Selected articles from BGRS\SB-2016: Genetics

Computational models in genetics at BGRS\SB-2016: introductory note

Authors: Yuriy L. Orlov, Ancha V. Baranova and Arcady L. Markel

A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network

Obesity is heritable. It predisposes to many diseases. The objectives of this study were to create a compendium of genes relevant to feeding behavior (FB) and/or body weight (BW) regulation; to construct and t...

Authors: Elena V. Ignatieva, Dmitry A. Afonnikov, Olga V. Saik, Evgeny I. Rogaev and Nikolay A. Kolchanov

Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells

The switch from oxidative phosphorylation to glycolysis in proliferating cancer cells, even under aerobic conditions, has been shown first in 1926 by Otto Warburg. Today this phenomenon is known as the “Warbur...

Authors: Anna V. Kudryavtseva, Maria S. Fedorova, Alex Zhavoronkov, Alexey A. Moskalev, Alexander S. Zasedatelev, Alexey A. Dmitriev, Asiya F. Sadritdinova, Irina Y. Karpova, Kirill M. Nyushko, Dmitry V. Kalinin, Nadezhda N. Volchenko, Nataliya V. Melnikova, Kseniya M. Klimina, Dmitry V. Sidorov, Anatoly Y. Popov, Tatiana V. Nasedkina…

Regulatory single nucleotide polymorphisms (rSNPs) at the promoters 1A and 1B of the human APC gene

Germline mutations in the coding sequence of the tumour suppressor APC gene give rise to familial adenomatous polyposis (which leads to colorectal cancer) and are associated with many other oncopathologies. Th...

Authors: Marina Yu Matveeva, Elena V. Kashina, Vasily V. Reshetnikov, Leonid O. Bryzgalov, Elena V. Antontseva, Natalia P. Bondar and Tatiana I. Merkulova

Genes of susceptibility to early neurodegenerative changes in the rat retina and brain: analysis by means of congenic strains

There has been considerable interest in discovery of the genetic architecture of complex traits, particularly age-related neurodegenerative disorders. To predict disease risk and to understand its genetic basi...

Authors: Elena E. Korbolina, Anna A. Zhdankina, Anzhela Zh. Fursova, Oyuna S. Kozhevnikova and Natalia G. Kolosova

The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension

The changes in the renal function leading to a reduction of medullary blood flow can have a great impact on sodium and water homeostasis and on the long-term control of arterial blood pressure. The RNA-Seq app...

Authors: Marina A. Ryazanova, Larisa A. Fedoseeva, Nikita I. Ershov, Vadim M. Efimov, Arcady L. Markel and Olga E. Redina

Genetic diversity among eight Dendrolimus species in Eurasia (Lepidoptera: Lasiocampidae) inferred from mitochondrial COI and COII, and nuclear ITS2 markers

Moths of genus Dendrolimus (Lepidoptera: Lasiocampidae) are among the major pests of coniferous forests worldwide. Taxonomy and nomenclature of this genus are not entirely established, and there are many species ...

Authors: Alexander Kononov, Kirill Ustyantsev, Baode Wang, Victor C. Mastro, Victor Fet, Alexander Blinov and Yuri Baranchikov

Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy number

SUP35 and SUP45 are essential genes encoding polypeptide chain release factors. However, mutants for these genes may be viable but display pleiotropic phenotypes which include, but are...

Authors: Polina Drozdova, Ludmila Mironova and Galina Zhouravleva