Figure 1
From: Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
Analysis of D2.Tyrp1B6GpnmbB6mice. A. D2.Tyrp1B6GpnmbB6mice (right) show a darker coat color compared to D2 mice (left) due to the presence of a wild-type Tyrp1 gene. B-C. Regions of B6-derived sequence containing Tyrp1 (B) and Gpnmb (C) are indicated by the black horizontal lines, dotted lines indicate the region within which the breakpoints lie. The estimated maximum sizes of the regions (taken from Ensembl) are indicated. Polymorphic markers flanking the breakpoint regions are shown and the orientation of the genes are indicated below.