Genome-wide association study identifies new loci associated with noise-induced tinnitus in Chinese populations

BMC Genomic Data

Table 2 Association results for the rs2846071 and rs4149577 in the case/control populations

SNPs	Chr. (Cytoband)	Studies	Cases^a	Controls^a	ORs (95% CIs)	P values	I²	P_{heterogeneity}
rs2846071	11q13.5	Discovery stage	14/36/15	16/107/110	2.54 (1.63–3.96)	3.75 × 10⁻⁵	19.07	0.27
T/C^b		Replication stage	11/12/11	50/161/157	1.75 (1.08–2.84)	0.024
		Overall	25/48/26	66/277/267	2.14 (1.96–3.40)	4.89 × 10⁻⁶
rs4149577	12p13.31	Discovery stage	19/31/15	26/93/114	2.33 (1.56–3.46)	3.09 × 10⁻⁵	1.28	0.31
A/G^b		Replication stage	8/16/10	43/178/155	1.67 (1.00–2.78)	0.049
		Overall	27/47/25	69/271/269	2.05 (1.89–2.51)	6.88 × 10⁻⁶

Chr. chromosome, CI confidence interval, OR odds ratio, SNP single nucleotide polymorphism. ^aCounts of TT/TC/CC genotypes for rs2846071 and AA/AG/GG genotypes for rs4149577 in the case/control populations, respectively. These two SNPs were genotyped using the Illumina Infinium Asian Screening Array-24 (v1.0) in the discovery stage. The number of genotyped samples varies due to genotyping failure. ^bMinor allele/major allele. ORs and 95% CIs were calculated under the additive model by logistic regression while adjusting for the age and noise exposure time

ISSN: 2730-6844