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Table 3 Top Hispanic and African American SNPs (p < 5 × 10−6) across MESA and WHI a

From: Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans

  MESA Hispanics WHI Hispanics
SNP Minor Allele Chr Gene Bp MAF beta 95 % CI pb MAF beta 95 % CI pb
 rs2081325 T 2 intergenic 118,205,061 0.015 3.987 (2.307, 5.667) 3.67 × 10−06 0.009 0.155 (−1.174, 1.483) 0.820
 rs12253976 G 10 KLF6 3,825,732 0.011 5.792 (3.885, 7.698) 3.43 × 10−09 0.008 0.598 (−0.837, 2.032) 0.414
 rs1409874 T 10 intergenic 6,690,432 0.322 −1.045 (−1.488, −0.602) 4.22 × 10−06 0.312 −0.089 (−0.380, 0.202) 0.550
 rs1249269 G 10 intergenic 28,660,149 0.414 1.030 (0.635, 1.425) 3.79 × 10−07 0.410 −0.197 (−0.472, 0.077) 0.159
 rs11007044 A 10 intergenic 28,680,671 0.171 1.290 (0.772, 1.808) 1.19 × 10−06 0.176 −0.113 (−0.465, 0.239) 0.530
rs12255372 T 10 TCF7L2 114,798,892 0.244 −1.111 (−1.578, −0.645) 3.33 × 10−06 0.249 −0.304 (−0.613, 0.006) 0.054
 rs16943469 T 17 YPEL2 54,799,958 0.015 3.984 (2.362, 5.607) 1.68 × 10−06 0.006 0.229 (−1.475, 1.932) 0.793
 rs6038725 A 20 intergenic 7,081,039 0.426 −1.038 (−1.429, −0.647) 2.24 × 10−07 0.384 0.218 (−0.054, 0.489) 0.116
 rs179747 G 20 intergenic 7,107,995 0.444 −1.065 (−1.455, −0.676) 1.01 × 10−07 0.392 0.228 (−0.044, 0.501) 0.101
 rs6085916 G 20 intergenic 7,112,725 0.451 −1.028 (−1.416, −0.641) 2.28 × 10−07 0.399 0.197 (−0.078, 0.472) 0.160
 rs2326897 C 20 intergenic 7,112,922 0.449 −1.051 (−1.439, −0.662) 1.39 × 10−07 0.397 0.197 (−0.073, 0.467) 0.153
 rs13036410 T 20 intergenic 7,122,578 0.445 −1.047 (−1.433, −0.661) 1.29 × 10−07 0.391 0.219 (−0.050, 0.488) 0.111
      MESA African Americans WHI African Americans
SNP Minor Allele Chr Gene Bp MAF beta 95 % CI pb MAF beta 95 % CI pb
 rs7602754 C 2 intergenic 19,315,168 0.356 −0.956 (−1.362, −0.549) 4.41 × 10−06 0.340 0.099 (−0.117, 0.315) 0.370
rs6435678 C 2 ERBB4 212,418,713 0.231 1.104 (0.643, 1.564) 2.85 × 10−06 0.235 0.232 (−0.009, 0.476) 0.061
rs6739663 A 2 intergenic 240,878,904 0.499 −0.926 (−1.319, −0.532) 4.45 × 10−06 0.494 −0.194 (−0.399, 0.008) 0.062
 rs7763896 C 6 CTGF 132,321,497 0.026 3.140 (1.927, 4.352) 4.35 × 10−07 0.026 −0.175 (−0.806, 0.460) 0.589
 rs1567101 A 10 intergenic 30,901,089 0.386 1.030 (0.627, 1.433) 5.96 × 10−07 0.392 0.033 (−0.178, 0.242) 0.761
 rs7092615 T 10 intergenic 30,902,186 0.375 1.025 (0.619, 1.431) 8.36 × 10−07 0.386 0.061 (−0.149, 0.271) 0.567
 rs12826956 G 12 intergenic 73,122,021 0.150 1.300 (0.753, 1.847) 3.48 × 10−06 0.152 0.010 (−0.277, 0.292) 0.945
 rs2822787 A 21 SAMSN1 14,876,531 0.215 1.153 (0.670, 1.636) 3.12 × 10−06 0.202 −0.067 (−0.318, 0.186) 0.601
  1. Abbreviations: Chr Chromosome, Bp base pair, CI confidence interval, MAF minor allele frequency
  2. a Bolded SNPs have beta in the same direction and suggestive p-values in MESA and WHI
  3. b p-values adjusted for all ethnic-specific linear regression model covariates; only the MESA analyses are sex-adjusted