Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

Table 4 Top ten targeter miRNAs for Human (that are connected with maximum number of gene-modules and that target maximum number genes from the connected modules) with information of their maximum number of targeted genes as well as gene-modules, and verified information of them

Sl. No.	MiRNAs	Number of connected gene-modules	Number of targeted genes	Name of the connected gene-modules (number of targeted genes in the modules)	Disease and Disease-verified information of miRNAs	Status of miRNAs
1	hsa-miR-579	4	17	Blue (2), Brown (2), Green (1), Turquoise (12).	Alzheimer’s Disease [38]	Known
2	hsa-miR-495	4	14	Blue (5), Brown (2), Green (1), Turquoise (6).	HIV mediated dementia [39]	Known
3	hsa-miR-27b-3p-3p	4	10	Blue (5), Brown (1), Green (1), Turquoise (3).	Presence in high intensity for Alzheimer’s disease [74]	Known
4	hsa-miR-449b-5p-5p	4	10	Blue (1), Brown (2), Green (1), Turquoise (6).	Presence in low intensity in case of Alzheimer’s disease	Known
5	hsa-miR-34a	4	10	Blue (1), Brown (2), Green (1), Turquoise (6).	neuropsychaitric and nuerodegenrative diseases [40]	Known
6	hsa-miR-34c-5p	4	10	Blue (1), Brown (2), Green (1), Turquoise (6).	Bipolar disorder and Schizophenia [41]	Known
7	hsa-miR-449a	4	10	Blue (1), Brown (2), Green (1), Turquoise (6).	Molecular Targets for Neurodegenerative Diseases [42]	Known
8	hsa-miR-607	4	9	Blue (3), Brown (3), Green (1), Turquoise (2).	Neurodegenerative diseases [43]	Known
9	hsa-miR-27a-3p	4	9	Blue (4), Brown (1), Green (1), Turquoise (3).	Alzheimer’s Disease [75]	Known
10	hsa-miR-664-3p	4	9	Blue (2), Brown (2), Green (1), Turquoise (4).	Psychiatric and Neurodegenerative disease [44].	Known

ISSN: 2730-6844