Fig. 5
From: Transcriptome signature of miRNA-26b KO mouse model suggests novel targets
Transcriptome profiling demonstrates significant changes upon miRNA-26b deficiency. a ‘Volcano plot’ of statistical significance (P) against fold change (Fc) miRNA-26b+/+ and miRNA-26b−/− mice, demonstrating the most significantly differentially expressed genes (P cutoff 0.05, Fc cutoff ≦ − 1.5 or ≧1.5). Every gene is represented by an individual dot. Non-significant genes are visualized in black, significant but not differentially expressed genes in gray, significantly down-regulated genes in blue and significantly up-regulated genes in red. b Heatmap showing the top 30 differentially expressed genes, in which each row represents a single gene and each column an individual sample. Down-regulated genes are visualized in blue and up-regulated genes in red. c Bar chart showing the top 4 differentially expressed genes for miRNA-26b−/− mice inferred from transcriptomes as log2ReadCounts compared to control mice; Mbp P = 0.021128, Nnt P = 0.009119, Myocd P = 0.024823 and Hspb P = 0.000801 by multiple t-test; P < 0.0001 for the genes (PGENES), P = 0.0436 for miRNA-26b knock down (PKO), by two-way ANOVA with Bonferroni post-test. d Bar chart showing the top 4 differentially expressed genes for miRNA-26b−/− mice inferred from 2-ΔΔ(CT) compared to control mice. Data are given as mean ± SEM