Wiseman J, Varley MA, Chadwick JP: Progress in Pig Science. 1998, Nottingham: Nottingham University Press, 29-38.
Google Scholar
Visscher AH, Janss LLG, Niewold TA, De Greef KH: Disease incidence and immunological traits for the selection of healthy pigs. Vet Q. 2002, 24: 29-34.
Article
CAS
PubMed
Google Scholar
Sinkora M, Butler JE, Holtmeier W, Sinkorova J: Lymphocyte development in fetal piglets: facts and surprises. Vet Immunol Immunopathol. 2005, 108 (1-2): 177-184. 10.1016/j.vetimm.2005.08.013.
Article
CAS
PubMed
Google Scholar
Alving K: Airways vasodilatation in the immediate allergic reaction. Involvement of inflammatory mediators and sensory nerves. Acta Physiol Scand Suppl. 1991, 597: 1-64.
CAS
PubMed
Google Scholar
Kenmochi T, Mullen Y, Miyamoto M, Stein E: Swine as an allotransplantation model. Veterinary Immunology and Immunopathology. 1994, 43 (1-3): 177-1831. 10.1016/0165-2427(94)90134-1.
Article
CAS
PubMed
Google Scholar
Misfeldt ML, Grimm DR: Sinclair miniature swine: an animal model of human melanoma. Vet Immunol Immunopathol. 1994, 43: 161-
Article
Google Scholar
Reinherz EL, Schlossman SF: The differentiation and function of human T lymphocytes. Cell. 1980, 19 (4): 821-827. 10.1016/0092-8674(80)90072-0.
Article
CAS
PubMed
Google Scholar
Doyle C, Strominger JL: Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature. 1987, 330 (6145): 256-259. 10.1038/330256a0.
Article
CAS
PubMed
Google Scholar
Buttini M, Westland CE, Masliah E, Yafeh AM, Wyss-Coray T, Mucke L: Novel role of human CD4 molecule identified in neurodegeneration. Nature Med. 1998, 4: 441-446. 10.1038/nm0498-441.
Article
CAS
PubMed
Google Scholar
Shedlock DJ, Shen H: Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science. 2003, 300: 337-339. 10.1126/science.1082305.
Article
CAS
PubMed
Google Scholar
Swain SL, Dutton RW, Schwab R, Yamamoto J: Xenogeneic human anti-mouse T cell responses are due to the activity of the same functional T cell subsets responsible for allospecific and major histocompatibilityrestricted responses. The Journal of Experimental Medicine. 1983, 157: 720-10.1084/jem.157.2.720.
Article
CAS
PubMed
Google Scholar
Weiss A: T lymphocyte activation. Fundamental immunology. 1997, 467-504.
Google Scholar
Unanue ER: Macrophages, antigen-presenting cells, and the phenomena of antigen handling and presentation. Fundamental immunology. 1993, 111-144.
Google Scholar
Doherty PC, Topham DJ, Tripp RA: Establishment and persistance of virus-specific CD4+and CD8+T cell memory. Immunol Rev. 1996, 150: 23-44. 10.1111/j.1600-065X.1996.tb00694.x.
Article
CAS
PubMed
Google Scholar
Ober BT, Summerfield A, Mattlinger C, Wiesmuller KH, Jung G, Pfaff E, Saalmuller A, Rziha HJ: Vaccine-induced, pseudorabies virus-specific, extrathymic CD4+CD8+ memory T-helper cells in swine. J Virol. 1998, 72 (6): 4866-4873.
PubMed Central
CAS
PubMed
Google Scholar
Yang XG, Zhang XY, Wang X: Effect of Chinese herbal medicine mixture on immune function in chickens. J Northeast Agric Univ. 2005, 36: 60-65.
Google Scholar
Hu YJ, Lin YC, Zhou GL, Yu DQ: Effect of Chinese extracts on performance and T lymphocyte cell subset of yellow broilers. China Poult. 2003, 12: 14-17.
Google Scholar
Damoiseaux JG, Cautain B, Bernard I, Mas M, Van Breda Vriesman PJ, Druet P, Fournie G, Saoudi A: A dominant role for the thymus and MHC genes in determining the peripheral CD4/CD8 T cell ratio in the rat. J Immunology. 1999, 163: 2983-
CAS
Google Scholar
Salazar RA, Souza VL, Khan AS, Fleischman JK: Role of CD4:CD8 ratio in predicting HIV co-infection in patients with newly diagnosed tuberculosis. AIDS Patient Care STDS. 2000, 14 (2): 79-83. 10.1089/108729100318000.
Article
CAS
PubMed
Google Scholar
Binns RM, Duncan IA, Powis SJ, Hutchings A, Butcher G: Subsets of null and gamma delta T-cell receptor 1 T lymphocytes in the blood of young pigs identified by specific monoclonal antibodies. Immunology. 1992, 177: 219-227.
Google Scholar
Carr MM, Howard CJ, Sopp P, Manser JM, Parsons KR: Expression of porcine g/d T lymphocytes of a phylogenetically conserved surface antigen previously restricted in expression of ruminant gd T lymphocytes. Immunology. 1994, 81: 36-40.
PubMed Central
CAS
PubMed
Google Scholar
Hirt W, Saalmüller A, Reddehase JM: Distinct g/d T cell receptors define two subsets of circulating porcine CD22CD42CD82 Tlymphocytes. J Immunology. 1990, 20: 265-269.
CAS
Google Scholar
Saalmüller A, Hirt W, Reddehase MJ: Porcine g/d T lymphocyte subsets differing in their propensity to home to the lymphoid tissue. Eur J Immunol. 1990, 20: 2343-2346. 10.1002/eji.1830201026.
Article
PubMed
Google Scholar
Sinkora J, Rehakova Z, Sinkora M, Cukrowska B, Tlaskalova-Hogenova H: Early development of immune system in pigs. Vet Immunol Immunopathol. 2002, 87 (3-4): 301-306. 10.1016/S0165-2427(02)00056-9.
Article
CAS
PubMed
Google Scholar
Summerfield A, Rziha HJ, Saalmüller A: Functional characterization of porcine CD4+CD8+ extrathymic T lymphocytes. Cell Immunol. 1996, 168: 291-296. 10.1006/cimm.1996.0078.
Article
CAS
PubMed
Google Scholar
Andersson L, Haley CS, Ellegren H, Knott SA, Johansson M, Andersson K, Andersson-Eklund L, Edfors-Lilja I, Fredholm M, Hansson I: Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science. 1994, 263: 1771-1774. 10.1126/science.8134840.
Article
CAS
PubMed
Google Scholar
Wattrang E, Almqvist M, Johansson A, Fossum C, Wallgren P, Pielberg G, Andersson L, Edfors-Lilja I: Confirmation of QTL on porcine chromosomes 1 and 8 influencing leukocyte numbers, haematological parameters and leukocyte function. Anim Genet. 2005, 36 (4): 337-345. 10.1111/j.1365-2052.2005.01315.x.
Article
CAS
PubMed
Google Scholar
Gong YF, Lu X, Wang ZP, Hu F, Luo YR, Cai SQ, Qi CM, Li S, Niu XY, Qiu XT: Detection of quantitative trait loci affecting haematological traits in swine via genome scanning. BMC Genet. 2010, 11: 56-
Article
PubMed Central
PubMed
Google Scholar
Edfors-Lilja I, Wattrang E, Marklund L, Moller M, Andersson-Eklund L, Andersson L, Fossum C: Mapping quantitative trait loci for immune capacity in the pig. J Immunology. 1998, 160: 829-835.
Google Scholar
Edfors-Lilja I, Wattrang E, Andersson L, Fossum C: Mapping quantitative trait loci for stress induced alterations in porcine leukocyte numbers and functions. Animal Genetics. 2000, 31: 186-193. 10.1046/j.1365-2052.2000.00628.x.
Article
CAS
PubMed
Google Scholar
Zou Z, Ren J, Yan X, Huang X, Yang S, Zhang Z, Yang B, Li W, Huang L: Quantitative trait loci for porcine baseline erythroid traits at three growth ages in a White Duroc 3 Erhualian F2 resource population. Mamm Genome. 2008
Google Scholar
Reiner G, Fischer R, Hepp S, Berge T, Köhler F, Willems H: Quantitative trait loci for red blood cell traits in swine. Animal Genetics. 2007, 38: 447-452. 10.1111/j.1365-2052.2007.01629.x.
Article
CAS
PubMed
Google Scholar
Reiner G, Fischer R, Hepp S, Berge T, Kohler F, Willems H: Quantitative trait loci for white blood cell numbers in swine. Anim Genet. 2008, 39 (2): 163-168. 10.1111/j.1365-2052.2008.01700.x.
Article
CAS
PubMed
Google Scholar
Lu X, Gong YF, Liu JF, Wang ZP, Hu F, Qiu XT, Luo YR, Zhang Q: Mapping quantitative trait loci for cytokines in the pig. Anim Genet. 2011, 42 (1): 1-5. 10.1111/j.1365-2052.2010.02071.x.
Article
CAS
PubMed
Google Scholar
Wilkie B, Mallard B: Selection for high immune response: an alternative approach to animal health maintenance. Vet Immunol Immunopathol. 1999, 72: 231-235. 10.1016/S0165-2427(99)00136-1.
Article
CAS
PubMed
Google Scholar
Amadori A, Zamarchi R, Chieco-Bianchi L: CD4: CD8 ratio and HIV infection: the "tap-and-drain" hypothesis. Immunol Today. 1996, 17: 414-417. 10.1016/0167-5699(96)10049-9.
Article
CAS
PubMed
Google Scholar
Evans DM, Frazer IH, Martin NG: Genetic and environmental causes of variation in basal levels of blood cells. Twin Res. 1999, 2: 250-257. 10.1375/136905299320565735.
Article
CAS
PubMed
Google Scholar
Hall MA, Ahmadi KA, Norman P, Snieder H, Macgregor A, Vaughan RW, Spector TD, Lanchbury JS: Genetic influence on peripheral blood T lymphocyte levels. Genes Immun. 2000, 1: 423-427. 10.1038/sj.gene.6363702.
Article
CAS
PubMed
Google Scholar
Ahmadi KR, Hall MA, Norman P, Vaughan RW, Snieder H, Spector TD, Lanchbury JS: Genetic determinism in the relationship between human CD4+ and CD8+ T lymphocyte populations?. Genes Immun. 2001, 2 (7): 381-387. 10.1038/sj.gene.6363796.
Article
CAS
PubMed
Google Scholar
Liu Y, Luo YR, Lu X, Qiu XT, Fu WX, Zhou JP, Liu XY, Zhang Q, Yin ZJ: Investigation and Comparative Study on Haematological Traits, Lysozyme Concentration and T Lymphocyte Subpopulation in Three Pig Breeds. Journal of Animal and Veterinary Advances. 2010, 9 (21): 2748-2751.
Article
CAS
Google Scholar
Kim JJ, Rothschild MF, Beever J, Rodriguez-Zas S, Dekkers JC: Joint analysis of two breed cross populations in pigs to improve detection and characterization of quantitative trait loci. J Anim Sci. 2005, 83 (6): 1229-1240.
CAS
PubMed
Google Scholar
Perez-Enciso M, Mercade A, Bidanel JP, Geldermann H, Cepica S, Bartenschlager H, Varona L, Milan D, Folch JM: Large-scale, multibreed, multitrait analyses of quantitative trait loci experiments: the case of porcine × chromosome. J Anim Sci. 2005, 83 (10): 2289-2296.
CAS
PubMed
Google Scholar
Walling GA, Visscher PM, Andersson L, Rothschild MF, Wang L, Moser G, Groenen MA, Bidanel JP, Cepica S, Archibald AL: Combined analyses of data from quantitative trait loci mapping studies. Chromosome 4 effects on porcine growth and fatness. Genetics. 2000, 155 (3): 1369-1378.
PubMed Central
CAS
PubMed
Google Scholar
Song XT, Evel-Kabler K, Shen L, Rollins L, Huang XF, Chen SY: A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression. Nat Med. 2008, 14 (3): 258-265. 10.1038/nm1721.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tewari K, Sacha J, Gao X, Suresh M: Effect of chronic viral infection on epitope selection, cytokine production, and surface phenotype of CD8 T cells and the role of IFN-gamma receptor in immune regulation. J Immunol. 2004, 172 (3): 1491-1500.
Article
CAS
PubMed
Google Scholar
Bulgarini D, Scalzo S, Boccoli G, Petrini M, Quaranta MT, Camagna A, Isacchi G, Testa U, Peschle C: IL-6/BSF-2 selectively stimulates the GO----S progression of CD8+ lymphocytes. J Biol Regul Homeost Agents. 1991, 5 (1): 23-33.
CAS
PubMed
Google Scholar
Thedrez A, de Lalla C, Allain S, Zaccagnino L, Sidobre S, Garavaglia C, Borsellino G, Dellabona P, Bonneville M, Scotet E: CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells. Blood. 2007, 110 (1): 251-258. 10.1182/blood-2007-01-066217.
Article
CAS
PubMed
Google Scholar
Wilkinson B, Chen JY, Han P, Rufner KM, Goularte OD, Kaye J: TOX: an HMG box protein implicated in the regulation of thymocyte selection. Nat Immunol. 2002, 3 (3): 272-280. 10.1038/ni767.
Article
CAS
PubMed
Google Scholar
Srinivas S, Dai J, Eskdale J, Gallagher GE, Megjugorac NJ, Gallagher G: Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro. Immunology. 2008, 125 (4): 492-502. 10.1111/j.1365-2567.2008.02862.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lowenthal JW, Zubler RH, Nabholz M, MacDonald HR: Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. Nature. 1985, 315 (6021): 669-672. 10.1038/315669a0.
Article
CAS
PubMed
Google Scholar
Datta S, Sarvetnick NE: IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms. PLoS One. 2008, 3 (9): e3118-10.1371/journal.pone.0003118.
Article
PubMed Central
PubMed
Google Scholar
Salem ML, Diaz-Montero CM, El-Naggar SA, Chen Y, Moussa O, Cole DJ: The TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naïve recipient mice. Vaccine. 2009, 27 (4): 549-557. 10.1016/j.vaccine.2008.11.013.
Article
PubMed Central
CAS
PubMed
Google Scholar
Apasov SG, Blackburn MR, Kellems RE, Smith PT, Sitkovsky MV: Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest. 2001, 108 (1): 131-141.
Article
PubMed Central
CAS
PubMed
Google Scholar
Botstein D, White RL, Skolnick M, Davis RW: Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet. 1980, 32 (3): 314-331.
PubMed Central
CAS
PubMed
Google Scholar
Liu J, Liu Y, Liu X, Deng HW: Bayesian Mapping of Quantitative Trait Loci for Multiple Complex Traits with the Use of Variance Components. The American Journal of Human Genetics. 2007, 81: 304-320. 10.1086/519495.
Article
CAS
PubMed
Google Scholar
Zhang Q, Hoeschele L: Multiple QTL mapping in outcross populations via residual maximum likelihood. Proc 6th World Congr Genet Appl Lives Prod. 1998, 26: 265-268.
Google Scholar
Grignola FE, Hoeschele I, Tier B: Mapping quantitative trait loci in outcross populations via residual maximum likelihood. I. Methodology. Genetics Selection Evolution. 1996, 28: 479-490. 10.1186/1297-9686-28-6-479.
Article
CAS
Google Scholar
Churchill GA, Doerge RW: Empirical threshold values for quantitative trait mapping. Genetics. 1994, 138 (3): 963-971.
PubMed Central
CAS
PubMed
Google Scholar
Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. 1995, 57: 289-300.
Google Scholar