Fig. 3

A use case illustrating the retrieval of the “dishevelled” gene from EchinoDB that contains orthocluster data from 42 different echinoderm species and EchinoidDB that contains biological data of the green sea urchin L. variegatus. Dishevelled (Dvl) gene functions as a principal component of the Wnt signaling pathway that governs several cellular processes, including cell proliferation, cell differentiation, and apoptosis or cell death. a Results after searching for the keyword “dishevelled” in EchinoDB (https://echinodb.uncc.edu) [18]. In this example, the search was conducted against the repository of clusters of orthologous genes discovered from echinoderm transcriptomes. A selected record will be highlighted, and amino acid sequences from the orthocluster repository will be displayed. b Displays amino acid sequence clusters of the selected orthologous record of the “dishevelled” gene group from the EchinoDB repository. c Screenshot of the EchinoidDB main page (https://echinodb.uncc.edu/SUrchinApp/) [23]. The image shows the results after searching for the keyword “dishevelled” against the database of the green sea urchin L. variegatus. The interface allows the selection of any record on the results page to view the sequence. d Example amino acid sequence from selected record in EchinoidDB