Bioinformatical analysis of the key differentially expressed genes and associations with immune cell infiltration in development of endometriosis

Chen, Shengnan; Chai, Xiaoshan; Wu, Xianqing

doi:10.1186/s12863-022-01036-y

Table 2 Top 10 KEGG enriched gene pathways for DEGs in the GEO GSE7305, GSE7307, and GSE11691 datasets

From: Bioinformatical analysis of the key differentially expressed genes and associations with immune cell infiltration in development of endometriosis

ID	Term	Count	P value	Genes
hsa01100	Metabolic pathways	81	2.06E-10	CYP2J2\|AOX1\|AOC3\|VDR\|STAR\|HPSE2\|INMT\|ACP5\|UGT8\|LTC4S\|GGT5\|GPAT3\|NAMPT\|PLA2G2A\|P4HA3\|IDO1\|PAPSS2\|RRM2\|PDE2A\|ST6GALNAC5\|ALDH1A2\|PAPSS1\|PSAT1\|CYP11A1\|GCNT3\|DPYD\|PDE1A\|GCLC\|DPYS\|KMO\|PLA2G5\|ST6GALNAC1\|GLA\|ASRGL1\|HSD11B2\|HSD17B6\|HSD11B1\|PLPP1\|NPR1\|GSTZ1\|PLPP2\|B3GALT2\|ST3GAL4\|PLCB1\|ENPP3\|PTGIS\|CA12\|SORD\|ALDH3B2\|ENO2\|GALNT15\|PTGS2\|HMGCR\|NDUFA4L2\|GATM\|HGD\|DSE\|HSD17B2\|CNDP2\|CSGALNACT1\|NPL\|CA8\|PLD1\|UGT2B28\|PIP5K1B\|CFD\|GCNT2\|HMOX1\|ACSL5\|CYP27A1\|TYMS\|GPX3\|NNMT\|BST1\|ADH1B\|HSD3B2\|ATP6V1C2\|ASL\|CHIT1\|MAN1C1\|CYP26A1
hsa05200	Pathways In cancer	47	2.55E-12	IL7R\|RASGRP3\|PMAIP1\|PTGS2\|LAMC2\|FZD10\|SPI1\|FZD4\|FZD5\|FZD7\|MECOM\|HEY2\|PAX8\|JAK3\|CDH1\|DAPK1\|WNT2B\|TGFBR2\|IGF1\|LAMA4\|IL4R\|FOS\|CKS2\|PLCB1\|PPARG\|FGF7\|LAMC3\|LEF1\|CXCL12\|FGFR2\|FGFR3\|CTNNA2\|RPS6KA5\|EPAS1\|PLD1\|FN1\|ESR1\|CXCL8\|HMOX1\|IL6\|MET\|RAD51\|WNT2\|LPAR3\|AGTR1\|PTCH1\|LPAR4
hsa04151	PI3K-Akt signaling pathway	34	4.10E-10	IL7R\|NGF\|GHR\|ITGA7\|LAMC2\|IGF1\|LAMA4\|THBS4\|THBS2\|NTRK2\|THBS1\|JAK3\|COMP\|ANGPT1\|ERBB3\|NTF3\|PDGFD\|IL4R\|ITGB8\|NR4A1\|COL9A3\|PPP2R2C\|TNC\|FGF7\|LAMC3\|FGFR2\|FGFR3\|FN1\|IL6\|MET\|ITGA11\|LPAR3\|VWF\|LPAR4
hsa05205	Proteoglycans in cancer	28	8.15E-12	HSPB2\|FZD10\|HPSE2\|CAV2\|CAV1\|DCN\|FZD4\|FZD5\|FZD7\|TWIST2\|ANK2\|THBS1\|PPP1R12B\|WNT2B\|ERBB3\|IGF1\|CTSL\|GPC3\|MIR10A\|ITPR1\|FN1\|ESR1\|WNT2\|HOXD10\|MET\|IHH\|ANK3\|PTCH1
hsa04010	MAPK signaling pathway	27	6.35E-08	RASGRP3\|NGF\|HSPA6\|TGFBR2\|IGF1\|MAP2K6\|MAP3K8\|MECOM\|CACNA1D\|NTRK2\|DUSP4\|ANGPT1\|ERBB3\|NTF3\|PDGFD\|FOS\|NR4A1\|FGF7\|FGFR2\|FGFR3\|PTPN5\|RPS6KA5\|PTPRR\|RASGRF2\|MEF2C\|MET\|CD14
hsa04514	Cell adhesion molecules (CAMs)	26	2.64E-13	CLDN10\|CLDN11\|VCAN\|CNTNAP2\|NCAM1\|HLA-DRA\|IGSF11\|CDH1\|CDH3\|CLDN3\|CLDN4\|CLDN5\|CLDN7\|HLA-DPB1\|ITGB2\|NLGN1\|ITGB8\|NEGR1\|NFASC\|VCAM1\|SELE\|VTCN1\|PTPRC\|MAG\|HLA-DPA1\|HLA-DQA1
hsa05165	Human papillomavirus infection	26	1.56E-06	PTGS2\|ITGA7\|ITGA11\|FZD10\|CCNA2\|FZD5\|FZD7\|THBS4\|THBS2\|PARD6B\|THBS1\|COMP\|WNT2B\|LAMA4\|ITGB8\|COL9A3\|PPP2R2C\|TNC\|LAMC2\|LAMC3\|HEY2\|FN1\|WNT2\|FZD4\|ATP6V1C2\|VWF
hsa04145	Phagosome	24	2.06E-11	NCF2\|MRC1\|HLA-DRA\|C1R\|THBS4\|THBS2\|THBS1\|C3\|HLA-DPB1\|ITGB2\|CTSL\|COMP\|FCGR2B\|FCGR2A\|ATP6V1C2\|CTSS\|SCARB1\|HLA-DQA1\|CD14\|COLEC12\|COLEC11\|HLA-DPA1\|STX18\|CFD
hsa04080	Neuroactive ligand-receptor interaction	24	1.95E-05	PTGFR\|GHR\|C5AR1\|PTGDR\|ADCYAP1R1\|P2RX7\|RXFP1\|S1PR1\|ADRA2C\|C3\|EDN3\|PENK\|P2RY14\|TRH\|FPR1\|CHRM3\|ADM\|C3AR1\|GRIK2\|GABRP\|S1PR3\|LPAR3\|AGTR1\|LPAR4
hsa04610	Complement and coagulation cascades	23	8.16E-16	VSIG4\|PROS1\|C5AR1\|SERPINE1\|SERPINA1\|C4BPA\|C4BPB\|TFPI\|C3\|C7\|ITGB2\|CLU\|THBD\|CFH\|F8\|C3AR1\|CFB\|C1QB\|C1QA\|SERPING1\|C1S\|C1R\|VWF

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ISSN: 2730-6844

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