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Fig. 1 | BMC Genetics

Fig. 1

From: Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia

Fig. 1

Overview of Study Design. A discovery imputation GWAS among 1616 cases and 4683 controls was followed by validation and replication genotyping in 878 cases and 2017 controls. One novel locus was identified on Chromosome 6p21. Classical HLA alleles were imputed using genotyped SNPs among the GWAS cases and controls and were tested for association with fIIP. Lung tissue gene expression was compared between a subset of GWAS cases and non-GWAS controls and across genotypes for the most significant 6p21 SNP, rs7887. Gene expression was also compared across genotypes of the most significant HLA alleles (DQB1*06:02, DRB1*15:01) within the cases with lung tissue expression data

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ISSN: 2730-6844

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