Skip to main content

Table 3 Genome-wide significant results for FEV1 in the meta-analysis. The SNP with the lowest p value within each region or gene is listed ordered by chromosome number

From: A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

SNP Position (bp) CHR Gene/Nearest Gene Coded Allele COPDGene NHW COPDGene AA Meta-Analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS
Allele Freq Beta P Allele Freq Beta P Allele Freq Beta P
rs10863398 218588279 1 TGFB2 A/A/A 0.883 −0.055 0.00539 0.695 −0.07 4.94E-05 0.202 0.067 1.06E-08
rs138641402 145445779 4 LOC646576 (near HHIP) T/T/A 0.641 −0.067 2.28E-06 0.919 −0.09 0.00479 0.668 −0.083 8.99E-15
rs6837671 89873092 4 FAM13A G/G/A 0.595 0.057 1.11E-05 0.416 0.059 0.00024 0.537 0.064 2.89E-13
rs1108581 136505241 9 DBH A/A/A 0.196 0.068 2.29E-05 0.438 0.045 0.00394 0.292 −0.058 8.72E-09
rs56077333 78899003 15 CHRNA3 A/A/A 0.649 0.089 9.49E-11 0.816 0.079 0.00014 0.318 −0.084 5.29E-18
rs8031948 78816057 15 AGPHD1 T/T/T 0.63 0.084 2.61E-10 0.838 0.05 0.02287 0.336 −0.075 2.86E-15
rs17486278 78867482 15 CHRNA5 C/C/A 0.632 0.085 1.44E-10 0.709 0.073 4.31E-05 0.647 0.079 3.48E-18
rs17487223 78923987 15 CHRNB4 T/T/T 0.616 0.081 1.82E-09 0.882 0.066 0.01205 0.353 −0.076 2.06E-14
rs2568494 78740964 15 IREB2 G/G/A 0.367 −0.076 7.25E-09 0.443 −0.028 0.07723 0.545 −0.062 1.66E-12
rs58365910 78849034 15 PSMA4 C/C/T 0.628 0.085 1.65E-10 0.747 0.045 0.01584 0.652 0.072 6.69E-15
rs56113850 41353107 19 CYP2A6 T/C/T 0.596 −0.067 0.00045 0.562 0.048 0.01985 0.458 0.067 1.51E-08
  1. The “Coded Allele” column refers to the reference allele where the first reference allele is for the COPDGene NHW cohort, the second reference allele is for the COPDGene AA cohort, and the third reference allele is for the meta-analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS