Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

Table 2 Nucleotide polymorphism and divergence at SRPX2

	Sequence length (nt)	π (%)	θ (%)	Divergence D (%)	θ/D	HKA probability
β-globin initiation at 11p15 [67]	6076	0.129	0.107	1.284	0.083	0.696
Noncoding region at 22q11 [68]	9901	0.088	0.139	1.353	0.103	0.605
Dystrophin intron-dys44 at Xp21 [69]	7475	0.135	0.102	0.604	0.169	0.499
PDHA1 introns at Xp22 [70]	3530	0.225	0.211	0.992	0.213	0.168
Noncoding region at Xq13.3 [71]	10200	0.045	0.083	0.922	0.090	0.655
SRPX2 introns at Xq22 (this study)	9908	0.048 (0.036)	0.062 (0.047)	0.750	0.084

nt: nucleotide; π: nucleotide diversity per site; for X chromosome data, π is corrected by multiplication by 4/3 and the uncorrected value is in brackets. θ: Watterson's estimate of polymorphism per site; for X chromosome data, θ is corrected by multiplication by 4/3 and the uncorrected value is in brackets. D: number of nucleotide differences per site between human and chimpanzee sequences. HKA probability: probability from the HKA test, with comparison to the SRPX2 intron data.

ISSN: 2730-6844