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Table 4 Power of GRM and CAT tests to detect association for a P-value threshold of 1.0E-7 using a sample size of 1000 cases/1000 controls

From: Gain of power of the general regression model compared to Cochran-Armitage Trend tests: simulation study and application to bipolar disorder

   Simulated model: Additive Simulated model: Dominant Simulated model: Recessive
   Tests: Tests: Tests:
MAF OR CAT_DOM CAT_REC CAT_ADD GRM CAT_DOM CAT_REC CAT_ADD GRM CAT_DOM CAT_REC CAT_ADD GRM
0.1 1.2 0 0 0 0.00 0 0 0 0 0 0 0 0
0.1 1.4 0.03 0 0.04 0.02 0.02 0 0.02 0.01 0 0 0 0
0.1 1.6 0.36 0 0.42 0.27 0.25 0 0.21 0.16 0 0 0 0
0.1 1.8 0.85 0 0.89 0.80 0.72 0 0.66 0.60 0 0 0 0
0.1 2 0.99 0.03 1 0.99 0.96 0 0.94 0.92 0 0 0 0
0.1 2.2 1 0.14 1 1 1 0 0.99 0.99 0 0 0 0
0.1 2.4 1 0.38 1 1 1 0 1 1 0 0 0 0
0.1 2.6 1 0.67 1 1 1 0 1 1 0 0 0 0
0.1 2.8 1 0.88 1 1 1 0 1 1 0 0 0 0
0.1 3 0.99 0.96 1 1 1 0 1 1 0 0.01 0 0
0.1 3.2 0.99 0.99 1 1 1 0 1 1 0 0.02 0 0
0.2 1.2 0 0 0 0 0 0 0 0 0 0 0 0
0.2 1.4 0.17 0 0.26 0.17 0.07 0 0.04 0.04 0 0 0 0
0.2 1.6 0.81 0.10 0.91 0.84 0.54 0 0.41 0.43 0 0 0 0
0.2 1.8 0.99 0.50 1 1 0.93 0 0.85 0.88 0 0.01 0 0
0.2 2 1 0.88 1 1 1 0 0.99 0.99 0 0.05 0 0.01
0.2 2.2 1 0.99 1 1 1 0 1 1 0 0.14 0.01 0.05
0.2 2.4 1 1 1 1 1 0 1 1 0 0.33 0.02 0.15
0.2 2.6 1 1 1 1 1 0 1 1 0 0.55 0.04 0.33
0.2 2.8 1 1 1 1 1 0.01 1 1 0 0.75 0.10 0.54
0.2 3 1 1 1 1 1 0.01 1 1 0 0.89 0.18 0.74
0.2 3.2 1 1 1 1 1 0.01 1 1 0 0.96 0.29 0.88
0.3 1.2 0 0 0.01 0 0 0 0 0 0 0 0 0
0.3 1.4 0.27 0.05 0.48 0.36 0.08 0 0.04 0.05 0 0 0 0
0.3 1.6 0.90 0.52 0.98 0.96 0.55 0 0.33 0.44 0 0.03 0 0.01
0.3 1.8 1 0.94 1 1 0.93 0 0.77 0.88 0 0.18 0.02 0.10
0.3 2 1 1 1 1 1 0 0.96 0.99 0 0.51 0.08 0.36
0.3 2.2 1 1 1 1 1 0 1 1 0 0.81 0.23 0.69
0.3 2.4 1 1 1 1 1 0 1 1 0 0.96 0.46 0.91
0.3 2.6 1 1 1 1 1 0.01 1 1 0.01 0.99 0.70 0.98
0.3 2.8 1 1 1 1 1 0.01 1 1 0.02 1 0.87 1
0.3 3 1 1 1 1 1 0.02 1 1 0.04 1 0.95 1
0.3 3.2 1 1 1 1 1 0.03 1 1 0.07 1 0.99 1
0.4 1.2 0 0 0.01 0 0 0 0 0 0 0 0 0
0.4 1.4 0.26 0.16 0.58 0.47 0.05 0 0.01 0.03 0 0.01 0 0
0.4 1.6 0.88 0.80 0.99 0.98 0.40 0 0.16 0.30 0 0.17 0.03 0.10
0.4 1.8 1 0.99 1 1 0.83 0 0.49 0.74 0 0.59 0.18 0.47
0.4 2 1 1 1 1 0.98 0 0.79 0.95 0 0.91 0.50 0.85
0.4 2.2 1 1 1 1 1 0 0.94 0.99 0.01 0.99 0.80 0.98
0.4 2.4 1 1 1 1 1 0 0.99 1 0.02 1 0.95 1
0.4 2.6 1 1 1 1 1 0.01 1 1 0.05 1 0.99 1
0.4 2.8 1 1 1 1 1 0.01 1 1 0.10 1 1 1
0.4 3 1 1 1 1 1 0.01 1 1 0.18 1 1 1