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Table 6 Pooled analysis for the association between ABCB1 C3435T polymorphism and breast cancer risk

From: Association between ABCB1 C3435T polymorphism and breast cancer risk: a Moroccan case-control study and meta-analysis

Study

Dominant model

CC vs. TT + CT

Recessive model

TT vs. CC + CT

Allele contrast model

T vs. C

OR

95 % CI

P value

OR

95 % CI

P value

OR

95 % CI

P value

Tazzite et al. 2016 (current paper)

1.429

0.710 to 2.875

 

1.743

0.619 to 4.910

 

0.947

0.564 to 1.590

 

Abuhaliema et al. 2016 [26]

2.280

1.405 to 3.700

0.359

0.200 to 0.645

0.482

0.347 to 0.670

Ghafouri et al. 2016 [25]

1.255

0.728 to 2.165

2.099

0.806 to 5.466

1.000

0.636 to 1.571

Gutierrez-Rubio et al. 2015 [24]

0.847

0.555 to 1.292

0.819

0.463 to 1.447

1.027

0.767 to 1.375

Macías-Gómez et al. 2014 [23]

1.208

0.611 to 2.388

0.465

0.206 to 1.052

0.752

0.502 to 1.127

Fawzy et al. 2014 [22]

0.692

0.454 to 1.055

2.125

1.185 to 3.811

1.455

1.086 to 1.948

Rubis et al. 2012 [21]

0.877

0.559 to 1.376

1.399

0.908 to 2.157

1.200

0.914 to 1.577

Wu et al. 2012 [20]

0.903

0.763 to 1.069

1.365

1.100 to 1.693

1.145

1.021 to 1.285

Abbas et al. 2010 [19]

0.997

0.897 to 1.108

1.046

0.949 to 1.153

1.020

0.958 to 1.085

Taheri et al. 2010 [18]

0.909

0.343 to 2.411

0.996

0.414 to 2.395

1.029

0.596 to 1.774

Cizmarikova et al. 2010 [17]

0.586

0.350 to 0.980

1.613

0.946 to 2.753

1.471

1.066 to 2.030

Tatari et al. 2009 [16]

0.963

0.427 to 2.173

1.288

0.669 to 2.479

1.122

0.738 to 1.705

George et al. 2009 [15]

0.362

0.144 to 0.915

1.857

0.953 to 3.618

1.782

1.119 to 2.838

Henriquez-Hernandez et al. 2009 [14]

0.889

0.562 to 1.408

1.307

0.792 to 2.158

1.142

0.856 to 1.522

Turgut et al. 2007 [13]

0.249

0.093 to 0.663

1.936

0.773 to 4.848

2.051

1.189 to 3.541

Nordgard et al. 2007 [12]

0.580

0.245 to 1.371

0.949

0.533 to 1.688

1.105

0.738 to 1.653

Total (fixed effects)

0.952

0.882 to 1.028

0.209

1.110

1.027 to 1.200

0.008

1.059

1.010 to 1.111

0.017

Total (random effects)

0.907

0.767 to 1.073

0.250

1.181

0.973 to 1.434

0.093

1.098

0.972 to 1.240

0.133

Test for heterogeneity

Q = 35.1721

DF = 15

I2 = 57.35 %

Ph = 0.0023

Q = 39.4836

DF = 15

I2 = 62.01 %

Ph = 0.0005

Q = 48.4431

DF = 15

I2 = 69.04 %

Ph < 0.0001

  1. Values in italic are statistically significant (P value <0.05); Random effects model was used when Ph < 0.05 otherwise fixed effects model was used
  2. CC homozygous wild-type, CT heterozygous, TT homozygous mutant, OR Odd Ratio, CI Confidence Interval, Q chi-squared statistic, DF degrees of freedom; I2: percentage of total variation across studies due to heterogeneity; Ph: P value of Q test for heterogeneity test
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