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Table 1 Relative power of heterogeneity tests, logistic regression, UNPHASED analyses and ANN analysis to detect association at p < 0.01 in a case control study using different disease models

From: Comparison of artificial neural network analysis with other multimarker methods for detecting genetic association

Chromosome Penetrance values Power of heterogeneity test of haplotype frequencies Power of heterogeneity test using permutation testing Power of logistic regression analysis Power of UNPHASED analysis using haplotype effects Power of UNPHASED analysis using allele effects Power of ANN analysis
7 0.01, 0.02, 0.02 0.48 0.50 0.50 0.54 0.48 0.52
7 0.01, 0.03, 0.03 0.58 0.60 0.61 0.60 0.59 0.68
17 0.01, 0.02, 0.02 0.29 0.30 0.31 0.31 0.29 0.34
17 0.01, 0.03, 0.03 0.36 0.37 0.36 0.37 0.36 0.44
7 0.01, 0.01, 0.02 0.37 0.43 0.38 0.42 0.40 0.46
7 0.01, 0.01, 0.03 0.48 0.48 0.48 0.52 0.51 0.60
17 0.01, 0.01, 0.02 0.31 0.33 0.34 0.37 0.35 0.34
17 0.01, 0.01, 0.03 0.54 0.54 0.57 0.58 0.58 0.58
All combined   0.42 0.44 0.44 0.45 0.44 0.48