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Table 9 Power and family-wise error rate (FWER) of FORCE, MBMDR, Plink Epistasis and Plink FastEpistasis on 6 epistasis models with or without noise

From: Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

     Model 1 Model 2 Model 3 Model 4 Model 5 Model 6
No noise FORCE Powera 1 0.97 0.96 1 0.93 0.99
FWERb 0.05 0.02 0.02 0.06 0.05 0.04
MBMDR Power 1 1 1 0.98 0.87 0.97
FWER 0.02 0 0 0.01 0.01 0.01
Plink Epistasis Power 0 1 0.32 0.98 0.9 0.97
FWER 0.04 0.05 0.02 0.02 0 0.03
FastEpistasis Power 0 1 0.38 0.98 0.81 0.84
FWER 0.07 0.07 0.02 0.02 0.01 0.05
GE FORCE Power 0.99 0.99 0.97 1 0.95 0.99
FWER 0.03 0.03 0.08 0.03 0.03 0.04
MBMDR Power 1 1 1 0.99 0.85 1
FWER 0 0 0.01 0.02 0 0
Plink Epistasis Power 0 1 0.28 0.99 0.87 0.99
FWER 0 0 0.07 0.02 0 0
FastEpistasis Power 0.01 1 0.31 1 0.74 0.92
FWER 0.04 0 0.09 0.05 0 0
MS FORCE Power 0.99 0.96 0.95 1 0.93 0.99
FWER 0.07 0.02 0.02 0.03 0.03 0.06
MBMDR Power 1 1 1 0.99 0.8 0.94
FWER 0 0 0 0 0 0
Plink Epistasis Power 0 1 0.26 1 0.8 0.97
FWER 0.03 0.02 0.08 0.02 0 0
FastEpistasis Power 0 1 0.29 1 0.67 0.91
FWER 0.06 0.01 0.1 0.04 0 0
PC FORCE Power 0.08 0.55 0.13 0.33 0.23 0.37
FWER 0.03 0.05 0.05 0.06 0.04 0.07
MBMDR Power 0.72 0.98 0.12 0.09 0.11 0.16
FWER 0 0 0 0 0 0
Plink Epistasis Power 0 0.95 0.01 0.21 0.19 0.28
FWER 0.04 0.03 0.05 0.06 0.01 0
FastEpistasis Power 0 0.99 0.01 0.23 0.07 0.21
FWER 0.07 0.03 0.04 0.06 0.01 0.01
  1. Genotype errors (GE), missing data (MS) or phenocopy (PC). aIn bold, power higher than 50%. bIn bold, FWER lower than 5%.