Skip to main content

Table 1 Subgroup analysis on the correlation of CARM1 expression and prognosis of breast cancer cases

From: Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker

Factor

Subgroup

Sample size

OS

RFS

DMFS

PPS

HR

P

HR

P

HR

P

HR

P

ER status-IHC

ER positive

3499

1.45

0.028

1.25

0.0068

1.26

0.26

1.84

0.0023

ER negative

2168

1.28

0.17

1.2

0.095

1.53

0.0021

1.3

0.3

ER status-array

ER positive

5526

1.32

0.062

1.15

0.042

1.33

0.0036

1.52

0.013

ER negative

2009

1.27

0.13

0.77

0.013

1.22

0.14

1.83

0.012

TP53 status

mutated

272

0.71

0.33

0.64

0.066

0.38

0.02

5.55

0.0015

Wild type

388

0.65

0.17

1.68

0.02

0.47

0.035

2.08

0.048

PR status

PR positive

1559

1.52

0.27

1.61

0.0025

1.46

0.11

4.98

0.085

PR negative

1989

0.54

0.042

1.14

0.25

1.37

0.038

0.32

0.022

HER2 status

HER2 positive

1273

1.29

0.18

0.79

0.047

1.77

0.00077

1.27

0.31

HER2 negative

6262

1.28

0.03

1.11

0.092

1.26

0.01

1.48

0.0039

Grade

Grade 1

576

0.24

0.041

1.59

0.18

4.89

0.018

0.5

0.23

Grade 2

1795

1.63

0.021

1.41

0.0037

1.38

0.031

1.97

0.0055

Grade 3

2058

1.34

0.073

1.18

0.085

1.26

0.084

1.75

0.007

Intrinsic subtype

Basal

1494

1.49

0.038

0.79

0.068

1.25

0.16

2.01

0.022

Luminal A

3511

1.32

0.16

0.88

0.12

1.31

0.038

1.77

0.014

Luminal B

2015

1.36

0.083

1.16

0.11

1.5

0.0071

1.56

0.12

HER2+

515

0.71

0.25

0.62

0.0079

1.54

0.086

1.81

0.12

Lymph node status

Lymph node positive

2153

1.2

0.3

0.86

0.12

0.83

0.19

1.77

0.0055

Lymph node negative

2829

1.71

0.018

1.4

0.00011

1.51

0.001

1.66

0.017

Pietenpol subtype

Basal-like 1

418

2.02

0.1

0.53

0.014

0.7

0.26

2.39

0.2

Basal-like 2

165

4.51

0.0012

0.68

0.22

1.49

0.3

  

immunomodulatory

462

0.66

0.3

0.71

0.21

2.02

0.05

0.27

0.035

Mesenchymal

382

0.57

0.17

0.58

0.03

1.72

0.073

3.75

0.033

Mesenchymal stem-like

201

0.32

0.024

0.54

0.11

1.76

0.28

  

Luminal androgen receptor

413

0.8

0.46

0.71

0.094

1.89

0.043

1.67

0.26

  1. ER Estrogen receptor, PR Progesterone receptor, HER2 human epidermal growth factor receptor 2, NA not available data, HR hazard ratio
  2. The P value marked bold indicates that the prognosis of the low expression group is better than that of the high expression group, while the P value marked bold and italic indicates that the prognosis of the high expression group is better than that of the low expression group. NS, P > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.001