Analysis of heterogeneity and epistasis in physiological mixed populations by combined structural equation modelling and latent class analysis

Table 8 Detected interactions in genders before and after SEM -LCA.

	Significance level
	0.0017		2.5 E-9
1 Detected in both gender and LCA	245	56.3%	196	45.1%
2 Not detected in either gender or LCA	61	14.0%	68	15.6%
3 Detected in both LCA but not in any gender	97	22.3%	133	30.6%
4 Detected only in gender	2	0.5%	2	0.5%
5 Detected in one LCA and in gender	23	5.3%	23	5.3%
6 Detected in one LCA but not in gender	7	1.6%	13	3.0%
Full agreement between both gender and LCA (1+2)	306	70.3%	264	60.7%
Detected in one or both LCA but not in gender (3+6)	104	23.9%	146	33.6%
Actual number of possible interactions	378
SNPs with no interactions (equivalent for both scenarios): TCF1		HNF4α-6

Number of interactions between the 30 SNPs included in this study at two Bonferoni corrected significance levels corresponding to a 30 SNP study (0.0017) and to a future 20-million-SNP scenario (2.5 E-9). Percentage indicates the fraction of possible number of interactions for 30 SNPs (i.e., 435)

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