Fig. 2

Regulatory conserved region of mouse Tst gene – Tst core promoter and exon 1. Black arrow above exon 1 presents transcription start site (TSS). a Grey box presents promoter region of Tst gene. b Grey boxes show constrained elements between 39 eutherian mammals. c Lines presenting conserved polymorphism. d DNase I binding presented as grey box with its peaks as inverted triangles. e Thick grey lines showing predictions of TF binding sites. Red lines present binding site for SP1, yellow lines present binding site for NF1 and blue lines present binding site for C/EBPα transcription factor. Grey stripes present ENCODE data with peaks (inverted triangle) for TFBS (e), histone modification (f) and RNA polymerase binding (g). h The degree of DNA methylation is presented as height line (100 % (highest line) – 0 % (lowest line) methylation). i Two CpG island stripes cover the predicted CpG islands from various prediction tools. j Thick grey lines display predicted miRNA target sites within Tst exon 1. Zfx – Zinc finger protein X-linked; E2F1 – E2F transcription factor 1; Klf4 – Kruppel-like factor 4 (gut); H3K4me3 – Histone 3 lysine 4 trimethylation; H3K4me2 – Histone 3 lysine 4 dimethylation; H3K36me3 – Histone 3 lysine 36 trimethylation