|
MESA Hispanics
|
WHI Hispanics
|
SNP
|
Minor Allele
|
Chr
|
Gene
|
Bp
|
MAF
|
beta
|
95 % CI
|
pb
|
MAF
|
beta
|
95 % CI
|
pb
|
rs2081325
|
T
|
2
|
intergenic
|
118,205,061
|
0.015
|
3.987
|
(2.307, 5.667)
|
3.67 × 10−06
|
0.009
|
0.155
|
(−1.174, 1.483)
|
0.820
|
rs12253976
|
G
|
10
|
KLF6
|
3,825,732
|
0.011
|
5.792
|
(3.885, 7.698)
|
3.43 × 10−09
|
0.008
|
0.598
|
(−0.837, 2.032)
|
0.414
|
rs1409874
|
T
|
10
|
intergenic
|
6,690,432
|
0.322
|
−1.045
|
(−1.488, −0.602)
|
4.22 × 10−06
|
0.312
|
−0.089
|
(−0.380, 0.202)
|
0.550
|
rs1249269
|
G
|
10
|
intergenic
|
28,660,149
|
0.414
|
1.030
|
(0.635, 1.425)
|
3.79 × 10−07
|
0.410
|
−0.197
|
(−0.472, 0.077)
|
0.159
|
rs11007044
|
A
|
10
|
intergenic
|
28,680,671
|
0.171
|
1.290
|
(0.772, 1.808)
|
1.19 × 10−06
|
0.176
|
−0.113
|
(−0.465, 0.239)
|
0.530
|
rs12255372
|
T
|
10
|
TCF7L2
|
114,798,892
|
0.244
|
−1.111
|
(−1.578, −0.645)
|
3.33 × 10−06
|
0.249
|
−0.304
|
(−0.613, 0.006)
|
0.054
|
rs16943469
|
T
|
17
|
YPEL2
|
54,799,958
|
0.015
|
3.984
|
(2.362, 5.607)
|
1.68 × 10−06
|
0.006
|
0.229
|
(−1.475, 1.932)
|
0.793
|
rs6038725
|
A
|
20
|
intergenic
|
7,081,039
|
0.426
|
−1.038
|
(−1.429, −0.647)
|
2.24 × 10−07
|
0.384
|
0.218
|
(−0.054, 0.489)
|
0.116
|
rs179747
|
G
|
20
|
intergenic
|
7,107,995
|
0.444
|
−1.065
|
(−1.455, −0.676)
|
1.01 × 10−07
|
0.392
|
0.228
|
(−0.044, 0.501)
|
0.101
|
rs6085916
|
G
|
20
|
intergenic
|
7,112,725
|
0.451
|
−1.028
|
(−1.416, −0.641)
|
2.28 × 10−07
|
0.399
|
0.197
|
(−0.078, 0.472)
|
0.160
|
rs2326897
|
C
|
20
|
intergenic
|
7,112,922
|
0.449
|
−1.051
|
(−1.439, −0.662)
|
1.39 × 10−07
|
0.397
|
0.197
|
(−0.073, 0.467)
|
0.153
|
rs13036410
|
T
|
20
|
intergenic
|
7,122,578
|
0.445
|
−1.047
|
(−1.433, −0.661)
|
1.29 × 10−07
|
0.391
|
0.219
|
(−0.050, 0.488)
|
0.111
|
| | | | |
MESA African Americans
|
WHI African Americans
|
SNP
|
Minor Allele
|
Chr
|
Gene
|
Bp
|
MAF
|
beta
|
95 % CI
|
pb
|
MAF
|
beta
|
95 % CI
|
pb
|
rs7602754
|
C
|
2
|
intergenic
|
19,315,168
|
0.356
|
−0.956
|
(−1.362, −0.549)
|
4.41 × 10−06
|
0.340
|
0.099
|
(−0.117, 0.315)
|
0.370
|
rs6435678
|
C
|
2
|
ERBB4
|
212,418,713
|
0.231
|
1.104
|
(0.643, 1.564)
|
2.85 × 10−06
|
0.235
|
0.232
|
(−0.009, 0.476)
|
0.061
|
rs6739663
|
A
|
2
|
intergenic
|
240,878,904
|
0.499
|
−0.926
|
(−1.319, −0.532)
|
4.45 × 10−06
|
0.494
|
−0.194
|
(−0.399, 0.008)
|
0.062
|
rs7763896
|
C
|
6
|
CTGF
|
132,321,497
|
0.026
|
3.140
|
(1.927, 4.352)
|
4.35 × 10−07
|
0.026
|
−0.175
|
(−0.806, 0.460)
|
0.589
|
rs1567101
|
A
|
10
|
intergenic
|
30,901,089
|
0.386
|
1.030
|
(0.627, 1.433)
|
5.96 × 10−07
|
0.392
|
0.033
|
(−0.178, 0.242)
|
0.761
|
rs7092615
|
T
|
10
|
intergenic
|
30,902,186
|
0.375
|
1.025
|
(0.619, 1.431)
|
8.36 × 10−07
|
0.386
|
0.061
|
(−0.149, 0.271)
|
0.567
|
rs12826956
|
G
|
12
|
intergenic
|
73,122,021
|
0.150
|
1.300
|
(0.753, 1.847)
|
3.48 × 10−06
|
0.152
|
0.010
|
(−0.277, 0.292)
|
0.945
|
rs2822787
|
A
|
21
|
SAMSN1
|
14,876,531
|
0.215
|
1.153
|
(0.670, 1.636)
|
3.12 × 10−06
|
0.202
|
−0.067
|
(−0.318, 0.186)
|
0.601
|
-
Abbreviations: Chr Chromosome, Bp base pair, CI confidence interval, MAF minor allele frequency
-
a Bolded SNPs have beta in the same direction and suggestive p-values in MESA and WHI
-
b p-values adjusted for all ethnic-specific linear regression model covariates; only the MESA analyses are sex-adjusted