Fig. 2

Overall re-wiring view of breast cancer-related subnetworks. For simplicity, each subnetwork was assigned by color and they were illustrated by circles. x and y axes for each heatmap show different stages or the normal condition. Each subnetwork was separated by a black line. And, the squares highlighted re-wiring changes between two conditions. In the re-wiring heatmaps, the red color indicates positive associations, the blue color indicates negative associations and the yellow color indicates weak associations among genes. In the mean expression heatmaps, the brown intensity indicates the mean expression of subnetworks