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Table 1 Mechanisms of action for the major groups of antihyperlipidemic medications and their frequency of use by the subjects in HyperGEN

From: An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study

Medication group Mechanism Frequency of use
   African Americans Caucasians
Bile sequestrants A partial removal of bile acids from the enterohepatic circulation by preventing their absorption 1 12
Fibric acid derivatives Increasing fatty acid oxidation to decrease formation of VLDL (very low density lipoprotein) triglycerides 2 39
HMG CoA reductase inhibitors Inhibiting HMG CoA reductase, the rate-limiting step in cholesterol biosynthesis 101 264
Nicotinic acid derivatives Inhibiting lipoprotein synthesis and decrease the production of VLDL particles 1 0