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Table 3 Power of GRM and CAT tests to detect association for a P-value threshold of 1.0E-5 using a sample size of 1000 cases/1000 controls

From: Gain of power of the general regression model compared to Cochran-Armitage Trend tests: simulation study and application to bipolar disorder

  Simulated model: Additive Simulared model: Dominant Simulated model: Recessive
   Tests : Tests : Tests :
MAF OR CAT_DOM CAT_REC CAT_ADD GRM CAT_DOM CAT_REC CAT_ADD GRM CAT_DOM CAT_REC CAT_ADD GRM
0.1 1.2 0 0 0.01 0 0 0 0 0 0 0 0 0
0.1 1.4 0.17 0 0.20 0.11 0.12 0 0.11 0.07 0 0 0 0
0.1 1.6 0.71 0.01 0.77 0.64 0.59 0 0.54 0.47 0 0 0 0
0.1 1.8 0.97 0.06 0.99 0.96 0.93 0 0.91 0.88 0 0 0 0
0.1 2 1 0.23 1 1 1 0 0.99 0.99 0 0 0 0
0.1 2.2 1 0.51 1 1 1 0 1 1 0 0.01 0 0
0.1 2.4 1 0.78 1 1 1 0 1 1 0 0.01 0 0
0.1 2.6 1 0.93 1 1 1 0 1 1 0 0.03 0 0
0.1 2.8 1 0.99 1 1 1 0 1 1 0 0.06 0 0
0.1 3 1 1 1 1 1 0.01 1 1 0 0.10 0 0
0.1 3.2 1 1 1 1 1 0.01 1 1 0 0.16 0 0
0.2 1.2 0.02 0 0.03 0.01 0.01 0 0.01 0 0 0 0 0
0.2 1.4 0.49 0.05 0.61 0.48 0.29 0 0.22 0.20 0 0 0 0
0.2 1.6 0.96 0.39 0.99 0.97 0.85 0 0.75 0.76 0 0.02 0 0.01
0.2 1.8 1 0.83 1 1 0.99 0 0.98 0.98 0 0.08 0.01 0.03
0.2 2 1 0.98 1 1 1 0.01 1 1 0 0.24 0.02 0.12
0.2 2.2 1 1 1 1 1 0.02 1 1 0 0.46 0.05 0.29
0.2 2.4 1 1 1 1 1 0.03 1 1 0 0.70 0.12 0.53
0.2 2.6 1 1 1 1 1 0.04 1 1 0.01 0.86 0.22 0.74
0.2 2.8 1 1 1 1 1 0.06 1 1 0.01 0.95 0.36 0.88
0.2 3 1 1 1 1 1 0.08 1 1 0.02 0.98 0.51 0.96
0.2 3.2 1 1 1 1 1 0.11 1 1 0.03 1 0.65 0.99
0.3 1.2 0.03 0.01 0.06 0.03 0.01 0 0.01 0.01 0 0 0 0
0.3 1.4 0.61 0.25 0.81 0.71 0.31 0 0.19 0.22 0 0.02 0 0.01
0.3 1.6 0.98 0.83 1 1 0.85 0 0.68 0.77 0 0.17 0.03 0.10
0.3 1.8 1 0.99 1 1 0.99 0.01 0.95 0.98 0 0.51 0.12 0.38
0.3 2 1 1 1 1 1 0.01 1 1 0 0.83 0.32 0.73
0.3 2.2 1 1 1 1 1 0.03 1 1 0.02 0.97 0.57 0.93
0.3 2.4 1 1 1 1 1 0.04 1 1 0.03 1 0.80 0.99
0.3 2.6 1 1 1 1 1 0.07 1 1 0.07 1 0.93 1
0.3 2.8 1 1 1 1 1 0.09 1 1 0.12 1 0.98 1
0.3 3 1 1 1 1 1 0.12 1 1 0.19 1 1 1
0.3 3.2 1 1 1 1 1 0.15 1 1 0.28 1 1 1
0.4 1.2 0.03 0.02 0.08 0.04 0.01 0 0 0 0 0 0 0
0.4 1.4 0.61 0.47 0.87 0.80 0.23 0 0.10 0.15 0 0.09 0.02 0.05
0.4 1.6 0.98 0.96 1 1 0.75 0 0.46 0.64 0 0.48 0.16 0.36
0.4 1.8 1 1 1 1 0.97 0.01 0.81 0.94 0.01 0.88 0.50 0.80
0.4 2 1 1 1 1 1 0.01 0.96 1 0.03 0.99 0.82 0.97
0.4 2.2 1 1 1 1 1 0.02 0.99 1 0.06 1 0.96 1
0.4 2.4 1 1 1 1 1 0.03 1 1 0.13 1 1 1
0.4 2.6 1 1 1 1 1 0.05 1 1 0.23 1 1 1
0.4 2.8 1 1 1 1 1 0.07 1 1 0.36 1 1 1
0.4 3 1 1 1 1 1 0.09 1 1 0.50 1 1 1
0.4 3.2 1 1 1 1 1 0.11 1 1 0.64 1 1 1