Abe J, Berk BC: Reactive oxygen species as mediators of signal transduction in cardiovascular disease. Trends Cardiovasc Med. 1998, 8: 59-64. 10.1016/S1050-1738(97)00133-3.
Article
PubMed
CAS
Google Scholar
Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, Milia E, Martin-Padura I, Raker VA, Maccarana M, Petronilli V, Minucci S, Bernardi P, Lanfrancone L, Pelicci PG: A p53-p66shc signaling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene. 2002, 21: 3872-3878. 10.1038/sj.onc.1205513.
Article
PubMed
CAS
Google Scholar
Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG: The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 1999, 402: 309-313. 10.1038/46311.
Article
PubMed
CAS
Google Scholar
Migliaccio E, Mele S, Salcini AE, Pelicci G, Lai KM, Superti-Fuga G, Pawson T, Di Fiore PP, Lanfrancone L, Pelicci PG: Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor MAP kinase-fos signaling pathway. EMBO J. 1997, 16: 706-716. 10.1093/emboj/16.4.706.
Article
PubMed
CAS
PubMed Central
Google Scholar
Zaccagnini G, Martelli F, Fasanaro P, Magenta A, Gaetano C, Di Carlo A, Biglioli P, Giorgio M, Martin-Padura I, Pelicci PG, Capogrossi MC: p66ShcA modulates tissue response to hindlimb ischemia. Circulation. 2004, 109: 2917-2923. 10.1161/01.CIR.0000129309.58874.0F.
Article
PubMed
Google Scholar
Napoli C, Martin-Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, Condorelli M, Sica G, De Rosa G, Pelicci PG: Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc Natl Acad Sci. 2003, 100: 2112-2116. 10.1073/pnas.0336359100.
Article
PubMed
CAS
PubMed Central
Google Scholar
Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG: A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 1992, 70: 93-104. 10.1016/0092-8674(92)90536-L.
Article
PubMed
CAS
Google Scholar
Ventura A, Luzi L, Pacini S, Baldari CT, Pelicci PG: The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. J Biol Chem. 2002, 277: 22370-22376. 10.1074/jbc.M200280200.
Article
PubMed
CAS
Google Scholar
Graiani G, Lagrasta C, Migliaccio E, Spillmann F, Meloni M, Madeddu P, Quaini F, Padura IM, Lanfrancone L, Pelicci P, Emanueli C: Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage. Hypertension. 2005, 46: 433-440. 10.1161/01.HYP.0000174986.73346.ba.
Article
PubMed
CAS
Google Scholar
Francia P, delli Gatti C, Bachschmid M, Martin-Padura I, Savoia C, Migliaccio E, Pelicci PG, Schiavoni M, Luscher TF, Volpe M, Cosentino F: Deletion of p66shc gene protects against age-related endothelial dysfunction. Circulation. 2004, 110: 2889-95. 10.1161/01.CIR.0000147731.24444.4D.
Article
PubMed
CAS
Google Scholar
Rissanen AM: Familial occurrence of coronary artery disease: effect of age at diagnosis. Am J Cardiol. 1979, 44: 60-66. 10.1016/0002-9149(79)90251-0.
Article
PubMed
CAS
Google Scholar
Marenberg ME, Risch N, Berkman LF, Floderus B, De Faire U: Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med. 1994, 330: 1041-1046. 10.1056/NEJM199404143301503.
Article
PubMed
CAS
Google Scholar
Mooijaart SP, van Heemst D, Schreuder J, van Gerwen S, Beekman M, Brandt BW, Eline lagboom P, Westendorp RG, 'Long Life' Study Group: Variation in the SHC1 gene and longevity in humans. Exp Gerontol. 2004, 39: 263-268. 10.1016/j.exger.2003.10.001.
Article
PubMed
CAS
Google Scholar
Almind K, Ahlgren MG, Hansen T, Urhammer SA, Clausen JO, Pedersen O: Discovery of a Met300Val variant in Shc and studies of its relationship to birth weight and length, impaired insulin secretion, insulin resistance, and type 2 diabetes mellitus. J Clin Endocrinol Metab. 1999, 84: 2241-2244. 10.1210/jc.84.6.2241.
PubMed
CAS
Google Scholar
Rea IM, McKeown PP, McMaster D, Young IS, Patterson C, Savage MJ, Belton C, Marchegiani F, Olivieri F, Bonafe M, Franceschi C: Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. Exp Gerontol. 2004, 39: 629-635. 10.1016/j.exger.2003.11.019.
Article
PubMed
CAS
Google Scholar
Lio D, Candore G, Crivello A, Scola L, Colonna-Romano G, Cavallone L, Hoffmann E, Caruso M, Licastro F, Caldarera CM, Branzi A, Franceschi C, Caruso C: Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. J Med Genet. 2004, 41: 790-794. 10.1136/jmg.2004.019885.
Article
PubMed
CAS
PubMed Central
Google Scholar
Terry DF, McCormick M, Andersen S, Pennington J, Schoenhofen E, Palaima E, Bausero M, Ogawa K, Perls TT, Asea A: Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann N Y Acad Sci. 2004, 1019: 502-505. 10.1196/annals.1297.092.
Article
PubMed
CAS
PubMed Central
Google Scholar
Rose GA, Blackburn H: Cardiovascular Survey Methods. No 56. 1968, Geneva (Switzerland): World Health Organization, 1
Google Scholar
Sentinelli F, Lovari S, Vitale M, Giorgi G, Di Mario U, Baroni MG: A simple method for non-radioactive PCR-SSCP using MDE gel solution and a midi gel format: application for the detection of variants in the GLUT1 and CTLA-4 genes. J Biotechnol. 2000, 78: 201-204. 10.1016/S0168-1656(99)00241-2.
Article
PubMed
CAS
Google Scholar