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Table 4 The effect of medication correction on heritability of lipids: the HyperGEN study

From: An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study

Phenotype Excluding medicated subjects Including medicated subjects
  N Heritability SE N Unadjusted with medications Adjusted with medications Significance
      Heritability SE Heritability SE  
African          
Americans          
   TC 2088 0.57 0.07 2184 0.49 0.06 0.59 0.06 *
   HDL-C 2080 0.30 0.05 2177 0.28 0.05 0.29 0.05  
   LDL-C 2067 0.65 0.07 2162 0.55 0.06 0.69 0.07 *
   TG 2088 0.50 0.05 2183 0.48 0.06 0.50 0.05  
Whites          
   TC 2092 0.52 0.06 2391 0.36 0.04 0.51 0.05 *
   HDL-C 2086 0.47 0.06 2385 0.50 0.05 0.48 0.05  
   LDL-C 2034 0.53 0.06 2319 0.37 0.04 0.47 0.05 *
   TG 2104 0.44 0.06 2390 0.32 0.04 0.34 0.04  
  1. * The estimates of heritability are significantly different with and without medication adjustment.
  2. BMI = Body Mass Index; TC = Total Cholesterol; HDL-C = High Density Lipoprotein Cholesterol; LDL-C = Low Density Lipoprotein Cholesterol; TG = Triglycerides.