Factor | Subgroup | Sample size | OS | RFS | DMFS | PPS | ||||
---|---|---|---|---|---|---|---|---|---|---|
HR | P | HR | P | HR | P | HR | P | |||
ER status-IHC | ER positive | 3499 | 1.45 | 0.028 | 1.25 | 0.0068 | 1.26 | 0.26 | 1.84 | 0.0023 |
ER negative | 2168 | 1.28 | 0.17 | 1.2 | 0.095 | 1.53 | 0.0021 | 1.3 | 0.3 | |
ER status-array | ER positive | 5526 | 1.32 | 0.062 | 1.15 | 0.042 | 1.33 | 0.0036 | 1.52 | 0.013 |
ER negative | 2009 | 1.27 | 0.13 | 0.77 | 0.013 | 1.22 | 0.14 | 1.83 | 0.012 | |
TP53 status | mutated | 272 | 0.71 | 0.33 | 0.64 | 0.066 | 0.38 | 0.02 | 5.55 | 0.0015 |
Wild type | 388 | 0.65 | 0.17 | 1.68 | 0.02 | 0.47 | 0.035 | 2.08 | 0.048 | |
PR status | PR positive | 1559 | 1.52 | 0.27 | 1.61 | 0.0025 | 1.46 | 0.11 | 4.98 | 0.085 |
PR negative | 1989 | 0.54 | 0.042 | 1.14 | 0.25 | 1.37 | 0.038 | 0.32 | 0.022 | |
HER2 status | HER2 positive | 1273 | 1.29 | 0.18 | 0.79 | 0.047 | 1.77 | 0.00077 | 1.27 | 0.31 |
HER2 negative | 6262 | 1.28 | 0.03 | 1.11 | 0.092 | 1.26 | 0.01 | 1.48 | 0.0039 | |
Grade | Grade 1 | 576 | 0.24 | 0.041 | 1.59 | 0.18 | 4.89 | 0.018 | 0.5 | 0.23 |
Grade 2 | 1795 | 1.63 | 0.021 | 1.41 | 0.0037 | 1.38 | 0.031 | 1.97 | 0.0055 | |
Grade 3 | 2058 | 1.34 | 0.073 | 1.18 | 0.085 | 1.26 | 0.084 | 1.75 | 0.007 | |
Intrinsic subtype | Basal | 1494 | 1.49 | 0.038 | 0.79 | 0.068 | 1.25 | 0.16 | 2.01 | 0.022 |
Luminal A | 3511 | 1.32 | 0.16 | 0.88 | 0.12 | 1.31 | 0.038 | 1.77 | 0.014 | |
Luminal B | 2015 | 1.36 | 0.083 | 1.16 | 0.11 | 1.5 | 0.0071 | 1.56 | 0.12 | |
HER2+ | 515 | 0.71 | 0.25 | 0.62 | 0.0079 | 1.54 | 0.086 | 1.81 | 0.12 | |
Lymph node status | Lymph node positive | 2153 | 1.2 | 0.3 | 0.86 | 0.12 | 0.83 | 0.19 | 1.77 | 0.0055 |
Lymph node negative | 2829 | 1.71 | 0.018 | 1.4 | 0.00011 | 1.51 | 0.001 | 1.66 | 0.017 | |
Pietenpol subtype | Basal-like 1 | 418 | 2.02 | 0.1 | 0.53 | 0.014 | 0.7 | 0.26 | 2.39 | 0.2 |
Basal-like 2 | 165 | 4.51 | 0.0012 | 0.68 | 0.22 | 1.49 | 0.3 | Â | Â | |
immunomodulatory | 462 | 0.66 | 0.3 | 0.71 | 0.21 | 2.02 | 0.05 | 0.27 | 0.035 | |
Mesenchymal | 382 | 0.57 | 0.17 | 0.58 | 0.03 | 1.72 | 0.073 | 3.75 | 0.033 | |
Mesenchymal stem-like | 201 | 0.32 | 0.024 | 0.54 | 0.11 | 1.76 | 0.28 | Â | Â | |
Luminal androgen receptor | 413 | 0.8 | 0.46 | 0.71 | 0.094 | 1.89 | 0.043 | 1.67 | 0.26 |