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Table 3 Shift of residues with change of class according to R groups, conservation across species and PolyPhen predictions.

From: Single nucleotide polymorphisms (SNPs) in coding regions of canine dopamine- and serotonin-related genes

Gene Protein residue* Aa position Change in class according to R group Residue conservation across 5 species PolyPhen prediction§
DRD1 Thr [T]/Met [M] 354 No change Invariant Possibly damaging
DRD3 Gln [Q]/Arg [R] 294 Polar, uncharged/positively charged Variable Benign
  Leu [L]/Phe [F] 341 Nonpolar, aliphatic/aromatic Invariant Benign
DBH Lys [K]/Asn [N] 263 Positively charged/polar, uncharged Variable Benign
HTR1A Lys [K]/Gln [Q] 270 Positively charged/polar, uncharged Variable Benign
HTR1B Ile [I]/Leu [L] 53 No change Variable Benign
HTR1D Ala [A]/Val [V] 97 No change Invariant Benign
  Glu [E]/Gly [G] 263 Negatively charged/Nonpolar, aliphatic Variable Benign
HTR2B Thr [T]/Ile [I] 88 Polar, uncharged/nonpolar, aliphatic Invariant Probably damaging
  Ala [A]/Val [V] 431 No change Variable Predicted to be unknown
HTR3A Thr [T]/Met [M] 64 No change Variable Possibly damaging
  1. * Changes according to Table 2, shift in residues as result of different alleles of SNPs.
  2. † Changes according to shift of residues in column 2, respectively. Classes according to R groups as described by [37].
  3. ‡ Residue variation across five mammalian species.
  4. § Prediction of a possible damaging effect of the amino acid substitutions caused by the nsSNPs, performed with PolyPhen [4].