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Table 8 Top ten targeter TFs for both Human and Rhesus monkey (that are connected with maximum number of gene-modules and that regulate maximum number of genes from the connected gene-modules) with information of their maximum number of regulated genes as well as gene-modules, and verified information of them for inter-species analysis

From: Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

SL. No. TFs Number of connected gene-modules Number of regulated genes Name of the connected gene-modules (number of regulated genes in the modules) Disease-verified information of TFs for human Status of TFs for human Disease-verified information of TFs for rhesus Status of TFs for rhesus
1 ZNF286A 10 31 Black(1), Blue (2), Brown (3), Cyan (1), Green (6), Magenta (1), Purple (1), Red (2), Turquoise (7), Yellow (7). Identification and analysis of plasticity induced late response [64] known Hemi-parkinson’s disease [65] Known
2 E2F4 9 61 Black(3), Blue (14), Brown (13), Green (4), Magenta (1), Midnightblue(1), Pink(2) Turquoise (15), Yellow (8). Neurodegeneration disorder [32] Known SIV encephalitis [45] Known
3 ZNF771 9 46 Black(2), Blue (2), Brown (7), Cyan (1), Green (5), Lightcyan(1), Red (4), Turquoise (16), Yellow (8). - Unknown - Unknown
4 ZNF423 9 42 Black(2), Blue (2), Brown (3), Cyan (1), Green (6), Purple (1), Red (2), Turquoise (15), Yellow (7). Joubart’s Syndrome [67] Known - Unknown
5 SP1 9 41 Black(1), Blue (7), Brown (5), Green (3), Lightcyan(1), Purple (1), Red (2), Turquoise (15), Yellow (7). Disrupt in early Huntington’s disease [63] Known mediate members of brain aging proteins and enhancing the chances of Alzeimer’s Disease [66] Known
6 ZBTB20 7 42 Black(2), Blue (12), Brown (3), Green (1), Red (1), Turquoise (17), Yellow (6). Major depressive disorder [68] Known Age associated brain disease [46] Known
7 SP3 7 29 Black(2), Blue (3), Brown (3), Green (4), Red (3), Turquoise (10), Yellow (4). Neuro degeneration disease [69] Known - Unknown
8 LBX1 7 28 Black(1), Brown (5), Cyan (1), Green (5), Red (3), Turquoise (7), Yellow (6). Septo optic dysplasia [73] Known - Unknown
9 MYST3 7 24 Black(1), Blue (3), Brown (3), Green (1), Red (1), Turquoise (10), Yellow (5). - Unknown - Unknown
10 FOXM1 7 19 Black(1), Blue (5), Brown (5), Green (1), Red (1), Turquoise (4), Yellow (2). Glioma [47] Known - Unknown