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Table 1 Subgroup analysis on the correlation of CARM1 expression and prognosis of breast cancer cases

From: Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker

Factor Subgroup Sample size OS RFS DMFS PPS
HR P HR P HR P HR P
ER status-IHC ER positive 3499 1.45 0.028 1.25 0.0068 1.26 0.26 1.84 0.0023
ER negative 2168 1.28 0.17 1.2 0.095 1.53 0.0021 1.3 0.3
ER status-array ER positive 5526 1.32 0.062 1.15 0.042 1.33 0.0036 1.52 0.013
ER negative 2009 1.27 0.13 0.77 0.013 1.22 0.14 1.83 0.012
TP53 status mutated 272 0.71 0.33 0.64 0.066 0.38 0.02 5.55 0.0015
Wild type 388 0.65 0.17 1.68 0.02 0.47 0.035 2.08 0.048
PR status PR positive 1559 1.52 0.27 1.61 0.0025 1.46 0.11 4.98 0.085
PR negative 1989 0.54 0.042 1.14 0.25 1.37 0.038 0.32 0.022
HER2 status HER2 positive 1273 1.29 0.18 0.79 0.047 1.77 0.00077 1.27 0.31
HER2 negative 6262 1.28 0.03 1.11 0.092 1.26 0.01 1.48 0.0039
Grade Grade 1 576 0.24 0.041 1.59 0.18 4.89 0.018 0.5 0.23
Grade 2 1795 1.63 0.021 1.41 0.0037 1.38 0.031 1.97 0.0055
Grade 3 2058 1.34 0.073 1.18 0.085 1.26 0.084 1.75 0.007
Intrinsic subtype Basal 1494 1.49 0.038 0.79 0.068 1.25 0.16 2.01 0.022
Luminal A 3511 1.32 0.16 0.88 0.12 1.31 0.038 1.77 0.014
Luminal B 2015 1.36 0.083 1.16 0.11 1.5 0.0071 1.56 0.12
HER2+ 515 0.71 0.25 0.62 0.0079 1.54 0.086 1.81 0.12
Lymph node status Lymph node positive 2153 1.2 0.3 0.86 0.12 0.83 0.19 1.77 0.0055
Lymph node negative 2829 1.71 0.018 1.4 0.00011 1.51 0.001 1.66 0.017
Pietenpol subtype Basal-like 1 418 2.02 0.1 0.53 0.014 0.7 0.26 2.39 0.2
Basal-like 2 165 4.51 0.0012 0.68 0.22 1.49 0.3   
immunomodulatory 462 0.66 0.3 0.71 0.21 2.02 0.05 0.27 0.035
Mesenchymal 382 0.57 0.17 0.58 0.03 1.72 0.073 3.75 0.033
Mesenchymal stem-like 201 0.32 0.024 0.54 0.11 1.76 0.28   
Luminal androgen receptor 413 0.8 0.46 0.71 0.094 1.89 0.043 1.67 0.26
  1. ER Estrogen receptor, PR Progesterone receptor, HER2 human epidermal growth factor receptor 2, NA not available data, HR hazard ratio
  2. The P value marked bold indicates that the prognosis of the low expression group is better than that of the high expression group, while the P value marked bold and italic indicates that the prognosis of the high expression group is better than that of the low expression group. NS, P > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.001