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Table 4 Meta-analysis results1 across ethnicities in MESA2 (p-values < 1×10−5) for each depressive symptom score modeling approach

From: Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis

Approach CHR SNP Location Coded allele Coded allele frequency Z-score P-value Direction3 Closest gene4 within ±50kB
Baseline
  8 rs2440212 97270629 A 0.66 4.47 7.73×10−6 ++++ (GDF6)
  9 rs13440434 131953827 A 0.87 −4.50 6.79×10−6 ---- (GPR107)
  10 rs7087469 54339854 A 0.13 4.76 1.93×10−6 ++?+ -
  13 rs9560521 89457392 A 0.13 4.69 2.69×10−6 ++++ (LINC00559)
  16 rs8046816 71863525 A 0.47 4.53 5.92×10−6 ++++ -
  20 rs17215529 3923402 A 0.85 4.79 1.66×10−6 ++?+ RNF24
Averaged
  1 rs3100865 2795967 T 0.49 4.44 9.02×10−6 ++++ -
  2 rs41379347 191577187 T 0.89 −4.58 4.57×10−6 ??-- STAT1
  2 rs7602149 114357038 T 0.84 −4.57 4.78×10−6 --?- LOC728055
  2 rs13001068 182706602 A 0.92 4.50 6.95×10−6 ? + ?+ (PDE1A)
  7 rs697521 16730681 T 0.13 −4.74 2.12×10−6 --?- BZW2
  8 rs7350109 60753909 A 0.81 −4.5 6.88×10−6 --?- -
  11 rs1448128 121291660 C 0.24 −4.58 4.61×10−6 ---- -
  22 rs5760767 23696411 T 0.51 4.58 4.62×10−6 ++++ (TMEM211)
Repeated measures
  1 rs11590206 145665933 A 0.16 −4.72 2.33×10−6 ---- (GJA5)
  2 rs41379347 191577187 T 0.89 −5.22 1.81×10−7 ??-- STAT1
  2 rs7602149 114357038 T 0.84 −4.62 3.83×10−6 --?- LOC728055
  4 rs13139186 96637940 T 0.90 −4.48 7.44×10−6 ---- UNC5C
  4 rs233976 104823918 A 0.21 4.47 7.75×10−6 ?+++ TACR3
  7 rs11771332 86539742 A 0.81 −4.48 7.45×10−6 ?-?- (KIAA1324L)
  9 rs2211185 1332721 T 0.77 4.55 5.42×10−6 ++++ -
  18 rs2728505 21474070 A 0.55 −4.47 7.84×10−6 ---- -
  22 rs5760767 23696411 T 0.51 4.54 5.68×10−6 ++++ (TMEM211)
  1. 1filtered at ethnicity-specific minor allele frequency 5 %, where the SNP was present in at least two ethnicities, linkage disequilibrium R2 < 80 %, and heterogeneity p-value ≥ 0.1; 2Multi-Ethnic Study of Atherosclerosis; 3Order corresponding to direction positions: African, European, Chinese, Hispanic American; 4parentheses indicate location outside of gene