Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus

Table 3 Concordant relationships between this and previous studies regarding ARE variants and type 2 diabetes

Age at diagnosis	Study	Sample size (n)	Ethnicity	Sex imbalance	Association of ARE variants with diabetes
Younger	Maegawa et al [12]	426	Japanese	Yes	Yes
	Xia et al [10]	930	Pima	Yes	Yes
	This study	482	Caucasian	Yes	Yes
Later	Hansen et al [15]	696	Caucasian	Yes	No
	This study	1,468	Caucasian	No	No

All studies with >200 diabetic individuals are included, 2 studies were excluded due to small sample size and lack of information regarding age of diagnosis [14, 29]. Both of these studies did present significant associations with either disease susceptibility or insulin homeostasis.

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