Fig. 2
From: Sex-specific genetic determinants for arterial stiffness in Dahl salt-sensitive hypertensive rats
QTLs for arterial stiffness (AS) in F2 (Dahl S x R)-intercross rats. Chromosomes with interacting QTLs in male (a, b) and female (c, d) F2 cohorts and a chromosome with a highly significant QTL detected in the combined female + male F2 cohorts were analyzed by interval mapping with bootstrap resampling method to estimate a confidence interval (QTXb19 Map Manager): Panel a, chromosome 4 (AS-m1); b, chromosome 16 (AS-m2); c, chromosome 9 (AS-f1); d, chromosome 11 (AS-f2) and e, chromosome 3 (AS-1). Yellow histograms represent the bootstrap-based confidence intervals for the detected QTLs. For a histogram with single peak, widths define the confidence interval for the QTL. Orientation of chromosomes: left → right starting from lowest Mbp. Horizontal green line for a-d mark LOD value for significant linkage (LOD ≥ 3.0). Horizontal green lines for panel e from top to bottom: highly significant LOD ≥ 4.3; significant LOD ≥ 3.0. Regression coefficient for additive effect (red lines); regression coefficient for dominance effect (blue lines); LOD (black lines)