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Table 1 Estimated variance inflation under relatedness

From: On the impact of relatedness on SNP association analysis

Study n \(\bar \lambda \) \(\bar \lambda _{10\%}\) λ λ f;m;c \(\bar {G}\) \(R^{2}_{\mathrm {t}}\)
HapMap 129 1.288 (0.074) 1.295 (0.051) 1.297 - 0.006 0.152
SFS1 129 1.284 (0.087) 1.293 (0.051) 1.294 1.295 0.007 0.153
SFS2 999 1.306 (0.050) 1.313 (0.020) 1.314 1.299 0.001 0.143
Sorbs 977 1.410 (0.135) 1.448 (0.071) 1.449 - 0.001 0.100
SFS3 999 2.006 (0.139) 2.022 (0.083) 2.021 2.002 0.002 0.044
  1. Variance inflation and related measures are compared between the data sets HapMap, SFS1 (synthetic family study 1), SFS2, Sorbs and SFS3 assuming \(R^{2}_{\mathrm {h}}=0.9\). Provided are the sample size n, average inflation \(\bar \lambda \) of all SNPs, average inflation \(\bar \lambda _{10\%}\) estimated for SNPs with minor allele frequencies > 10%, expected (theoretical) inflation λ obtained from estimated relationships, expected inflation λ f;m;c′ obtained from true relationships (synthetic family studies only), mean relatedness \(\bar {G}\) and heritability \(R^{2}_{\mathrm {t}}\)corresponding to inflation λt′=1.05. Standard deviations are given in parentheses
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