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Table 5 Summary of evidence for and against a role of hepcidin and the iron parameters in atherosclerosis resulting from this study

From: Iron and hepcidin as risk factors in atherosclerosis: what do the genes say?

Trait Evidence for causal role Evidence against causal role
Hepcidin Weak genomic correlations with ABI at rest and ABI after exercise - No nominally significant associations with all NIMA-related SNPs
- Genomic correlations with presence of plaque and IMT ~0
Ferritin - Directionally consistent associations of the multi-SNP score with NIMA in women - No directionally consistent associations of the multi-SNP score with NIMA in men
- Directionally consistent associations of rs651007 with NIMA -No directionally consistent associations of other variants than rs651007 (notably rs411988) with NIMA
- Weak genomic correlations with ABI at rest and ABI after exercise
- No nominally significant associations with all NIMA-related SNPs
- Genomic correlations with presence of plaque and IMT ~0
Hepcidin/ferritin Nominally significant associations with two NIMA-related SNPs - No nominally significant associations with four NIMA-related SNPs
- Genomic correlations with all NIMA ~0
Hepcidin/TS   - No nominally significant associations with all NIMA-related SNPs
- Genomic correlations with all NIMA ~0
Iron - Directionally consistent associations of the multi-SNP score with NIMA in women - No directionally consistent associations of the multi-SNP score with NIMA in men
- No directionally consistent associations of iron-related SNPs with NIMA
- No nominally significant associations with all NIMA-related SNPs
- Genomic correlations with all NIMA ~0
TIBC - Directionally consistent associations of the multi-SNP score with NIMA in women - No directionally consistent associations of the multi-SNP score with NIMA in men
- No directionally consistent associations of iron-related SNPs with NIMA
- No nominally significant associations with all NIMA-related SNPs
- Genomic correlations with all NIMA ~0
TS - Directionally consistent associations of the multi-SNP score with NIMA in women - No directionally consistent associations of the multi-SNP score with NIMA in men
- No directionally consistent associations of iron-related SNPs with NIMA
- No nominally significant associations with all NIMA-related SNPs
- Genomic correlations with all NIMA ~0
  1. ABI indicates ankle-brachial index, IMT intima media thickness, NIMA non-invasive measurement of atherosclerosis, SNP single nucleotide polymorphism, TIBC total iron-binding capacity, and TS transferrin saturation