An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study

Table 4 The effect of medication correction on heritability of lipids: the HyperGEN study

Phenotype	Excluding medicated subjects			Including medicated subjects
	N	Heritability	SE	N	Unadjusted with medications		Adjusted with medications		Significance
					Heritability	SE	Heritability	SE
African
Americans
TC	2088	0.57	0.07	2184	0.49	0.06	0.59	0.06	*
HDL-C	2080	0.30	0.05	2177	0.28	0.05	0.29	0.05
LDL-C	2067	0.65	0.07	2162	0.55	0.06	0.69	0.07	*
TG	2088	0.50	0.05	2183	0.48	0.06	0.50	0.05
Whites
TC	2092	0.52	0.06	2391	0.36	0.04	0.51	0.05	*
HDL-C	2086	0.47	0.06	2385	0.50	0.05	0.48	0.05
LDL-C	2034	0.53	0.06	2319	0.37	0.04	0.47	0.05	*
TG	2104	0.44	0.06	2390	0.32	0.04	0.34	0.04

* The estimates of heritability are significantly different with and without medication adjustment.
BMI = Body Mass Index; TC = Total Cholesterol; HDL-C = High Density Lipoprotein Cholesterol; LDL-C = Low Density Lipoprotein Cholesterol; TG = Triglycerides.

ISSN: 2730-6844