finding linkage to a disease locus through analysis of the disease-related traits. We propose two family-based gene-model-free linkage statistics. Both involve conside...

    Authors: Heejong Sung, Stephen J Finch, Kenny Q Ye and Nancy R Mendell
    Citation: BMC Genetics 2005 6(Suppl 1):S47
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  35. The calculation of multipoint likelihoods is computationally challenging, with the exact calculation of multipoint probabilities only possible on small pedigrees with many markers or large pedigrees with few m...

    Authors: Andrew W George, LaVonne A Mangin, Christopher W Bartlett, Mark W Logue, Alberto M Segre and Veronica J Vieland
    Citation: BMC Genetics 2005 6(Suppl 1):S44
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  36. In order to detect linkage of the simulated complex disease Kofendrerd Personality Disorder across studies from multiple populations, we performed a genome scan meta-analysis (GSMA). Using the 7-cM microsatell...

    Authors: Margaret E Cooper, Toby H Goldstein, Brion S Maher and Mary L Marazita
    Citation: BMC Genetics 2005 6(Suppl 1):S42
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  37. We combined the results of whole-genome linkage and association analyses to determine which markers were most strongly associated with Kofendrerd Personality Disorder. Using replicate 1 from the Genetic Analys...

    Authors: Kim W Carter, Pamela A McCaskie and Lyle J Palmer
    Citation: BMC Genetics 2005 6(Suppl 1):S41
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  38. The main goal of this paper is to couple the Haseman-Elston method with a simple yet effective Bayesian factor-screening approach. This approach selects markers by considering a set of multigenic models that i...

    Authors: Seungtai Yoon, Young Ju Suh, Nancy Role Mendell and Kenny Qian Ye
    Citation: BMC Genetics 2005 6(Suppl 1):S39
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  39. In this paper, we applied the nonparametric linkage regression approach to the Caucasian genome scan data from the Collaborative Study on the Genetics of Alcoholism to search for regions of the genome that exh...

    Authors: Adrienne H Williams, W Mark Brown and Carl D Langefeld
    Citation: BMC Genetics 2005 6(Suppl 1):S37
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  40. We have developed a simulation-based approach to the analysis of shared homozygous chromosomal segments and have applied it to data on allele sharing among alcoholics in a single Collaborative Study on the Gen...

    Authors: Ondrej Libiger and Nicholas J Schork
    Citation: BMC Genetics 2005 6(Suppl 1):S35
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  41. We used the LOKI software to generate multipoint identity-by-descent matrices for a microsatellite map (with 31 markers) and two single-nucleotide polymorphism (SNP) maps to examine information content across ...

    Authors: Anthony L Hinrichs, Sarah Bertelsen, Laura J Bierut, Gerald Dunn, Carol H Jin, John S Kauwe and Brian K Suarez
    Citation: BMC Genetics 2005 6(Suppl 1):S34
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  42. Increasingly, single-nucleotide polymorphism (SNP) markers are being used in preference to microsatellite markers. However, methods developed for microsatellites may be problematic when applied to SNP markers....

    Authors: E Warwick Daw, Simon C Heath and Yue Lu
    Citation: BMC Genetics 2005 6(Suppl 1):S32
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  43. Study design strategies are of critical importance in the search for genes underlying complex diseases. Two important design choices in planning gene mapping studies are the analytic strategy to be used, which...

    Authors: Sabine Plancoulaine, Alexandre Alcaïs, Yue Chen, Laurent Abel and France Gagnon
    Citation: BMC Genetics 2005 6(Suppl 1):S22
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  44. Three variants of the confidence set inference (CSI) procedure were proposed and applied to both the simulated and the Collaborative Study on the Genetics of Alcoholism (COGA) data. For each of the two applica...

    Authors: Charalampos Papachristou and Shili Lin
    Citation: BMC Genetics 2005 6(Suppl 1):S21
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  45. The objective of this study is to evaluate the efficacy of a model-free linkage statistics for finding evidence of linkage using two different maps and to illustrate how the comparison of results from several ...

    Authors: Marie-Claude Babron, Catherine Bourgain, Anne-Louise Leutenegger and Françoise Clerget-Darpoux
    Citation: BMC Genetics 2005 6(Suppl 1):S18
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  46. The Collaborative Study on the Genetics of Alcoholism (COGA) is a large-scale family study designed to identify genes that affect the risk for alcoholism and alcohol-related phenotypes. We performed genome-wid...

    Authors: Chun Zhang, Simon Cawley, Guoying Liu, Manqiu Cao, Harley Gorrell and Giulia C Kennedy
    Citation: BMC Genetics 2005 6(Suppl 1):S17
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  47. The central issue for Genetic Analysis Workshop 14 (GAW14) is the question, which is the better strategy for linkage analysis, the use of single-nucleotide polymorphisms (SNPs) or microsatellite markers? To an...

    Authors: Qingqi Yue, Victor Apprey and George E Bonney
    Citation: BMC Genetics 2005 6(Suppl 1):S16
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  48. Alcohol dependence is a serious public health problem. We studied data from families participating in the Collaborative Study on the Genetics of Alcoholism (COGA) and made available to participants in the Gene...

    Authors: Yi Yu, Yan Meng, Qianli Ma, John Farrell, Lindsay A Farrer and Marsha A Wilcox
    Citation: BMC Genetics 2005 6(Suppl 1):S15
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  49. Using the dataset provided for Genetic Analysis Workshop 14 by the Collaborative Study on the Genetics of Alcoholism, we performed genome-wide linkage analysis of age at onset of alcoholism to compare the util...

    Authors: Bamidele O Tayo, Yulan Liang, Saverio Stranges and Maurizio Trevisan
    Citation: BMC Genetics 2005 6(Suppl 1):S12
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  50. We analyzed 143 pedigrees (364 nuclear families) in the Collaborative Study on the Genetics of Alcoholism (COGA) data provided to the participants in the Genetic Analysis Workshop 14 (GAW14) with the goal of c...

    Authors: Guanjie Chen, Adebowale Adeyemo, Jie Zhou, Ao Yuan, Yuanxiu Chen and Charles Rotimi
    Citation: BMC Genetics 2005 6(Suppl 1):S4
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

Submit manuscript

Annual Journal Metrics

  • For BMC Genetics (former title)

    2022 Citation Impact
    2.9 - 2-year Impact Factor
    3.2 - 5-year Impact Factor
    0.904 - SNIP (Source Normalized Impact per Paper)
    0.642 - SJR (SCImago Journal Rank)

    2023 Speed
    33 days submission to first editorial decision for all manuscripts (Median)
    168 days submission to accept (Median)

    2023 Usage  
    899,475 downloads
    478 Altmetric mentions

Follow

Sign up for article alerts and news from this journal

BMC Genomic Data

ISSN: 2730-6844

Contact us