In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway

Table 2 Enrichment of Drosophila GO terms in the partial RNAi screen

GO ID	GO term	Genes	Count	Total	P-Value
GO:0006743	ubiquinone metabolic process	COQ7, COQ3/CG9249	2	2	0.013
GO:0006733	oxidoreduction coenzyme metabolic process	COQ7, COQ3/CG9249	2	2	0.013
GO:0042375	quinone cofactor metabolic process	COQ7, COQ3/CG9249	2	2	0.013
GO:0031966	mitochondrial membrane	COQ7, ND75, Tom20, CG6455	4	34	0.033
GO:0005740	mitochondrial envelope	COQ7, ND75, Tom20, CG6455	4	37	0.035
GO:0005739	mitochondrion	COQ7, Hsp68, Aats-phe, ND75, Tom20, CG6455	6	106	0.035
GO:0031975	envelope	COQ7, ND75, Tom20, CG6455	4	47	0.058
GO:0031967	organelle envelope	COQ7, ND75, Tom20, CG6455	4	47	0.058
GO:0044237	cellular metabolic process	betaTry, COQ7, dome, Hsp68, Ku70/Irbp, ND75, Aats-phe, pABp, Spn27A, Taf5, Ts, Cdk12/CG7597, COQ3/CG9249	13	569	0.064
GO:0031090	organelle membrane	COQ7, ND75, Tom20, CG6455	4	54	0.078

Analysis of Gene Ontology (GO) terms was performed on 21 candidate genes by GOstat (http://gostat.wehi.edu.au/). GO IDs with P-value <0.1, corresponding GO terms and list of genes are presented. Count, number of our candidate genes mapping to a GO term; Total, number of genes in our primary screen annotated with each GO term

ISSN: 2730-6844