Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease

Table 4 One gene identified by MR-mQTL analysis and achieved the nominal significance level in MR-eQTL analysis

	Exposure ^a	CHR	POSITION	Nearby Gene	Instrumental SNP ^b	POSITION	p.MR1^c
MR-mQTL	cg02349334	13	76,363,851	LMO7	rs530855	76,337,780	3.92e-07
					rs9318373	76,363,721
					rs660942	76,373,924
					kgp9606293	76,391,057
					rs9600564	76,435,635
MR-eQTL	LMO7	13	76,194,570–76,434,006	LMO7	rs9318373	76,363,721	8.27e-03

^a MR-mQTL evaluated the causal effect of CpG site on CHD risk, while MR-eQTL evaluated the causal effect of gene expression on CHD risk
^b 5 mQTL SNPs and 1 eQTL SNP was avaiable for MR-mQTL and MR-eQTL, respectively
^c MR analysis in CHD GWAS Phase 1

ISSN: 2730-6844