Table 2 Significant VIP variants in the Wa people compared with the other 26 populations without adjustment

rs11572325

CYP2J2

0.306375642

1.02E-06*

5.45E-06*

1.90E-06*

4.42E-06*

2.08E-05*

8.09E-05*

2.75E-06*

0.005284096*

7.76E-06*

0.009360496*

6.62E-05*

0.066258015

0.023683277*

0.011905569*

0.298107259

rs10889160

CYP2J2

0.329164673

0.002444771*

0.028881237*

0.000294247*

0.040383079*

5.88E-19*

1.08E-10*

1.52E-21*

8.72E-15*

1.62E-16*

9.67E-19*

4.46E-21*

0.113681618

0.000148487*

0.130780521

9.14E-06*

0.248614483

0.006404332*

0.108048571

0.028992767*

0.271827376

rs1760217

DPYD

0.591174047

0.635254374

0.043390478*

0.285254147

0.098440081

0.000830268*

0.083572784

0.020342952*

1.07E-05*

0.001081997*

0.013652794*

5.51E-05*

0.00026507

0.424945255

0.003384269*

3.19E-06*

0.056397577

2.18E-05*

5.35E-05*

0.00022263

0.00048027*

0.002729039*

0.021913163*

9.86E-09*

1.10E-05*

3.54E-08*

rs1801159

DPYD

0.88117013

0.950798386

0.002842988*

0.238643736

0.223227528

0.001091502*

0.018913811*

0.028486512*

6.33E-08*

0.520772569

3.62E-07*

0.002338955*

0.090969695

0.648090677

2.14E-06*

0.118531739

0.007956605*

0.000828883*

0.022882805*

0.160795921

0.068964677

1.76E-05*

8.42E-06*

4.31E-10*

3.16E-06*

2.57E-08*

rs1801265

DPYD

0.052749931

0.469459751

0.537814287

0.14153267

0.75955499

1.55E-14*

9.57E-19*

7.19E-19*

7.68E-22*

2.18E-22*

1.80E-14*

5.20E-20*

1.97E-05*

3.98E-05*

0.036349573*

8.12E-07*

0.0582413

2.03E-09*

0.010507456*

0.000166496*

0.000111818*

0.004339857*

5.32E-12*

3.10E-10*

5.62E-09*

0.001731231*

rs5275

PTGS2

0.336758749

0.417665708

0.961588522

0.118298167

0.470903061

5.37E-24*

3.85E-17*

2.15E-28*

4.85E-23*

3.89E-24*

6.60E-27*

1.08E-28*

2.24E-08*

7.96E-06*

4.18E-08*

7.32E-05*

9.47E-08*

0.016894923*

0.000783464*

2.20E-05*

0.000269579*

3.18E-08*

8.54E-08*

1.31E-06*

2.86E-13*

7.33E-09*

rs20417

PTGS2

5.38E-29

1.81E-26

1.16E-37

3.26E-27

2.82E-24

3.93E-36

5.95E-33

2.31E-19

3.44E-19

6.57E-17

1.57E-18

5.14E-15

2.82E-09

2.64E-12

2.26E-13

2.04E-16

1.85E-15

1.81E-15

1.45E-14

1.54E-19

8.50E-18

rs12139527

CACNA1S

0.010930581*

0.005747244*

0.003350606*

0.001024703*

9.11E-34*

1.29E-29*

1.83E-41*

2.75E-43*

5.74E-36*

7.83E-41*

3.31E-41*

4.94E-08*

0.001983601*

0.003138048*

0.015381705*

0.002233347*

0.038502751*

0.229113935

0.214498852

0.205806221

rs3850625

CACNA1S

9.08E-10*

4.71E-09*

2.62E-07*

4.14E-16*

2.62E-12*

1.13E-07*

4.73E-09*

5.03E-13*

4.51E-25*

2.99E-17*

4.65E-16*

1.61E-13*

rs2306238

RYR2

0.243008296

0.511988338

0.32067139

0.291217242

0.427860312

2.93E-06*

0.001321721*

7.38E-09*

1.07E-07*

5.88E-07*

5.76E-08*

3.11E-07*

0.315347468

0.004033895*

0.000709533*

0.049208479*

0.594776616

0.767314427

0.934677486

0.948399042

0.944870157

0.468046737

0.533568812

0.00731298*

0.031525792*

0.012025534*

rs2231142

ABCG2

0.759304079

0.006272733*

0.18134526

0.001634302*

0.00036571*

2.96E-09*

0.006292525*

8.53E-11*

3.58E-10*

8.53E-11*

1.12E-07*

1.30E-11*

0.093444383

0.910555607

0.363795593

0.016893966*

0.04814984*

0.003955761*

0.197481137

0.000186352*

2.64E-05*

0.098393345

0.0001759*

0.016749365*

0.015307606*

0.00252365*

rs2231137

ABCG2

0.03195508*

2.53E-07*

1.10E-05*

4.49E-17*

0.0021976*

3.93E-29*

6.69E-25*

2.40E-29*

2.26E-33*

1.72E-21*

2.40E-22*

4.17E-30*

4.32E-18*

3.98E-05*

0.21099732

8.12E-07*

1.43E-31*

2.87E-24*

2.14E-30*

1.47E-30*

7.16E-27*

1.36E-10*

7.44E-19*

9.18E-24*

1.79E-22*

1.55E-14*

rs698

ADH1C

0.014000323*

0.063405752

0.252382783

0.258458735

0.077767236

0.313321517

0.224283945

0.281282137

0.039819211*

0.004885396*

0.063702796

0.080263228

6.40E-05*

7.96E-06*

0.001138652*

7.32E-05*

1.65E-21*

1.19E-20*

1.04E-15*

1.26E-08*

1.53E-09*

0.000640869*

2.30E-07*

4.56E-06*

8.44E-11*

6.86E-12*

rs776746

CYP3A5

1.44E-20*

1.5E-18*

1.25E-18*

1.82E-21*

5.24E-21*

1.18E-37*

1.94E-33*

3.90E-43*

2.02E-40*

2.85E-40*

8.23E-39*

4.59E-45*

2.21E-13*

3.44E-19*

1.43E-09*

1.57E-18*

4.33E-06*

2.47E-06*

6.55E-07*

8.03E-08*

3.20E-07*

3.69E-22*

3.61E-20*

5.26E-21*

1.44E-19*

1.24E-20*

rs2242480

CYP3A4

0.174181201

0.021891099*

0.023739907*

0.23406711

0.435345164

2.62E-23*

1.64E-15*

3.89E-36*

1.69E-28*

1.47E-36*

6.57E-33*

1.50E-30*

0.409092294

0.192100104

1.35E-07*

0.08254084

6.01E-14*

3.60E-12*

5.94E-12*

2.02E-09*

1.22E-11*

0.17415559

0.803974761

0.115551578

0.089908531

0.456718839

rs1805123

KCNH2

0.001573873*

0.000823584*

0.056854534

1.21E-05*

1.31E-06*

0.004686145*

1.77E-07*

3.87E-08*

2.29E-09*

2.02E-09*

1.52E-06*

2.17E-08*

0.00023004*

2.36E-05*

rs4646244

NAT2

0.908457449

0.610136371

0.315761804

0.54419548

0.005511981*

0.539375881

0.681282207

0.569019305

0.731729318

0.470793074

0.766246664

0.573758645

0.765141605

0.045785995*

0.001228669*

0.743776944

0.059300297

0.228557873

0.287926694

0.380483065

0.197043557

0.719514347

0.000339744*

0.016243392*

0.0063584

3.97E-05*

rs4271002

NAT2

0.066715616

0.189042432

0.327040513

0.208044975

0.299878957

0.000159278*

0.007107265*

3.30E-10*

3.72E-10*

2.07E-05*

0.000330686*

4.77E-06*

0.000635858*

0.417562363

0.072199748

0.357070744

1.74E-06*

0.001117691*

0.077554184

0.006521172*

0.060691113

0.476861068

0.006951173*

0.000332936*

0.008015007*

0.008719915*

rs1041983

NAT2

0.3

0.101689882

0.998513527

0.036626279*

0.132118736

0.629462005

0.990184178

0.158209247

0.24464648

0.844220999

0.183124559

0.610133391

0.007677766*

0.001717351*

1.66E-05*

0.001063258*

0.00091851*

0.000817232*

0.001042721*

0.010149174*

0.001176575*

0.155505108

0.951353573

0.383411457

0.677678934

0.579411379

rs1801280

NAT2

0.356035128

4.89E-14*

4.38E-14*

2.97E-14

6.83E-19

9.29E-22

4.03E-11

2.25E-11

2.47E-21

8.41E-19

6.89E-15

4.17E-22

2.27E-25

1.72E-27

3.07E-27

1.97E-30

1.73E-26

4.00E-19

1.06E-18

8.10E-20

6.31E-25

3.64E-15

rs1799929

NAT2

0.361199143

4.69E-11*

5.21E-11*

1.75E-08*

1.49E-15*

8.89E-19*

9.21E-08*

2.85E-06*

4.54E-20*

4.43E-18*

3.32E-14*

2.50E-19*

3.12E-25*

5.32E-26*

9.84E-26*

2.87E-30*

1.73E-26*

6.28E-18*

3.27E-16*

5.98E-18*

9.49E-22*

3.69E-14*

rs1799930

NAT2

0.972002065

0.618005239

0.751795155

0.694537677

0.012320182*

0.69375469

0.192800923

0.730809

0.372603522

0.412257221

0.783101212

0.584057039

0.881554266

0.05609109

0.000190302*

0.758530406

0.111309329

0.239563334

0.199562595

0.259685706

0.456150126

0.660367076

0.000563153*

0.020071798*

0.004077679*

1.56E-05*

rs1208

NAT2

0.323358729

1.18E-20*

2.46E-17*

3.46E-22*

1.32E-27*

1.45E-27*

4E-19*

2.65E-22*

6.25E-22*

4.16E-23*

6.89E-15*

5.00E-22*

6.43E-24*

1.92E-25*

8.03E-26*

1.73E-30*

4.24E-27*

9.85E-22*

1.06E-18*

9.54E-20*

1.22E-25*

2.87E-17*

rs1799931

NAT2

0.184796686

0.049117201*

0.317619594

0.00015301*

0.47411742

2.09E-08*

3.35E-05*

6.27E-11*

8.62E-12*

1.51E-11*

8.44E-07*

4.04E-09*

7.83E-06*

0.068024303

0.013692827*

2.98E-05*

3.40E-12*

1.03E-08*

1.72E-09*

1.60E-09*

3.59E-11*

0.00114834*

2.94E-07*

9.44E-07*

1.38E-06*

1.99E-05*

rs1495741

NAT2

0.050954298

3.07932E-07*

0.011465852*

5.51E-08*

0.65417351

0.507903694

0.486579857

0.257460454

0.281747884

0.696434574

0.119487491

0.019989993*

0.041821768*

0.67785097

0.070175871

0.248664031

0.043637899*

0.00729876*

0.003075161*

5.75E-05*

0.029405924*

0.055676203

0.000771028*

0.011226574*

6.30E-06*

7.45E-05*

rs2115819

ALOX5

0.002595851*

0.000362646*

0.071696502

0.008651836*

0.093741999

1.65E-37*

8.62E-25*

4.45E-37*

5.67E-41*

9.79E-33*

1.05E-31*

5.94E-40*

3.77E-16*

9.55E-11*

9.96E-07*

1.12E-14*

5.62E-24*

3.92E-19*

3.07E-18*

6.98E-20*

8.90E-21*

9.03E-16*

6.62E-23*

1.72E-20*

9.48E-16*

2.24E-14*

rs4244285

CYP2C19

0.011385106*

0.084348706

0.104324626

0.277350778

0.037979119*

8.78E-08*

2.52E-06*

6.75E-05*

3.23E-10*

0.000120419*

6.92E-06*

1.11E-07*

9.77E-11*

2.52E-07*

4.15E-14*

8.47E-10*

2.17E-09*

0.000116625*

5.20E-08*

7.41E-09*

4.51E-13*

0.357083431

0.187693423

0.922883969

0.176804078

0.86504652

rs1057910

CYP2C9

0.199109143

0.00223127

5.21E-07*

0.000111245*

0.000272478*

rs11572103

CYP2C8

1.57E-16*

5.93E-10*

7.08E-15*

8.71E-19*

3.56E-09*

5.00E-12*

1.60E-14*

rs7909236

CYP2C8

0.001111119

0.284095031

6.35E-18*

1.17E-16*

1.77E-22*

1.70E-08*

1.45E-16*

3.59E-15*

1.16E-11*

3.98E-10*

2.96E-09*

1.61E-09*

3.50E-14*

3.03E-12*

1.49E-09*

3.17E-06*

rs17110453

CYP2C8

0.021440387*

0.826534465

0.858474033

0.794091714

0.043147139*

6.00E-20*

2.07E-14*

1.87E-20*

2.78E-24*

5.66E-22*

1.40E-19*

1.07E-22*

8.29E-11*

2.41E-07*

5.14E-14*

5.74E-10*

1.31E-11*

0.000358179*

6.93E-10*

0.000120667*

4.47E-11*

0.391440466

0.295282612

0.706742958

0.058493

0.76290557

rs3813867

CYP2E1

0.006552652*

3.59E-06*

0.000102114*

0.000102412*

2.78E-06

0.742811481

0.550417961

0.305302386

0.279166336

0.068293812

0.914073362

0.730517163

0.044163386*

0.009317049*

0.003053677*

0.452117467

0.47034354

0.246502725

0.104281398

0.044268805*

0.388354635

0.01515297*

0.004894979*

0.00523142*

0.007795656*

0.001761454*

rs2031920

CYP2E1

0.093771053

8.07E-05*

0.003359719*

0.004926448*

0.000300332*

5.35E-05*

0.016624442*

3.99E-05*

1.02E-05*

3.99E-05*

0.00015751*

1.66E-05*

0.253219685

0.120657802

0.09925265

0.219031776

0.272358474

0.037336905*

0.015728559*

0.004271931*

0.136905408

0.001606451*

0.000331478*

0.000363614*

0.000634024*

0.000111032*

rs6413432

CYP2E1

4.2E-19*

1.31E-16*

1.45E-15*

3.14E-16*

1.66E-19*

0.003915588*

0.000270607*

0.065854286

0.000530663*

6.57E-10*

4.59E-08*

9.02E-09*

2.97E-09*

1.63E-06*

1.26E-05*

0.015544772*

0.008287334*

9.51E-05*

8.46E-12*

1.83E-17*

7.76E-12*

9.13E-08*

2.51E-12*

rs2070676

CYP2E1

0.002553305*

0.827109248

0.672645828

0.614168132

0.448640164

3.81E-30*

1.06E-17*

1.00E-28*

5.52E-30*

2.70E-35*

3.78E-31*

7.09E-28*

0.290749722

0.022443644*

0.031891018*

0.002072634*

0.359414667

0.006774321*

0.034512086*

0.365848056

0.435369755

0.859781523

0.467538122

0.648934849

0.840697344

0.330668697

rs5219

KCNJ11

0.003978161*

0.000521662*

0.073272148

0.026139453*

0.041995705*

4.08E-16*

5.26E-07*

1.86E-24*

2.18E-25*

1.16E-23*

7.22E-22*

4.56E-26*

6.22E-05*

0.030526542*

0.289021265

0.002118976*

0.171703986

0.003250285*

0.047623834*

0.008845052*

0.005988539*

0.000383538*

0.000294121*

0.00355488*

3.67E-07*

0.023357634*

rs1801028

DRD2

0.002743098*

0.003159452*

0.032791444*

1.31E-13*

9.84E-09*

rs2306283

SLCO1B1

0.658512672

0.205950281

0.516381109

9.67E-06*

0.255712933

0.343484593

0.092030119

0.155670314

0.421337787

0.240886061

0.739594068

0.842983386

8.87E-16*

5.47E-20*

2.85E-16*

5.37E-13*

1.50E-21*

3.18E-19*

3.33E-24*

2.97E-22*

4.46E-25*

3.98E-10*

1.37E-11*

7.78E-09*

1.72E-17*

2.41E-11*

rs4516035

VDR

0.000250973*

1.88E-18*

9.22E-15*

3.10E-09*

7.20E-25*

2.88E-25*

7.28E-39*

1.17E-28*

3.93E-26*

4.93E-31*

1.74E-10*

3.70E-11*

1.81E-10*

1.72E-15*

7.16E-13*

rs762551

CYP1A2

0.1

0.300829362

0.634709813

0.103718477

0.314988006

0.124745263

0.69186992

0.000364292*

0.028368256*

1.00E-05*

0.037262669*

0.002040475*

0.209128456

0.032953675*

1.13E-05*

0.76149116

0.340413414

0.468062248

0.230946324

0.358933662

0.230526214

0.035152873*

0.000510748*

0.001980774*

0.003245356*

2.42E-05*

rs2472304

CYP1A2

0.014236939*

0.257348035

0.001901901*

1.73E-05*

0.004237979*

0.103421545

2.83E-16*

1.62E-07*

0.189014451

2.04E-24*

2.27E-36*

7.10E-29*

1.44E-34*

2.50E-33*

1.03E-26*

0.000626231*

0.011964466*

0.071150838

2.56E-06*

0.290829511

rs750155

SULT1A1

0.056990114

0.141351868

0.016733876*

0.351244062

0.298586001

0.550366807

0.321948571

0.002066135*

0.000560201*

0.465867078

0.097094955

0.096184189

0.005138686*

0.028868337*

3.18E-23*

0.026490062*

0.371180365

0.071724101

0.22160908

0.807754642

0.357468926

0.000453366*

0.003608286*

0.003408433*

0.049227902*

1.96E-07*

rs1800764

ACE

0.056726465

0.39143495

0.217109705

5.34E-05*

0.045931922*

2.61E-33*

8.82E-23*

1.09E-40*

1.94E-46*

1.05E-35*

2.63E-43*

7.78E-46*

4.25E-05*

0.389243603

0.47000884

1.34E-05*

6.39E-06*

4.04E-05*

0.000366475*

0.000414932*

8.38E-08*

0.016211851*

3.48E-05*

0.002243978*

0.011118101*

0.021050251*

rs4291

ACE

3.00E-30*

1.28E-35*

5.55E-31*

2.57E-26*

4.86E-35*

1.33E-28*

1.67E-29*

2.72E-30*

8.30E-26*

4.86E-35*

6.79E-26*

3.69E-35*

3.10E-29*

1.28E-34*

4.75E-42*

9.11E-29*

2.72E-30*

1.42E-24*

1.18E-31*

6.37E-28*

5.39E-31*

3.96E-29*

8.23E-28*

2.65E-35*

6.22E-30*

1.00E-28*

rs4267385

ACE

0.60706182

0.896137823

0.304531817

0.437096269

0.448897001

1.22E-24*

2.40E-15*

3.40E-26*

4.89E-32*

2.33E-33*

3.63E-30*

4.04E-30*

5.61E-06*

0.001132547*

0.876941984

3.09E-09*

2.69E-10*

1.64E-09*

1.40E-11*

1.79E-12*

7.04E-21*

0.070967336

0.001307242*

0.196898102

0.000954545*

0.008151391*

rs2108622

CYP4F2

0.688253222

0.353058471

0.579831407

0.049533921*

0.229799176

0.085598381

0.082954611

4.34E-05*

0.000977448*

0.144761136

0.129717659

0.000161974*

0.010322998*

0.071572406

0.162826967

0.004590455*

0.075664532

0.39622905

0.005888374*

2.04E-06*

2.69E-05*

1.82E-08*

1.99E-10*

2.68E-08*

1.38E-07*

1.96E-09*

rs3093105

CYP4F2

1.60E-55*

3.54E-51*

3.51E-54*

1.79E-58*

8.09E-59*

1.14E-36*

1.95E-29*

4.42E-32*

2.15E-40*

4.26E-37*

2.84E-35*

3.52E-34*

2.57E-43*

1.25E-41*

7.05E-55*

1.53E-43*

7.84E-44*

8.51E-49

1.60E-40*

6.40E-34*

1.29E-38*

4.65E-44*

1.27E-45*

1.55E-41*

1.48E-41*

1.25E-45*

rs8192726

CYP2A6

0.71094678

0.565911012

0.311301082

0.390661417

0.305375625

0.004591427*

0.245752554

0.104409227

0.002175155*

0.073757598

0.010662896*

0.10444763

0.000189151*

0.006056478*

0.00149952*

0.000247622*

0.001004263*

0.129515608

0.000373767*

0.000723061*

0.004379184*

0.496057104

0.602716704

0.243968045

0.892476883

0.243968045

rs1051298

SLC19A1

1.51E-07*

2.66E-09*

0.000482386*

3.97E-08*

2.44897E-06*

7.14E-08*

1.60E-06*

2.36E-06*

3.37E-11*

4.68E-09*

4.73E-07*

4.55E-07*

6.37E-09*

1.09E-15*

8.09E-15*

6.04E-09*

6.48E-11*

5.13E-09

5.50E-14*

4.51E-11*

2.71E-10*

1.94E-06*

7.95E-08*

2.61E-07*

3.27E-07*

2.79E-09*

rs1051296

SLC19A1

0.609205002

0.771425657

0.124768121

0.752914304

0.254101023

0.503862027

0.471517174

0.162301179

0.644086821

0.581333718

0.868173465

0.468804993

0.434021469

0.00179709

0.0062769

0.216005729

0.01134575

0.243843261

0.01625569

0.616464101

0.080496685

0.640656314

0.903856176

0.257373002

0.581655047

0.830821988

rs1131596

SLC19A1

0.022919018*

0.023544228*

0.400775632

0.005294873*

0.131694616

6.91E-11*

0.004236642*

0.000115013*

2.60E-16*

1.59E-12*

7.50E-11*

4.12E-10*

0.021820836*

2.88E-06*

8.07E-05*

0.01622849*

0.161041225

0.045935608*

9.78E-06*

0.000809244*

0.006656253*

0.01182718*

0.003770171*

0.002710073*

0.000670055*

0.002377152*

rs1065852

CYP2D6

4.20E-16

1.82E-13*

1.88E-17*

6.28E-22*

7.67E-12*

4.99E-42*

2.82E-38*

3.62E-50*

2.33E-48*

4.31E-58*

2.22E-39*

1.39E-48*

2.14E-38*

1.76E-37*

8.68E-51*

8.43E-41*

4.66E-30*

3.71E-42*

1.47E-31*

2.16E-39*

2.84E-35*

1.95E-31*

3.30E-41*

1.17E-38*

6.16E-47*

2.88E-42*