F4 ETEC binding on GSLs and the 12 investigated genes of the cerebroside-sulfatid pathway. The carbohydrate moiety of GSLs has been shown to bind F4 ETEC and their fimbriae. According to Coddens et al. , galactosylceramide Galβ1Cer binds to F4ab/ac ETEC and fimbriae. Twelve genes involved in the carbohydrate moiety assembly of glycosphingolipids were selected from the cerebroside-sulfatid region of the sphingolipid metabolism pathway (adapted from KEGG pathway 00600). The solid lines represent molecular interaction or relation, the dashed lines represent linked to another map (see http://www.genome.jp/kegg-bin/show_pathway%3Fmap00600 for further details).