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Table 5 Top 20 diseases and functions discovered by IPA core analyses of focus genes reported to be associated with cancer pain in the literaturea

From: MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients

Categories Function annotation p Value
Lipid metabolism, small molecule biochemistry Synthesis of prostaglandin 1.50E-24
Inflammatory disease Chronic inflammatory disorder 3.74E-24
Drug metabolism, lipid metabolism, small molecule biochemistry Synthesis of prostaglandin E2 4.34E-24
Lipid metabolism, molecular transport, small molecule biochemistry Concentration of eicosanoid 2.19E-21
Gastrointestinal disease, inflammatory disease Inflammatory bowel disease 1.03E-20
Lipid metabolism, molecular transport, small molecule biochemistry Concentration of lipid 4.13E-20
Lipid metabolism, small molecule biochemistry Fatty acid metabolism 6.51E-20
Lipid metabolism, small molecule biochemistry Synthesis of lipid 1.01E-19
Gastrointestinal disease, inflammatory disease, inflammatory response Ulcerative colitis 1.74E-19
Connective tissue disorders, immunological disease, inflammatory disease, skeletal and muscular disorders Rheumatoid arthritis 1.84E-19
Connective tissue, inflammatory disease, skeletal and muscular disorders Rheumatic disease 4.11E-19
Connective tissue disorders, inflammatory disease, skeletal and muscular disorders Arthritis 7.15E-19
Inflammatory response Inflammation of organ 1.19E-18
Immunological disease Systemic autoimmune syndrome 1.57E-18
Infectious disease Sepsis 3.20E-18
Inflammatory response Inflammation of body region 4.40E-17
Lipid metabolism, molecular transport, small molecule biochemistry Concentration of prostaglandin 4.51E-16
Infectious disease Dengue hemorrhagic fever 6.48E-16
Inflammatory disease, organismal injury and abnormalities, respiratory disease Acute respiratory distress syndrome 1.53E-15
Cell-to-cell signaling and interaction, hematological system development and function, immune cell trafficking, inflammatory response Activation of dendritic cells 2.59E-15
  1. aRanked by p values
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