|
Factor
|
Subgroup
|
Sample size
|
OS
|
RFS
|
DMFS
|
PPS
|
|---|
|
HR
|
P
|
HR
|
P
|
HR
|
P
|
HR
|
P
|
|---|
|
ER status-IHC
|
ER positive
|
3499
|
1.45
|
0.028
|
1.25
|
0.0068
|
1.26
|
0.26
|
1.84
|
0.0023
|
|
ER negative
|
2168
|
1.28
|
0.17
|
1.2
|
0.095
|
1.53
|
0.0021
|
1.3
|
0.3
|
|
ER status-array
|
ER positive
|
5526
|
1.32
|
0.062
|
1.15
|
0.042
|
1.33
|
0.0036
|
1.52
|
0.013
|
|
ER negative
|
2009
|
1.27
|
0.13
|
0.77
|
0.013
|
1.22
|
0.14
|
1.83
|
0.012
|
|
TP53 status
|
mutated
|
272
|
0.71
|
0.33
|
0.64
|
0.066
|
0.38
|
0.02
|
5.55
|
0.0015
|
|
Wild type
|
388
|
0.65
|
0.17
|
1.68
|
0.02
|
0.47
|
0.035
|
2.08
|
0.048
|
|
PR status
|
PR positive
|
1559
|
1.52
|
0.27
|
1.61
|
0.0025
|
1.46
|
0.11
|
4.98
|
0.085
|
|
PR negative
|
1989
|
0.54
|
0.042
|
1.14
|
0.25
|
1.37
|
0.038
|
0.32
|
0.022
|
|
HER2 status
|
HER2 positive
|
1273
|
1.29
|
0.18
|
0.79
|
0.047
|
1.77
|
0.00077
|
1.27
|
0.31
|
|
HER2 negative
|
6262
|
1.28
|
0.03
|
1.11
|
0.092
|
1.26
|
0.01
|
1.48
|
0.0039
|
|
Grade
|
Grade 1
|
576
|
0.24
|
0.041
|
1.59
|
0.18
|
4.89
|
0.018
|
0.5
|
0.23
|
|
Grade 2
|
1795
|
1.63
|
0.021
|
1.41
|
0.0037
|
1.38
|
0.031
|
1.97
|
0.0055
|
|
Grade 3
|
2058
|
1.34
|
0.073
|
1.18
|
0.085
|
1.26
|
0.084
|
1.75
|
0.007
|
|
Intrinsic subtype
|
Basal
|
1494
|
1.49
|
0.038
|
0.79
|
0.068
|
1.25
|
0.16
|
2.01
|
0.022
|
|
Luminal A
|
3511
|
1.32
|
0.16
|
0.88
|
0.12
|
1.31
|
0.038
|
1.77
|
0.014
|
|
Luminal B
|
2015
|
1.36
|
0.083
|
1.16
|
0.11
|
1.5
|
0.0071
|
1.56
|
0.12
|
|
HER2+
|
515
|
0.71
|
0.25
|
0.62
|
0.0079
|
1.54
|
0.086
|
1.81
|
0.12
|
|
Lymph node status
|
Lymph node positive
|
2153
|
1.2
|
0.3
|
0.86
|
0.12
|
0.83
|
0.19
|
1.77
|
0.0055
|
|
Lymph node negative
|
2829
|
1.71
|
0.018
|
1.4
|
0.00011
|
1.51
|
0.001
|
1.66
|
0.017
|
|
Pietenpol subtype
|
Basal-like 1
|
418
|
2.02
|
0.1
|
0.53
|
0.014
|
0.7
|
0.26
|
2.39
|
0.2
|
|
Basal-like 2
|
165
|
4.51
|
0.0012
|
0.68
|
0.22
|
1.49
|
0.3
| | |
|
immunomodulatory
|
462
|
0.66
|
0.3
|
0.71
|
0.21
|
2.02
|
0.05
|
0.27
|
0.035
|
|
Mesenchymal
|
382
|
0.57
|
0.17
|
0.58
|
0.03
|
1.72
|
0.073
|
3.75
|
0.033
|
|
Mesenchymal stem-like
|
201
|
0.32
|
0.024
|
0.54
|
0.11
|
1.76
|
0.28
| | |
|
Luminal androgen receptor
|
413
|
0.8
|
0.46
|
0.71
|
0.094
|
1.89
|
0.043
|
1.67
|
0.26
|
- ER Estrogen receptor, PR Progesterone receptor, HER2 human epidermal growth factor receptor 2, NA not available data, HR hazard ratio
- The P value marked bold indicates that the prognosis of the low expression group is better than that of the high expression group, while the P value marked bold and italic indicates that the prognosis of the high expression group is better than that of the low expression group. NS, P > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.001
