Ueno S: Genetic polymorphisms of serotonin and dopamine transporters in mental disorders. J Med Invest. 2003, 50: 25-31.
PubMed
Google Scholar
Plomin R, Owen MJ, McGuffin P: The genetic basis of complex human behaviors. Science. 1994, 264: 1733-1739. 10.1126/science.8209254.
Article
CAS
PubMed
Google Scholar
Lesch KP: The role of serotonin transporter in modelling psychiatric disorders: focus on depression, emotion regulation, and the social brain. Experimental models in serotonin transporter research. Edited by: Kalueff A. 2009, New York: Nova Science Publishers
Google Scholar
Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996, 274: 1527-1531. 10.1126/science.274.5292.1527.
Article
CAS
PubMed
Google Scholar
Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL: Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet. 2000, 96: 202-216. 10.1002/(SICI)1096-8628(20000403)96:2<202::AID-AJMG16>3.0.CO;2-J.
Article
CAS
PubMed
Google Scholar
Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR: 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci. 2005, 8: 828-834. 10.1038/nn1463.
Article
CAS
PubMed
Google Scholar
Pezawas L, Meyer-Lindenberg A, Goldman AL, Verchinski BA, Chen G, Kolachana BS, Mattay VS, Hariri AR, Weinberger DR: Evidence of biological epistasis between BDNF and SLC6A4 and implications for depression. Mol Psychiatry. 2008, 13: 709-716. 10.1038/mp.2008.32.
Article
CAS
PubMed
Google Scholar
Bos Van den R, Homberg J, Gijsbers E, den Heijer E, Cuppen E: The effect of COMT Val(158)Met genotype on decision making and preliminary findings on its interactions with the 5-HTTLPR in healthy subjects. Neuropharmacology. 2008, 56: 493-8.
PubMed
Google Scholar
Smolka MN, Bühler M, Schumann G, Klein S, Hu XZ, Moayer M, Zimmer A, Wrase J, Flor H, Mann K, Braus DF, Goldman D, Heinz A: Gene-gene effects on central processing of aversive stimuli. Mol Psychiatry. 2007, 12: 307-317.
CAS
PubMed
Google Scholar
Benjamin J, Osher Y, Kotler M, Gritsenko I, Nemanov L, Belmaker RH, Ebstein RP: Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol-O-methyltransferase (COMT). Mol Psychiatry. 2000, 5: 96-100. 10.1038/sj.mp.4000640.
Article
CAS
PubMed
Google Scholar
Benjamin J, Osher Y, Lichtenberg P, Bachner-Melman R, Gritsenko I, Kotler M, Valsky V, Drendel M, Ebstein RP: An interaction between the catechol O-methyltransferase and serotonin transporter promoter region polymorphisms contributes to tridimensional personality questionnaire persistence scores in normal subjects. Neuropsychobiology. 2000, 41: 48-53. 10.1159/000026632.
Article
CAS
PubMed
Google Scholar
Szekely A, Ronai Z, Nemoda Z, Kolmann G, Gervai J, Sasvari-Szekely M: Human personality dimensions of persistence and harm avoidance associated with DRD4 and 5-HTTLPR polymorphisms. Am J Med Genet B Neuropsychiatr Genet. 2004, 126B: 106-110. 10.1002/ajmg.b.20134.
Article
CAS
PubMed
Google Scholar
Munafò MR, Durrant C, Lewis G, Flint J: Gene × Environment interactions at the serotonin transporter locus. Biol Psychiatry. 2008, 65: 211-9. 10.1016/j.biopsych.2008.06.009.
Article
PubMed
Google Scholar
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003, 301: 386-389. 10.1126/science.1083968.
Article
CAS
PubMed
Google Scholar
Hariri AR, Holmes A: Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci. 2006, 10: 182-191. 10.1016/j.tics.2006.02.011.
Article
PubMed
Google Scholar
Wellman CL, Izquierdo A, Garrett JE, Martin KP, Carroll J, Millstein R, Lesch KP, Murphy DL, Holmes A: Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J Neurosci. 2007, 27: 684-691. 10.1523/JNEUROSCI.4595-06.2007.
Article
CAS
PubMed
Google Scholar
Homberg JR, Bos van den R, den Heijer E, Suer R, Cuppen E: Serotonin transporter dosage modulates long-term decision-making in rat and human. Neuropharmacology. 2008, 55: 80-4. 10.1016/j.neuropharm.2008.04.016.
Article
CAS
PubMed
Google Scholar
Olivier JD, Hart Van Der MG, Van Swelm RP, Dederen PJ, Homberg JR, Cremers T, et al: A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience. 2008, 152: 573-584. 10.1016/j.neuroscience.2007.12.032.
Article
CAS
PubMed
Google Scholar
Holmes A, Lit Q, Murphy DL, Gold E, Crawley JN: Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav. 2003, 2: 365-380. 10.1046/j.1601-1848.2003.00050.x.
Article
CAS
PubMed
Google Scholar
Gill TJ, Smith GJ, Wissler RW, Kunz HW: The rat as an experimental animal. Science. 1989, 245: 269-276. 10.1126/science.2665079.
Article
PubMed
Google Scholar
Olivier JDA, Cools AR, Ellenbroek BA, Cuppen E, Homberg JR: The serotonin transporter knockout rat: a review. Experimental models in serotonin transporter research. Edited by: Kalueff A. 2009, New York: Nova Science Publishers
Google Scholar
Homberg JR, Sietse De Boer, Halfdan Raasø, Olivier JDA, Verheul M, Ronken E, Cools AR, Ellenbroek BA, Schoffelmeer ANM, Vanderschuren LJMJ, De Vries TJ, Cuppen E: Adaptations in pre- and postsynaptic 5-HT(1A) receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology. 2008, 200: 367-380. 10.1007/s00213-008-1212-x.
Article
CAS
PubMed
Google Scholar
Homberg JR, la Fleur SE, Cuppen E: Serotonin transporter deficiency increases abdominal fat in female, but not male rats. Obesity. 2009, doi:10.1016/j.neuroscience.2009.06.021,
Google Scholar
Takagi Y, Kuramoto T, Voigt B, Tsurumi T, Nakanishi S, Mashimo T, Norio M, Tadao S: An informative set of SSLP markers and genomic profiles in the rat MHC, the RT1 complex. Immunogenetics. 2009, 61: 189-97. 10.1007/s00251-008-0352-9.
Article
CAS
PubMed
Google Scholar
Nijman IJ, Kuipers S, Verheul M, Guryev V, Cuppen E: A genome-wide SNP panel for mapping and associations studies in the rat. BMC Genomics. 2008, 9: 95-10.1186/1471-2164-9-95.
Article
PubMed Central
PubMed
Google Scholar
Terenina-Rigaldie E, Moisan MP, Colas A, Beauge F, Shah KV, Jones BC, Mormede P: Genetics of behaviour: phenotypic and molecular study of rats derived from high- and low-alcohol consuming lines. Pharmacogenetics. 2003, 13: 543-54. 10.1097/00008571-200309000-00003.
Article
PubMed
Google Scholar
Piepho HP: Optimal markers density for interval mapping in a backcross population. Heredity. 2000, 84: 437-440. 10.1046/j.1365-2540.2000.00678.x.
Article
PubMed
Google Scholar
Piñeyro G, de Montigny C, Blier P: 5-HT1D receptors regulate 5-HT release in the rat raphe nuclei. In vivo voltammetry and in vitro superfusion studies. Neuropsychopharmacology. 1995, 13: 249-60. 10.1016/0893-133X(95)00109-Q.
Article
PubMed
Google Scholar
Goadsby PJ: Serotonin receptor ligands: treatments of acute migraine and cluster headache. Handb Exp Pharmacol. 2007, 177: 129-43. full_text.
Article
CAS
PubMed
Google Scholar
Kenney SP, Kekuda R, Prasad PD, Leibach FH, Devoe LD, Ganapathy V: Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta. Am J Obstet Gynecol. 1999, 181: 491-7. 10.1016/S0002-9378(99)70583-1.
Article
CAS
PubMed
Google Scholar
David V, Gold LH, Koob GF, Cazala P: Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. Neuropsychopharmacology. 2001, 24: 300-18. 10.1016/S0893-133X(00)00205-0.
Article
CAS
PubMed
Google Scholar
Hnasko TS, Sotak BN, Palmiter RD: Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin. J Neurosci. 2007, 27: 12484-8. 10.1523/JNEUROSCI.3133-07.2007.
Article
CAS
PubMed
Google Scholar
Gaspar P, Cases O, Maroteaux L: The developmental role of serotonin: news from Mouse molecular genetics. Nat Rev Neurosci. 2003, 4: 1002-1012. 10.1038/nrn1256.
Article
CAS
PubMed
Google Scholar
Rebsam A, Seif I, Gaspar P: Refinement of thamaocortical arbors and emergence of barrel domains in the primary somatosensory cortex: a study of normal and monoamine oxidase a knock-out mice. J Neurosci. 2002, 22: 8541-8552.
CAS
PubMed
Google Scholar
Persico AM, Mengual E, Moessner R, Hall FS, Revay RS, Sora I, Arellano J, DeFelipe J, Gimenez-Amaya JM, Conciatori M, Marino R, Baldi A, Cabib S, Pascucci T, Uhl GR, Murphy DL, Lesch KP, Keller F: Barrel pattern formation requires serotonin uptake by thalamocortical afferents and not vesicular monoamine release. J Neuroscience. 2001, 21: 6862-6873.
CAS
PubMed
Google Scholar
Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR: Serotonin transporter genetic variation and the response of the human amygdala. Science. 2002, 297: 400-403. 10.1126/science.1071829.
Article
CAS
PubMed
Google Scholar
Canli T, Omura K, Haas BW, Fallgatter A, Constable RT, Lesch KP: Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proc Natl Acad Sci USA. 2005, 102: 12224-12229. 10.1073/pnas.0503880102.
Article
PubMed Central
CAS
PubMed
Google Scholar
Martelli AM, Cocco L, Capitani S, Miscia S, Papa S, Manzoli FA: Nuclear phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3-kinase, Akt, and PTen: emerging key regulators of anti-apoptotic signalling and carcinogenesis. Eur J Histochem. 2007, 51 (Suppl 1): 125-31.
PubMed
Google Scholar
Page DT, Kuti OJ, Prestia C, Sur M: Haploinsufficiency for Pten and serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci USA. 2009, 106: 1989-1994. 10.1073/pnas.0804428106.
Article
PubMed Central
CAS
PubMed
Google Scholar
Baum AE, Solberg LC, Churchill GA, Ahmadiyeh N, Takahashi JS, Redei EE: Test- and behaviour-specific genetic factors affect WKY hypoactivity in tests of emotionality. Behav Brain Res. 2006, 169: 220-230. 10.1016/j.bbr.2006.01.007.
Article
PubMed Central
PubMed
Google Scholar
Vendruscolo LF, Vendruscolo JC, Terenina-Rigaldie E, Raba F, Ramos A, Takahashi RN, Mormède P: Genetic influences on behavioral and neuroendocrine responses to predator-odor stress in rats. Neurosci Lett. 2006, 409: 89-94. 10.1016/j.neulet.2006.07.026.
Article
CAS
PubMed
Google Scholar
Conti LH, Jirout M, Breen L, Vanella JJ, Schork NJ, Printz MP: Identification of quantitative trait loci for anxiety and locomotion phenotypes in rat recombinant inbred strains. Behav Genet. 2004, 34: 93-103. 10.1023/B:BEGE.0000009479.02183.1f.
Article
PubMed
Google Scholar
Zan Y, Haag JD, Chen KS, Shepel LA, Wigington D, Wang YR, Hu R, Lopez-Guajardo CC, Brose HL, Porter KI, Leonard RA, Hitt AA, Schommer SL, Elegbede AF, Gould MN: Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Nat Biotechnol. 2003, 21: 645-51. 10.1038/nbt830.
Article
CAS
PubMed
Google Scholar
Voigt B, Serikawa T: Pluripotent stem cells and other technologies will eventually open the door for straightforward gene targeting in the rat. Dis Model Mech. 2009, 2: 341-3. 10.1242/dmm.002824.
Article
CAS
PubMed
Google Scholar
Smits BM, Mudde JB, Belt van de J, Verheul M, Olivier J, Homberg J, Guryev V, Cools AR, Ellenbroek BA, Plasterk RH, Cuppen E: Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet Genomics. 2006, 16: 159-169.
CAS
PubMed
Google Scholar
Homberg JR, Olivier JD, Smits BM, Mul JD, Mudde J, Verheul M, Nieuwenhuizen OFM, Ronken E, Cremers T, Schoffelmeer ANM, Ellenbroek BA, Cuppen E: Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system. Neuroscience. 2007, 146: 1662-1676. 10.1016/j.neuroscience.2007.03.030.
Article
CAS
PubMed
Google Scholar
Jansen RC: A general Monte Carlo method for mapping multiple quantitative trait loci. Genetics. 1996, 142: 305-311.
PubMed Central
CAS
PubMed
Google Scholar
Wang SC, Basten J, Zeng Z-B: Windows QTL Cartographer 2.5. Department of Statistics. 2007, North Carolina State University, Raleigh, NC
Google Scholar