Table 8 Top ten targeter TFs for both Human and Rhesus monkey (that are connected with maximum number of gene-modules and that regulate maximum number of genes from the connected gene-modules) with information of their maximum number of regulated genes as well as gene-modules, and verified information of them for inter-species analysis
SL. No. | TFs | Number of connected gene-modules | Number of regulated genes | Name of the connected gene-modules (number of regulated genes in the modules) | Disease-verified information of TFs for human | Status of TFs for human | Disease-verified information of TFs for rhesus | Status of TFs for rhesus |
|---|---|---|---|---|---|---|---|---|
1 | ZNF286A | 10 | 31 | Black(1), Blue (2), Brown (3), Cyan (1), Green (6), Magenta (1), Purple (1), Red (2), Turquoise (7), Yellow (7). | Identification and analysis of plasticity induced late response [64] | known | Hemi-parkinson’s disease [65] | Known |
2 | E2F4 | 9 | 61 | Black(3), Blue (14), Brown (13), Green (4), Magenta (1), Midnightblue(1), Pink(2) Turquoise (15), Yellow (8). | Neurodegeneration disorder [32] | Known | SIV encephalitis [45] | Known |
3 | ZNF771 | 9 | 46 | Black(2), Blue (2), Brown (7), Cyan (1), Green (5), Lightcyan(1), Red (4), Turquoise (16), Yellow (8). | - | Unknown | - | Unknown |
4 | ZNF423 | 9 | 42 | Black(2), Blue (2), Brown (3), Cyan (1), Green (6), Purple (1), Red (2), Turquoise (15), Yellow (7). | Joubart’s Syndrome [67] | Known | - | Unknown |
5 | SP1 | 9 | 41 | Black(1), Blue (7), Brown (5), Green (3), Lightcyan(1), Purple (1), Red (2), Turquoise (15), Yellow (7). | Disrupt in early Huntington’s disease [63] | Known | mediate members of brain aging proteins and enhancing the chances of Alzeimer’s Disease [66] | Known |
6 | ZBTB20 | 7 | 42 | Black(2), Blue (12), Brown (3), Green (1), Red (1), Turquoise (17), Yellow (6). | Major depressive disorder [68] | Known | Age associated brain disease [46] | Known |
7 | SP3 | 7 | 29 | Black(2), Blue (3), Brown (3), Green (4), Red (3), Turquoise (10), Yellow (4). | Neuro degeneration disease [69] | Known | - | Unknown |
8 | LBX1 | 7 | 28 | Black(1), Brown (5), Cyan (1), Green (5), Red (3), Turquoise (7), Yellow (6). | Septo optic dysplasia [73] | Known | - | Unknown |
9 | MYST3 | 7 | 24 | Black(1), Blue (3), Brown (3), Green (1), Red (1), Turquoise (10), Yellow (5). | - | Unknown | - | Unknown |
10 | FOXM1 | 7 | 19 | Black(1), Blue (5), Brown (5), Green (1), Red (1), Turquoise (4), Yellow (2). | Glioma [47] | Known | - | Unknown |