Table 3 Power of GRM and CAT tests to detect association for a P-value threshold of 1.0E-5 using a sample size of 1000 cases/1000 controls
Simulated model: Additive | Simulared model: Dominant | Simulated model: Recessive | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tests : | Tests : | Tests : | |||||||||||
MAF | OR | CAT_DOM | CAT_REC | CAT_ADD | GRM | CAT_DOM | CAT_REC | CAT_ADD | GRM | CAT_DOM | CAT_REC | CAT_ADD | GRM |
0.1 | 1.2 | 0 | 0 | 0.01 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
0.1 | 1.4 | 0.17 | 0 | 0.20 | 0.11 | 0.12 | 0 | 0.11 | 0.07 | 0 | 0 | 0 | 0 |
0.1 | 1.6 | 0.71 | 0.01 | 0.77 | 0.64 | 0.59 | 0 | 0.54 | 0.47 | 0 | 0 | 0 | 0 |
0.1 | 1.8 | 0.97 | 0.06 | 0.99 | 0.96 | 0.93 | 0 | 0.91 | 0.88 | 0 | 0 | 0 | 0 |
0.1 | 2 | 1 | 0.23 | 1 | 1 | 1 | 0 | 0.99 | 0.99 | 0 | 0 | 0 | 0 |
0.1 | 2.2 | 1 | 0.51 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.01 | 0 | 0 |
0.1 | 2.4 | 1 | 0.78 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.01 | 0 | 0 |
0.1 | 2.6 | 1 | 0.93 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.03 | 0 | 0 |
0.1 | 2.8 | 1 | 0.99 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.06 | 0 | 0 |
0.1 | 3 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0 | 0.10 | 0 | 0 |
0.1 | 3.2 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0 | 0.16 | 0 | 0 |
0.2 | 1.2 | 0.02 | 0 | 0.03 | 0.01 | 0.01 | 0 | 0.01 | 0 | 0 | 0 | 0 | 0 |
0.2 | 1.4 | 0.49 | 0.05 | 0.61 | 0.48 | 0.29 | 0 | 0.22 | 0.20 | 0 | 0 | 0 | 0 |
0.2 | 1.6 | 0.96 | 0.39 | 0.99 | 0.97 | 0.85 | 0 | 0.75 | 0.76 | 0 | 0.02 | 0 | 0.01 |
0.2 | 1.8 | 1 | 0.83 | 1 | 1 | 0.99 | 0 | 0.98 | 0.98 | 0 | 0.08 | 0.01 | 0.03 |
0.2 | 2 | 1 | 0.98 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0 | 0.24 | 0.02 | 0.12 |
0.2 | 2.2 | 1 | 1 | 1 | 1 | 1 | 0.02 | 1 | 1 | 0 | 0.46 | 0.05 | 0.29 |
0.2 | 2.4 | 1 | 1 | 1 | 1 | 1 | 0.03 | 1 | 1 | 0 | 0.70 | 0.12 | 0.53 |
0.2 | 2.6 | 1 | 1 | 1 | 1 | 1 | 0.04 | 1 | 1 | 0.01 | 0.86 | 0.22 | 0.74 |
0.2 | 2.8 | 1 | 1 | 1 | 1 | 1 | 0.06 | 1 | 1 | 0.01 | 0.95 | 0.36 | 0.88 |
0.2 | 3 | 1 | 1 | 1 | 1 | 1 | 0.08 | 1 | 1 | 0.02 | 0.98 | 0.51 | 0.96 |
0.2 | 3.2 | 1 | 1 | 1 | 1 | 1 | 0.11 | 1 | 1 | 0.03 | 1 | 0.65 | 0.99 |
0.3 | 1.2 | 0.03 | 0.01 | 0.06 | 0.03 | 0.01 | 0 | 0.01 | 0.01 | 0 | 0 | 0 | 0 |
0.3 | 1.4 | 0.61 | 0.25 | 0.81 | 0.71 | 0.31 | 0 | 0.19 | 0.22 | 0 | 0.02 | 0 | 0.01 |
0.3 | 1.6 | 0.98 | 0.83 | 1 | 1 | 0.85 | 0 | 0.68 | 0.77 | 0 | 0.17 | 0.03 | 0.10 |
0.3 | 1.8 | 1 | 0.99 | 1 | 1 | 0.99 | 0.01 | 0.95 | 0.98 | 0 | 0.51 | 0.12 | 0.38 |
0.3 | 2 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0 | 0.83 | 0.32 | 0.73 |
0.3 | 2.2 | 1 | 1 | 1 | 1 | 1 | 0.03 | 1 | 1 | 0.02 | 0.97 | 0.57 | 0.93 |
0.3 | 2.4 | 1 | 1 | 1 | 1 | 1 | 0.04 | 1 | 1 | 0.03 | 1 | 0.80 | 0.99 |
0.3 | 2.6 | 1 | 1 | 1 | 1 | 1 | 0.07 | 1 | 1 | 0.07 | 1 | 0.93 | 1 |
0.3 | 2.8 | 1 | 1 | 1 | 1 | 1 | 0.09 | 1 | 1 | 0.12 | 1 | 0.98 | 1 |
0.3 | 3 | 1 | 1 | 1 | 1 | 1 | 0.12 | 1 | 1 | 0.19 | 1 | 1 | 1 |
0.3 | 3.2 | 1 | 1 | 1 | 1 | 1 | 0.15 | 1 | 1 | 0.28 | 1 | 1 | 1 |
0.4 | 1.2 | 0.03 | 0.02 | 0.08 | 0.04 | 0.01 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
0.4 | 1.4 | 0.61 | 0.47 | 0.87 | 0.80 | 0.23 | 0 | 0.10 | 0.15 | 0 | 0.09 | 0.02 | 0.05 |
0.4 | 1.6 | 0.98 | 0.96 | 1 | 1 | 0.75 | 0 | 0.46 | 0.64 | 0 | 0.48 | 0.16 | 0.36 |
0.4 | 1.8 | 1 | 1 | 1 | 1 | 0.97 | 0.01 | 0.81 | 0.94 | 0.01 | 0.88 | 0.50 | 0.80 |
0.4 | 2 | 1 | 1 | 1 | 1 | 1 | 0.01 | 0.96 | 1 | 0.03 | 0.99 | 0.82 | 0.97 |
0.4 | 2.2 | 1 | 1 | 1 | 1 | 1 | 0.02 | 0.99 | 1 | 0.06 | 1 | 0.96 | 1 |
0.4 | 2.4 | 1 | 1 | 1 | 1 | 1 | 0.03 | 1 | 1 | 0.13 | 1 | 1 | 1 |
0.4 | 2.6 | 1 | 1 | 1 | 1 | 1 | 0.05 | 1 | 1 | 0.23 | 1 | 1 | 1 |
0.4 | 2.8 | 1 | 1 | 1 | 1 | 1 | 0.07 | 1 | 1 | 0.36 | 1 | 1 | 1 |
0.4 | 3 | 1 | 1 | 1 | 1 | 1 | 0.09 | 1 | 1 | 0.50 | 1 | 1 | 1 |
0.4 | 3.2 | 1 | 1 | 1 | 1 | 1 | 0.11 | 1 | 1 | 0.64 | 1 | 1 | 1 |