Table 1 Mutations identified in the Indigenous population and shared with the Sigma and 1000 Genome Projects. * Frequencies sorted by cases: controls; cases are defined as patients with type 2 diabetes
From: Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico
1000 Genomes Project | Sigma Project | Indigenous people | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAF | Genotypes | MAF | Genotypesa | Variant Exonic/Intronic | Gene | Gene coordenate | dbSNP138 | Chr | Start | End | Ref | Obs |
0.1984 | 2007(G/G)/451(G/T)/46(T/T) | Â | Â | Intronic 6 | Gene | 191193 | rs56913138 | Chr10 | 114901201 | 114901201 | G | T |
0.000399 | 2503(G/G)/1(G/T)/0(T/T) | Â | Â | Intronic 6 | Gene | 193976 | rs188695269 | Chr10 | 114903984 | 114903984 | G | A |
0.992412 | 19(T/T)/303(T/C)/2182(C/C) | Â | Â | Intronic 9 | Gene | 201071 | rs176632 | Chr10 | 114911079 | 114911079 | T | C |
0.002396 | 2498(C/C)/6(C/G)/0(G/G) | Â | Â | Intronic 9 | Gene | 209587 | Â | Chr10 | 114919595 | 114919595 | C | T |
0.129793 | 2179(C/C)/301(C/A)/24(A/A) | 0.0896552 | C/C = 1564:1618 C/A = 331:320 A/A = 10:16 | Exonic 15 | Gene | 215361 | rs77961654 | Chr10 | 114925369 | 114925369 | C | A |
|  |  | 0.000985222 | C/C = 1901:1950 C/G = 4:4 | Exonic 15 | Gene | 215363 | rs61724286 | Chr10 | 114925371 | 114925371 | C | G |