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Table 2 Significant VIP variants in the Wa people compared with the other 26 populations without adjustment

From: Genetic analysis of pharmacogenomic VIP variants in the Wa population from Yunnan Province of China

SNP ID Genes p<0.05 EAS AFR AMR EUR SAS
CDX CHB CHS JPT KHV ACB ASW ESN GWD LWK MSL YRI CLM MXL PEL PUR CEU FIN GBR IBS TSI BEB GIH ITU PJL STU
rs11572325 CYP2J2   0.306375642     1.02E-06* 5.45E-06* 1.90E-06* 4.42E-06* 2.08E-05* 8.09E-05* 2.75E-06* 0.005284096*    7.76E-06* 0.009360496* 6.62E-05* 0.066258015 0.023683277* 0.011905569*    0.298107259   
rs10889160 CYP2J2 0.329164673 0.002444771* 0.028881237* 0.000294247* 0.040383079* 5.88E-19* 1.08E-10* 1.52E-21* 8.72E-15* 1.62E-16* 9.67E-19* 4.46E-21* 0.113681618    0.000148487* 0.130780521 9.14E-06* 0.248614483 0.006404332* 0.108048571    0.028992767* 0.271827376  
rs1760217 DPYD 0.591174047 0.635254374 0.043390478* 0.285254147 0.098440081 0.000830268* 0.083572784 0.020342952* 1.07E-05* 0.001081997* 0.013652794* 5.51E-05* 0.00026507 0.424945255 0.003384269* 3.19E-06* 0.056397577 2.18E-05* 5.35E-05* 0.00022263 0.00048027* 0.002729039* 0.021913163* 9.86E-09* 1.10E-05* 3.54E-08*
rs1801159 DPYD 0.88117013 0.950798386 0.002842988* 0.238643736 0.223227528 0.001091502* 0.018913811* 0.028486512* 6.33E-08* 0.520772569 3.62E-07* 0.002338955* 0.090969695 0.648090677 2.14E-06* 0.118531739 0.007956605* 0.000828883* 0.022882805* 0.160795921 0.068964677 1.76E-05* 8.42E-06* 4.31E-10* 3.16E-06* 2.57E-08*
rs1801265 DPYD 0.052749931 0.469459751 0.537814287 0.14153267 0.75955499 1.55E-14* 9.57E-19* 7.19E-19* 7.68E-22* 2.18E-22* 1.80E-14* 5.20E-20* 1.97E-05* 3.98E-05* 0.036349573* 8.12E-07* 0.0582413 2.03E-09* 0.010507456* 0.000166496* 0.000111818* 0.004339857* 5.32E-12* 3.10E-10* 5.62E-09* 0.001731231*
rs5275 PTGS2 0.336758749 0.417665708 0.961588522 0.118298167 0.470903061 5.37E-24* 3.85E-17* 2.15E-28* 4.85E-23* 3.89E-24* 6.60E-27* 1.08E-28* 2.24E-08* 7.96E-06* 4.18E-08* 7.32E-05* 9.47E-08* 0.016894923* 0.000783464* 2.20E-05* 0.000269579* 3.18E-08* 8.54E-08* 1.31E-06* 2.86E-13* 7.33E-09*
rs20417 PTGS2       5.38E-29 1.81E-26 1.16E-37 3.26E-27 2.82E-24 3.93E-36 5.95E-33 2.31E-19 3.44E-19 6.57E-17 1.57E-18 5.14E-15 2.82E-09 2.64E-12 2.26E-13 2.04E-16 1.85E-15 1.81E-15 1.45E-14 1.54E-19 8.50E-18
rs12139527 CACNA1S 0.010930581* 0.005747244* 0.003350606* 0.001024703*   9.11E-34* 1.29E-29* 1.83E-41* 2.75E-43* 5.74E-36* 7.83E-41* 3.31E-41*     4.94E-08* 0.001983601* 0.003138048* 0.015381705* 0.002233347* 0.038502751*   0.229113935   0.214498852 0.205806221
rs3850625 CACNA1S              9.08E-10*   4.71E-09*   2.62E-07* 4.14E-16* 2.62E-12* 1.13E-07* 4.73E-09* 5.03E-13* 4.51E-25* 2.99E-17* 4.65E-16* 1.61E-13*
rs2306238 RYR2 0.243008296 0.511988338 0.32067139 0.291217242 0.427860312 2.93E-06* 0.001321721* 7.38E-09* 1.07E-07* 5.88E-07* 5.76E-08* 3.11E-07* 0.315347468 0.004033895* 0.000709533* 0.049208479* 0.594776616 0.767314427 0.934677486 0.948399042 0.944870157 0.468046737 0.533568812 0.00731298* 0.031525792* 0.012025534*
rs2231142 ABCG2 0.759304079 0.006272733* 0.18134526 0.001634302* 0.00036571* 2.96E-09* 0.006292525* 8.53E-11* 3.58E-10* 8.53E-11* 1.12E-07* 1.30E-11* 0.093444383 0.910555607 0.363795593 0.016893966* 0.04814984* 0.003955761* 0.197481137 0.000186352* 2.64E-05* 0.098393345 0.0001759* 0.016749365* 0.015307606* 0.00252365*
rs2231137 ABCG2 0.03195508* 2.53E-07* 1.10E-05* 4.49E-17* 0.0021976* 3.93E-29* 6.69E-25* 2.40E-29* 2.26E-33* 1.72E-21* 2.40E-22* 4.17E-30* 4.32E-18* 3.98E-05* 0.21099732 8.12E-07* 1.43E-31* 2.87E-24* 2.14E-30* 1.47E-30* 7.16E-27* 1.36E-10* 7.44E-19* 9.18E-24* 1.79E-22* 1.55E-14*
rs698 ADH1C 0.014000323* 0.063405752 0.252382783 0.258458735 0.077767236 0.313321517 0.224283945 0.281282137 0.039819211* 0.004885396* 0.063702796 0.080263228 6.40E-05* 7.96E-06* 0.001138652* 7.32E-05* 1.65E-21* 1.19E-20* 1.04E-15* 1.26E-08* 1.53E-09* 0.000640869* 2.30E-07* 4.56E-06* 8.44E-11* 6.86E-12*
rs776746 CYP3A5 1.44E-20* 1.5E-18* 1.25E-18* 1.82E-21* 5.24E-21* 1.18E-37* 1.94E-33* 3.90E-43* 2.02E-40* 2.85E-40* 8.23E-39* 4.59E-45* 2.21E-13* 3.44E-19* 1.43E-09* 1.57E-18* 4.33E-06* 2.47E-06* 6.55E-07* 8.03E-08* 3.20E-07* 3.69E-22* 3.61E-20* 5.26E-21* 1.44E-19* 1.24E-20*
rs2242480 CYP3A4 0.174181201 0.021891099* 0.023739907* 0.23406711 0.435345164 2.62E-23* 1.64E-15* 3.89E-36* 1.69E-28* 1.47E-36* 6.57E-33* 1.50E-30* 0.409092294 0.192100104 1.35E-07* 0.08254084 6.01E-14* 3.60E-12* 5.94E-12* 2.02E-09* 1.22E-11* 0.17415559 0.803974761 0.115551578 0.089908531 0.456718839
rs1805123 KCNH2   0.001573873*            0.000823584* 0.056854534   1.21E-05* 1.31E-06* 0.004686145* 1.77E-07* 3.87E-08* 2.29E-09* 2.02E-09* 1.52E-06* 2.17E-08* 0.00023004* 2.36E-05*
rs4646244 NAT2 0.908457449 0.610136371 0.315761804 0.54419548 0.005511981* 0.539375881 0.681282207 0.569019305 0.731729318 0.470793074 0.766246664 0.573758645 0.765141605 0.045785995* 0.001228669* 0.743776944 0.059300297 0.228557873 0.287926694 0.380483065 0.197043557 0.719514347 0.000339744* 0.016243392* 0.0063584 3.97E-05*
rs4271002 NAT2 0.066715616 0.189042432 0.327040513 0.208044975 0.299878957 0.000159278* 0.007107265* 3.30E-10* 3.72E-10* 2.07E-05* 0.000330686* 4.77E-06* 0.000635858* 0.417562363 0.072199748 0.357070744 1.74E-06* 0.001117691* 0.077554184 0.006521172* 0.060691113 0.476861068 0.006951173* 0.000332936* 0.008015007* 0.008719915*
rs1041983 NAT2 0.3 0.101689882 0.998513527 0.036626279* 0.132118736 0.629462005 0.990184178 0.158209247 0.24464648 0.844220999 0.183124559 0.610133391 0.007677766* 0.001717351* 1.66E-05* 0.001063258* 0.00091851* 0.000817232* 0.001042721* 0.010149174* 0.001176575* 0.155505108 0.951353573 0.383411457 0.677678934 0.579411379
rs1801280 NAT2      0.356035128 4.89E-14* 4.38E-14* 2.97E-14 6.83E-19 9.29E-22 4.03E-11 2.25E-11 2.47E-21 8.41E-19 6.89E-15 4.17E-22 2.27E-25 1.72E-27 3.07E-27 1.97E-30 1.73E-26 4.00E-19 1.06E-18 8.10E-20 6.31E-25 3.64E-15
rs1799929 NAT2      0.361199143 4.69E-11* 5.21E-11* 1.75E-08* 1.49E-15* 8.89E-19* 9.21E-08* 2.85E-06* 4.54E-20* 4.43E-18* 3.32E-14* 2.50E-19* 3.12E-25* 5.32E-26* 9.84E-26* 2.87E-30* 1.73E-26* 6.28E-18* 3.27E-16* 5.98E-18* 9.49E-22* 3.69E-14*
rs1799930 NAT2 0.972002065 0.618005239 0.751795155 0.694537677 0.012320182* 0.69375469 0.192800923 0.730809 0.372603522 0.412257221 0.783101212 0.584057039 0.881554266 0.05609109 0.000190302* 0.758530406 0.111309329 0.239563334 0.199562595 0.259685706 0.456150126 0.660367076 0.000563153* 0.020071798* 0.004077679* 1.56E-05*
rs1208 NAT2      0.323358729 1.18E-20* 2.46E-17* 3.46E-22* 1.32E-27* 1.45E-27* 4E-19* 2.65E-22* 6.25E-22* 4.16E-23* 6.89E-15* 5.00E-22* 6.43E-24* 1.92E-25* 8.03E-26* 1.73E-30* 4.24E-27* 9.85E-22* 1.06E-18* 9.54E-20* 1.22E-25* 2.87E-17*
rs1799931 NAT2 0.184796686 0.049117201* 0.317619594 0.00015301* 0.47411742 2.09E-08* 3.35E-05* 6.27E-11* 8.62E-12* 1.51E-11* 8.44E-07* 4.04E-09* 7.83E-06* 0.068024303 0.013692827* 2.98E-05* 3.40E-12* 1.03E-08* 1.72E-09* 1.60E-09* 3.59E-11* 0.00114834* 2.94E-07* 9.44E-07* 1.38E-06* 1.99E-05*
rs1495741 NAT2 0.050954298 3.07932E-07* 0.011465852* 5.51E-08* 0.65417351 0.507903694 0.486579857 0.257460454 0.281747884 0.696434574 0.119487491 0.019989993* 0.041821768* 0.67785097 0.070175871 0.248664031 0.043637899* 0.00729876* 0.003075161* 5.75E-05* 0.029405924* 0.055676203 0.000771028* 0.011226574* 6.30E-06* 7.45E-05*
rs2115819 ALOX5 0.002595851* 0.000362646* 0.071696502 0.008651836* 0.093741999 1.65E-37* 8.62E-25* 4.45E-37* 5.67E-41* 9.79E-33* 1.05E-31* 5.94E-40* 3.77E-16* 9.55E-11* 9.96E-07* 1.12E-14* 5.62E-24* 3.92E-19* 3.07E-18* 6.98E-20* 8.90E-21* 9.03E-16* 6.62E-23* 1.72E-20* 9.48E-16* 2.24E-14*
rs4244285 CYP2C19 0.011385106* 0.084348706 0.104324626 0.277350778 0.037979119* 8.78E-08* 2.52E-06* 6.75E-05* 3.23E-10* 0.000120419* 6.92E-06* 1.11E-07* 9.77E-11* 2.52E-07* 4.15E-14* 8.47E-10* 2.17E-09* 0.000116625* 5.20E-08* 7.41E-09* 4.51E-13* 0.357083431 0.187693423 0.922883969 0.176804078 0.86504652
rs1057910 CYP2C9    0.199109143                   0.00223127   5.21E-07* 0.000111245* 0.000272478*  
rs11572103 CYP2C8       1.57E-16* 5.93E-10* 7.08E-15* 8.71E-19* 3.56E-09* 5.00E-12* 1.60E-14*               
rs7909236 CYP2C8   0.001111119    0.284095031         6.35E-18* 1.17E-16* 1.77E-22* 1.70E-08* 1.45E-16* 3.59E-15* 1.16E-11* 3.98E-10* 2.96E-09* 1.61E-09* 3.50E-14* 3.03E-12* 1.49E-09* 3.17E-06*
rs17110453 CYP2C8 0.021440387* 0.826534465 0.858474033 0.794091714 0.043147139* 6.00E-20* 2.07E-14* 1.87E-20* 2.78E-24* 5.66E-22* 1.40E-19* 1.07E-22* 8.29E-11* 2.41E-07* 5.14E-14* 5.74E-10* 1.31E-11* 0.000358179* 6.93E-10* 0.000120667* 4.47E-11* 0.391440466 0.295282612 0.706742958 0.058493 0.76290557
rs3813867 CYP2E1 0.006552652* 3.59E-06* 0.000102114* 0.000102412* 2.78E-06 0.742811481 0.550417961 0.305302386 0.279166336 0.068293812 0.914073362 0.730517163 0.044163386* 0.009317049* 0.003053677* 0.452117467 0.47034354 0.246502725 0.104281398 0.044268805* 0.388354635 0.01515297* 0.004894979* 0.00523142* 0.007795656* 0.001761454*
rs2031920 CYP2E1 0.093771053 8.07E-05* 0.003359719* 0.004926448* 0.000300332* 5.35E-05* 0.016624442* 3.99E-05* 1.02E-05* 3.99E-05* 0.00015751* 1.66E-05* 0.253219685 0.120657802 0.09925265 0.219031776 0.272358474 0.037336905* 0.015728559* 0.004271931* 0.136905408 0.001606451* 0.000331478* 0.000363614* 0.000634024* 0.000111032*
rs6413432 CYP2E1 4.2E-19* 1.31E-16* 1.45E-15* 3.14E-16* 1.66E-19*    0.003915588* 0.000270607*   0.065854286 0.000530663* 6.57E-10* 4.59E-08* 9.02E-09* 2.97E-09* 1.63E-06* 1.26E-05* 0.015544772* 0.008287334* 9.51E-05* 8.46E-12* 1.83E-17* 7.76E-12* 9.13E-08* 2.51E-12*
rs2070676 CYP2E1 0.002553305* 0.827109248 0.672645828 0.614168132 0.448640164 3.81E-30* 1.06E-17* 1.00E-28* 5.52E-30* 2.70E-35* 3.78E-31* 7.09E-28* 0.290749722 0.022443644* 0.031891018* 0.002072634* 0.359414667 0.006774321* 0.034512086* 0.365848056 0.435369755 0.859781523 0.467538122 0.648934849 0.840697344 0.330668697
rs5219 KCNJ11 0.003978161* 0.000521662* 0.073272148 0.026139453* 0.041995705* 4.08E-16* 5.26E-07* 1.86E-24* 2.18E-25* 1.16E-23* 7.22E-22* 4.56E-26* 6.22E-05* 0.030526542* 0.289021265 0.002118976* 0.171703986 0.003250285* 0.047623834* 0.008845052* 0.005988539* 0.000383538* 0.000294121* 0.00355488* 3.67E-07* 0.023357634*
rs1801028 DRD2   0.002743098* 0.003159452*               0.032791444*       1.31E-13*    9.84E-09*
rs2306283 SLCO1B1 0.658512672 0.205950281 0.516381109 9.67E-06* 0.255712933 0.343484593 0.092030119 0.155670314 0.421337787 0.240886061 0.739594068 0.842983386 8.87E-16* 5.47E-20* 2.85E-16* 5.37E-13* 1.50E-21* 3.18E-19* 3.33E-24* 2.97E-22* 4.46E-25* 3.98E-10* 1.37E-11* 7.78E-09* 1.72E-17* 2.41E-11*
rs4516035 VDR        0.000250973*       1.88E-18* 9.22E-15* 3.10E-09* 7.20E-25* 2.88E-25* 7.28E-39* 1.17E-28* 3.93E-26* 4.93E-31* 1.74E-10* 3.70E-11* 1.81E-10* 1.72E-15* 7.16E-13*
rs762551 CYP1A2 0.1 0.300829362 0.634709813 0.103718477 0.314988006 0.124745263 0.69186992 0.000364292* 0.028368256* 1.00E-05* 0.037262669* 0.002040475* 0.209128456 0.032953675* 1.13E-05* 0.76149116 0.340413414 0.468062248 0.230946324 0.358933662 0.230526214 0.035152873* 0.000510748* 0.001980774* 0.003245356* 2.42E-05*
rs2472304 CYP1A2 0.014236939* 0.257348035 0.001901901* 1.73E-05* 0.004237979* 0.103421545        2.83E-16* 1.62E-07* 0.189014451 2.04E-24* 2.27E-36* 7.10E-29* 1.44E-34* 2.50E-33* 1.03E-26* 0.000626231* 0.011964466* 0.071150838 2.56E-06* 0.290829511
rs750155 SULT1A1 0.056990114 0.141351868 0.016733876* 0.351244062 0.298586001 0.550366807 0.321948571 0.002066135* 0.000560201* 0.465867078 0.097094955 0.096184189 0.005138686* 0.028868337* 3.18E-23* 0.026490062* 0.371180365 0.071724101 0.22160908 0.807754642 0.357468926 0.000453366* 0.003608286* 0.003408433* 0.049227902* 1.96E-07*
rs1800764 ACE 0.056726465 0.39143495 0.217109705 5.34E-05* 0.045931922* 2.61E-33* 8.82E-23* 1.09E-40* 1.94E-46* 1.05E-35* 2.63E-43* 7.78E-46* 4.25E-05* 0.389243603 0.47000884 1.34E-05* 6.39E-06* 4.04E-05* 0.000366475* 0.000414932* 8.38E-08* 0.016211851* 3.48E-05* 0.002243978* 0.011118101* 0.021050251*
rs4291 ACE 3.00E-30* 1.28E-35* 5.55E-31* 2.57E-26* 4.86E-35* 1.33E-28* 1.67E-29* 2.72E-30* 8.30E-26* 4.86E-35* 6.79E-26* 3.69E-35* 3.10E-29* 1.28E-34* 4.75E-42* 9.11E-29* 2.72E-30* 1.42E-24* 1.18E-31* 6.37E-28* 5.39E-31* 3.96E-29* 8.23E-28* 2.65E-35* 6.22E-30* 1.00E-28*
rs4267385 ACE 0.60706182 0.896137823 0.304531817 0.437096269 0.448897001 1.22E-24* 2.40E-15* 3.40E-26* 4.89E-32* 2.33E-33* 3.63E-30* 4.04E-30* 5.61E-06* 0.001132547* 0.876941984 3.09E-09* 2.69E-10* 1.64E-09* 1.40E-11* 1.79E-12* 7.04E-21* 0.070967336 0.001307242* 0.196898102 0.000954545* 0.008151391*
rs2108622 CYP4F2 0.688253222 0.353058471 0.579831407 0.049533921* 0.229799176 0.085598381 0.082954611 4.34E-05* 0.000977448* 0.144761136 0.129717659 0.000161974* 0.010322998* 0.071572406 0.162826967 0.004590455* 0.075664532 0.39622905 0.005888374* 2.04E-06* 2.69E-05* 1.82E-08* 1.99E-10* 2.68E-08* 1.38E-07* 1.96E-09*
rs3093105 CYP4F2 1.60E-55* 3.54E-51* 3.51E-54* 1.79E-58* 8.09E-59* 1.14E-36* 1.95E-29* 4.42E-32* 2.15E-40* 4.26E-37* 2.84E-35* 3.52E-34* 2.57E-43* 1.25E-41* 7.05E-55* 1.53E-43* 7.84E-44* 8.51E-49 1.60E-40* 6.40E-34* 1.29E-38* 4.65E-44* 1.27E-45* 1.55E-41* 1.48E-41* 1.25E-45*
rs8192726 CYP2A6 0.71094678 0.565911012 0.311301082 0.390661417 0.305375625 0.004591427* 0.245752554 0.104409227 0.002175155* 0.073757598 0.010662896* 0.10444763 0.000189151* 0.006056478* 0.00149952* 0.000247622* 0.001004263* 0.129515608 0.000373767* 0.000723061* 0.004379184* 0.496057104 0.602716704 0.243968045 0.892476883 0.243968045
rs1051298 SLC19A1 1.51E-07* 2.66E-09* 0.000482386* 3.97E-08* 2.44897E-06* 7.14E-08* 1.60E-06* 2.36E-06* 3.37E-11* 4.68E-09* 4.73E-07* 4.55E-07* 6.37E-09* 1.09E-15* 8.09E-15* 6.04E-09* 6.48E-11* 5.13E-09 5.50E-14* 4.51E-11* 2.71E-10* 1.94E-06* 7.95E-08* 2.61E-07* 3.27E-07* 2.79E-09*
rs1051296 SLC19A1 0.609205002 0.771425657 0.124768121 0.752914304 0.254101023 0.503862027 0.471517174 0.162301179 0.644086821 0.581333718 0.868173465 0.468804993 0.434021469 0.00179709 0.0062769 0.216005729 0.01134575 0.243843261 0.01625569 0.616464101 0.080496685 0.640656314 0.903856176 0.257373002 0.581655047 0.830821988
rs1131596 SLC19A1 0.022919018* 0.023544228* 0.400775632 0.005294873* 0.131694616 6.91E-11* 0.004236642* 0.000115013* 2.60E-16* 1.59E-12* 7.50E-11* 4.12E-10* 0.021820836* 2.88E-06* 8.07E-05* 0.01622849* 0.161041225 0.045935608* 9.78E-06* 0.000809244* 0.006656253* 0.01182718* 0.003770171* 0.002710073* 0.000670055* 0.002377152*
rs1065852 CYP2D6 4.20E-16 1.82E-13* 1.88E-17* 6.28E-22* 7.67E-12* 4.99E-42* 2.82E-38* 3.62E-50* 2.33E-48* 4.31E-58* 2.22E-39* 1.39E-48* 2.14E-38* 1.76E-37* 8.68E-51* 8.43E-41* 4.66E-30* 3.71E-42* 1.47E-31* 2.16E-39* 2.84E-35* 1.95E-31* 3.30E-41* 1.17E-38* 6.16E-47* 2.88E-42*
  1. EAS East Asian, AFR African, AMR American, EUR European, SAS South Asian, ACB African Caribbean in Barbados, ASW African Ancestry in Southwest US, ESN Esan in Nigeria, GWD Gambian in Western Divisions, The Gambia – Madinka, LWK Luhya in Webuye, Kenya, MSL Mende in Sierra Leone, CLM Colombian in Medellin, Colombia, MXL Mexican Ancestry in Los Angeles, California, PEL Peruvian in Lima, Peru, PUR Puerto Rican in Puerto Rico, CDX Chinese Dai in Xishuangbanna, China, YRI Yoruba in Ibadan, Nigeria, CHS Han Chinese South, JPT Japanese in Tokyo, Japan, KHV Kinh in Ho Chi Minh City, Vietnam, CEU Utah residents with Northern and Western European ancestry, FIN Finnish in Finland, GBR British in England and Scotland, IBS Iberian populations in Spain, TSI Toscani in Italy, BEB Bengali in Bangladesh, GIH Gujarati Indians in Houston, Texas, ITU Indian Telugu in the UK, PJL Punjabi in Lahore, Pakistan, STU Sri Lankan Tamil in the UK, CHB Han Chinese in Beijing, China
  2. p values were calculated from χ2 test
  3. Bold indicates*p < 0.05 indicates statistical significance